Nuclear overexpression of p53 protein in transitional cell bladder carcinoma: A marker for disease progression

Journal of the National Cancer Institute

Volumn 85, Issue 1, 1993, Pages 53-59

  Sarkis, Alvaro S ^a   Dalbagni, Guido ^a   Cordon cardo, Carlos ^a   Zhang, Zuo Feng ^a   Sheinfeld, Joel ^a   Fair, William R ^a   Herr, Harry W ^a   Reuter, Victor E ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; TUMOR MARKER;

ADULT; AGED; ARTICLE; BLADDER CARCINOMA; CANCER DIAGNOSIS; CANCER GROWTH; CANCER SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; STAINING; TRANSITIONAL CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; BLADDER NEOPLASMS; CARCINOMA IN SITU; CARCINOMA, TRANSITIONAL CELL; FEMALE; GENES, P53; HUMAN; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGE; MULTIVARIATE ANALYSIS; MUTATION; NEOPLASM PROTEINS; NEOPLASM STAGING; NEOVASCULARIZATION, PATHOLOGIC; PROGNOSIS; PROTEIN P53; RETROSPECTIVE STUDIES; SUPPORT, U.S. GOV'T, P.H.S.; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 0027411102     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/85.1.53     Document Type: Article

References (23)

1. Williams JL, Hammonds JC, Saunders N; T1 bladder tumours. Br J Urol 49:663-668, 1977
2. Anderstrom C, Johansson S, Nilsson S: The significance of lamina propria invasion on the prognosis of patients with bladder tumors. J Urol 124:23-26, 1980
3. Abel PD, Hall RR, Williams G: Should pTl transitional cell cancers of the bladder still be classified as superficial? Br J Urol 62:235-239, 1988
4. Herr HW, Jakse G, Sheinfeld J: T1 bladder tumor. Semin Urol 8:254-261, 1990
5. Stockle M, Alken P, Engelmann U, bt al: Radical cystectomy-often too late? Eur Urol 13:361-367, 1987
6. Levine AJ, Momand J, Finlay CA: The p53 tumour suppressor gene. Nature 351:453-456, 1991
7. Finlay CA, Hinds PW, Tan TH, et al: Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Mol Cell Biol 8:531-539, 1988
8. Marks JR, Davidoff AM, Kerns BJ, et al: Overexpression and mutation of p53 in epithelial ovarian cancer. Cancer Res 51:2979-2984, 1991
9. Wright C, Mellon K, Johnston P, et al: Expression of mutant p53, c-erbB-2 and the epidermal growth factor receptor in transitional cell carcinoma of the human urinary bladder. Br J Cancer 63:967-970, 1991
10. Fujimoto K, Yamada Y, Okajima E, et al: Frequent association of p53 gene mutation in invasive bladder cancer. Cancer Res 52:1393-1398, 1992
11. Sidransky D, Von Eschenbach A, Tsai YC, ET al: Identification of p53 gene mutations in bladder cancers and urine samples. Science 252:706-709, 1991
12. Cordon-Cardo C, Finstad CL, Bander NH, ET al: Immunoanatomic distribution of cytostructural and tissue-associated antigens in the human urinary tract. Am J Pathol 126:269-284, 1987
13. Banks L, Matlashewski G, Crawford L: Isolation of human-p53-specific monoclonal antibodies and their use in the studies of human p53 expression. Eur J Biochem 159:529-534, 1986
14. Reuter VE, Melamed MR: The lower urinary tract. 7n Diagnostic Surgical Pathology (Sternberg SS, ed). New York: Raven Press, 1989, pp 1355-1392
15. Kahn HA, Sempos CT: Follow-up studies: Person-years, in Statistical Methods in Epidemiology (Kahn HA, Sempos CT, eds). New York: Oxford Univ Press, 1989, pp 206-225
16. Peto R, Pike MC, Armitage P, et al: Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br J Cancer 35:1-39, 1977
17. Cox DR: Partial likelihood. Biometrika 62:269-279, 1975
18. Cunningham J, Lust JA, Schaid DJ, et al: Expression of p53 and 17p allelic loss in colorectal carcinoma. Cancer Res 52:1974-1980, 1992
19. Iggo R, Gatter K, Barter J, et al: Increased expression of mutant forms of p53 oncogene in primary lung cancer. Lancet 335:675-679, 1990
20. Addison C, Jenkins JR, Sturzbecher HW: The p53 nuclear localisation signal is structurally linked to a p34°kinase motif Oncogene 5:423-426, 1990
21. Hollstein M, Sidransky D, Vogelstein B, et al; p53 mutations in human cancers. Science 253:49-53, 1991
22. Kerns BJ, Jordan PA, Moore MB, et al: p53 overexpression in formalin-fixed, paraffin-embedded tissue detected by immu-nohistochemistry. J Histochem Cytochem 40:1047-1051, 1991
23. Maestro R, Dolcetti R, Gasparotto D, et al: High frequency of p53 gene alterations associated with protein overexpression in human squamous cell carcinoma of the larynx. Oncogene 7:1159-1166, 1992.