Localization of the chromosome 15 breakpoints and expression of multiple PML-RARα transcripts in acute promyelocytic leukemia: A study of 28 Chinese patients

Leukemia

Volumn 7, Issue 1, 1993, Pages 20-26

  Geng, Jie Ping ^a   Tong, Jian Hua ^a   Dong, Shuo ^a   Wang, Zhen Yi ^a   Chen, Sai Juan ^a   Chen, Zhu ^a,c   Zelent, Arthur ^b   Berger, Roland ^c   Larsen, Christian Jacques ^c  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; RETINOIC ACID BINDING PROTEIN; RNA DIRECTED DNA POLYMERASE;

ACUTE MYELOBLASTIC LEUKEMIA; ARTICLE; CHROMOSOME 15; CHROMOSOME BREAKAGE; CHROMOSOME TRANSLOCATION 15; CHROMOSOME TRANSLOCATION 17; DNA SEQUENCE; GENE FUSION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; SOUTHERN BLOTTING;

BASE SEQUENCE; CARRIER PROTEINS; CHINA; CHROMOSOMES, HUMAN, PAIR 15; CHROMOSOMES, HUMAN, PAIR 17; DNA, NEOPLASM; GENE EXPRESSION; GENES, STRUCTURAL; HUMAN; LEUKEMIA, PROMYELOCYTIC, ACUTE; MOLECULAR SEQUENCE DATA; PROTO-ONCOGENE PROTEINS; RECEPTORS, RETINOIC ACID; REGULATORY SEQUENCES, NUCLEIC ACID; RESTRICTION MAPPING; RNA, MESSENGER; RNA, NEOPLASM; SUPPORT, NON-U.S. GOV'T; TRANSCRIPTION FACTORS; TRANSLOCATION (GENETICS);

EID: 0027409955     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Huang ME, Ye YC, Chen SR, Chai JR, Lu JX, Zhao L, Gu LJ, Wang ZY. Use of all-irans-retinoic acid in treatment of acute promyelocytic leukemia. Blood 1988;72: 567-572.
2. Castaigne S, Chomienne C, Daniel MT, Ballerini P, Berger R, Fenaux P, Degos L. All-trans-retinoic acid as a differentiation therapy for acute promyelocytic leukemia; I. Clinical results. Blood 1990;76:1710-1717.
3. Warrell RP Jr, Frankel SR, Miller WH Jr, Scheinberg DA, Itri LM, Hittelman WN, Vyas R, Andreff AM, Tafudi A, Jakubowski A, Gabrilove J, Gordon MS, Dmitrovski E. Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). N Engl J Med 1991;324:1385-1393.
4. Larson RA, Kondo K, Vardiman JW, Butler AE, Golomb HM, Rowley JD. Evidence for a 15;17 translocation in every patient with acute promyelocytic leukemia. Am J Med 1984;76:827-841.
5. Lemons RS, Eilender D, Waldmann RA, Rebentisch M, Fej AK, Ledbetter DH, Wilman C, McConnell T, O'Connell P. Cloning and characterization of the t(15;17) translocation breakpoint region in acute promyelocytic leukemia. Genes Chromosomes Cancer 1990;2:79-85.
6. Borrow J, Goddard AD, Sheer D, Solomon E. Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science 1990;249: 1577-1580.
7. de Thé H, Chomienne C, Lanotte M, Degos L, Dejean A. The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor a gene to a novel transcribed locus. Nature 1990;347:558-561.
8. Longo L, Pandolfi PP, Biondi A, Rambaldi A, Mencareli A, LoCoco F, Diverio D, Pegoraro L, Avanzi G, Tabilio A, Donto E, Grignani F, Pelicci PG. Rearrangements and aberrant expression of the RARα gene in acute promyelocytic leukemia. J Exp Med 1990;172:1571-1575.
9. Chomienne C, Ballerini P, Balitrand N, Huang ME, Krawice I, Castaigne S, Fenaux P, Thiollais P, Dejean A, Degos L, de Thé H. The retinoic acid receptor alpha gene is rearranged in retinoic acid-sensitive promyelocytic leukemias. Leukemia 1990;4:802-807.
10. Alcalay M, Zangrilli D, Pandolfi PP, Longo L, Mencarelli A, Giacomucci A, Rocchi M, Biondi A, Rambaldi A, LoCoco F, Diverio D, Donti E, Grignani F, Pelicci PG. Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor a locus. Proc Natl Acad Sci USA 1991;88:1977-1981.
11. Chang KS, Trujillo JM, Ogura T, Castiglione CM, Kidd KK, Zhao S, Freireich EJ, Stass SA. Rearrangement of the retinoic acid receptor gene in acute promyelocytic leukemia. Leukemia 1991;5:200-204.
12. Chen Z, Chen SJ, Tong JH, Zhu YJ, Huang ME, Wang WC, Wu Y, Sun GL, Wang ZY, Larsen CJ, Berger R. The retinoic alpha receptor gene is frequently disrupted in its 5' part in Chinese patients with acute promyelocytic leukemia. Leukemia 1991;5:288-292.
13. Pandolfi PP, Grignani F, Alcalay M, Mencarelli A, Biondi A, LoCoco F, Grignani F, Pelicci PG. Structure and origin of the acute promyelocytic leukemia myl/ RARα cDNA and characterization of its retinoid-binding and transactivation properties. Oncogene 1991;8:1285-1292.
14. Kazikuka A, Miller WH Jr, Umesono K, Warrell RP, Franker SR, Murty VVVS, Dmitrovsky E, Evans RM. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARa with a novel putative transcription factor, PML. Cell 1991;66:663-674.
15. de Thé H, Lavau C, Marchio A, Chomienne C, Degos L, Dejean A. The PML-RARAa fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell 1991;66:675-684.
16. Chen SJ, Zhu YJ, Tong JH, Dong S, Huang W, Chen Y, Xiang WM, Zhang L, Li XS, Qian GQ, Wang ZY, Chen Z, Larsen CJ, Berger R. Rearrangements in the second intron of the RARA gene are present in a large majority of patients with acute promyelocytic leukemia and are used as molecular marker for retinoic-acid-induced leukemic cell differentiation. Blood 1991;78:2696-2701.
17. Goddard AD, Borrow J, Freemont PS, Solomon E. Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia. Science 1991;254:1371-1374.
18. Tong JH, Dong S, Geng JP, Huang W, Wang ZY, Sun GL, Chen SJ, Chen Z, Larsen CJ, Berger R. Molecular rearrangements of the MYL gene in acute promyelocytic leukemia (APL, M3) define a breakpoint cluster region as well as some molecular variants. Oncogene 1992;7: 311-316.
19. Kastner P, Ferez A, Lutz Y, Rochette-Egly C, Gaub M-P, Durand B, Lanotte M, Berger R, Chambon P. Structure, localization and transcriptional properties of two classes of retinoic acid receptor α fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins. EMBO J 1992; 11:629-642.
20. Chang KS, Stass SA, Chu D-T, Deaven LL, Trujillo JM, Freireich EJ. Characterization of a fusion cDNA (RARA/myl) transcribed from the t(15;17) translocation breakpoint in acute promyelocytic leukemia. Mol Cell Biol 1992;12:800-810.
21. Chen SJ, Chen Z, Chen A, Tong JH, Dong S, Wang ZY, Waxman S, Zelent A. Occurrence of distinct PML-RARα fusion isoforms in patients with acute promyelocytie leukemia detected by reverse transcriptase/polymerase chain reaction. Oncogene 1992;7:1223-1232.
22. Pandolfi PP, Alcalay M, Fagioli M, Zangrilli D, Mencarelli A, Diverio D, Biondi A, LeCoco F, Rambaldi A, Grignani F, Rochette-Egly C, Gaube M-P, Chambon P, Pelicci PG. Genomic variability and alternative splicing generate multiple PML/RARa transcripts that encode aberrant PML proteins and PML/RARa isoforms in acute promyelocytic leukemia. EMBO J 1992;11:1397-1407.
23. Dong S, Tong JH, Huang W, Wang ZY, Chen SJ, Chen Z, Geng JP, Chi ZW. Molecular study on the chromosome 15 breakpoints in the t(15;17) in acute promyelocytic leukemia. Science in China 1992: (series B) (in press).
24. Beato M. Gene regulation by steroid hormones. Cell 1989;58:335-344.
25. Chambon P, Zelent A, Petkovich M, Mendelsohn C, Leroy P, Krust A, Kastner P, Brand N. The family of retinoic acid nuclear receptors. In: Seurat JH ed. Retinoids: 10 years on. Basel: S. Karger, 1991, pp. 10-27,
26. Fragioli M, Alcalay M, Pandolfi PP, Venturini L, Mencarelli A, Simeone A, Acampora D, Grignani F, Pelicci PG. Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminal different protein isoforms. Oncogene 1992;7:1083-1091.
27. Sambrook J, Fritsch EF, Maniatis T, eds. Molecular cloning. A laboratory manual. 2nd ed, Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 1989.
28. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol chloroform extraction. Anal Biochem 1987;162:156-159.
29. Loh EY, Elliott JF, Cwirla S, Lanier LL, Davis MM. Polymerase chain reaction with single sided specificity : analysis of T cell receptor δ chain. Science 1989;243: 217-220.
30. Chen SJ, Chen Z, Font M-P, d'Auriol L, Larsen CJ, Berger R. Structural alterations of the BCR and ABL gene first intron: further evidence implicating Alu sequences in the chromosome translocation. Nucleic Acid Res 1989; 17:7631-7642.
31. Bernard O, Guglielmi P, Jonveaux P, Cherif D, Gisselbrecht S, Mauchauffé M, Larsen CJ, Berger R. Mathieu-Mahul D. Two distinct mechanisms for the SCI gene activation in the t(1;14) translocation of T-cell leukemia. Genes Chromosomes Cancer 1990; 1:194-208,
32. Sanger F, Nicklen S, Coulson A. DNA sequencing with chain terminating inhibitor. Proc Natl Acad Sci USA 1977;74:5463-5467.
33. Brand NJ, Petkovich M, Chambon P. Characterization of a functional promoter for the human retinoic acid receptor-alpha (hRAR-α). Nucleic Acids Res 1990;18 6799-6806.