Immunohistochemical detection of p53 and bcl‐2 proteins in non‐Hodgkin's lymphoma

Histopathology

Volumn 22, Issue 1, 1993, Pages 39-44

  PEZZELLA, F ^a   MORRISON, H ^a   JONES, M ^a   GATTER, K C ^a   LANE, D ^b   HARRIS, A L ^a   MASON, D Y ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

bcl 2; non Hodgkin's lymphoma; p53

Indexed keywords

PROTEIN P53;

ARTICLE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL;

COMPARATIVE STUDY; HUMAN; IMMUNOENZYME TECHNIQUES; LYMPHOMA, NON-HODGKIN; PROTEIN P53; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SUPPORT, NON-U.S. GOV'T;

EID: 0027410094     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.1993.tb00067.x     Document Type: Article

References (36)

1. The p53 tumour suppressor gene
2. Mutant p53‐the commonest genetic abnormality in human cancer?
3. Refractoriness to chemotherapy and poor survival related to abnormalities of chromosome 17 and 7 in lymphoma
4. Expression of p53 in human leukemia and lymphoma
5. Immuno‐histochemical evidence of abnormal expression of the antioncogene‐encoded p53 phosphoprotein in Hodgkin's disease and CD30+ anaplastic lymphomas
6. Wild‐type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin‐6
7. Bcl‐2 is an inner mitochondrial membrane protein that blocks programmed cell death
8. The use of monoclonal antibodies in histopathological diagnosis
9. P53 mutations in colorectal cancer
10. Analysis of p53 expression in human tumours: an antibody raised against human p53 expressed in. Escherichia Coll
11. Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form
12. Monoclonal antibodies specific for simian virus SV40 tumor antigen
13. Isolation of human‐p53‐specific monoclonal antibodies and their use in the study of human p53 expression
14. Expression of bcl‐2 oncogene protein is not specific for the 14; 18 chromosomal translocation
15. Immunoenzymatic labelling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti‐alkaline phosphatase (APAAP complexes)
16. Calculating confidence intervals for relative risks, odds ratios, and standardised ratios and rates
17. Increased expression of mutant forms of p53 oncogene in primary lung cancer
18. Expression of the nuclear oncogene p53 in colon tumours
19. Mutations in the p53 gene occur in diverse human tumour types
20. P53 expression in breast cancer
21. P53 expression in colorectal tumors
22. Mutational hotspot in the p53 gene in human hepatocellular carcinomas
23. Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa
24. Expression of mutant p53 in melanoma
25. P53 mutations in human lymphoid malignancies: Association with Burkitt lymphoma and chronic lymphocytic leukemia
26. Increased expression of p53 protein in human leukemia cells
27. P53 antioncogene expression elevated in AML, CLL, and blast crisis CML
28. Rearrangements in the p53 gene in philadelphia chromosome positive chronic myelogenous leukemia
29. Mutations of the p53 gene in lymphoid leukemia
30. Constant denaturant gel electrophoresis as a rapid screening technique for p53 mutations
31. SV40‐53K antigen: a possible role for 53K in normal cells
32. Growth regulation of a cellular tumor antigen, p53, in non transformed cells
33. Different forms of p53 detected by monoclonal antibodies in non‐dividing and dividing lymphocytes
34. Monoclonal antibody analysis of p53 expression in normal and transformed cells
35. Protein synthesis required to anchor a mutant p53 protein which is temperature‐sensitive for nuclear transport