Identification of Ras farnesyltransferase inhibitors by microbial screening

Proceedings of the National Academy of Sciences of the United States of America

Volumn 90, Issue 6, 1993, Pages 2281-2285

  Hara, M ^a   Akasaka, K ^a   Akinaga, S ^a   Okabe, M ^a   Nakano, H ^a   Gomez, R ^a   Wood, D ^a   Uh, M ^a   Tamanoi, F ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

antitumor activity; competitive inhibition; gpa1 mutant; manumycin

Indexed keywords

ANTINEOPLASTIC AGENT; MANUMYCIN; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; TRANSFERASE INHIBITOR;

ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG SENSITIVITY; FIBROSARCOMA; HUMAN CELL; MALE; MOUSE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; STREPTOMYCES;

ANIMALIA; SACCHAROMYCES CEREVISIAE; STREPTOMYCES;

EID: 0027409561     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.90.6.2281     Document Type: Article

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