Depletion of polyamines prevents the neurotrophic activity of the GABA-agonist THIP in cultured rat cerebellar granule cells

Neurochemical Research

Volumn 18, Issue 2, 1993, Pages 153-158

  Abraham, J H ^a   Hansen, G H ^a   Seiler, N ^b   Schousboe, A ^c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b SANOFI   (France)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Cerebellum; DFMO; GABA; granule cells; morphological development; polyamines

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; EFLORNITHINE; GABOXADOL; POLYAMINE; PUTRESCINE; SPERMIDINE; SPERMINE;

ANIMAL CELL; ARTICLE; CELL DENSITY; CELL LEVEL; CELL MATURATION; CEREBELLUM; CONTROLLED STUDY; CYTOPLASM; GOLGI COMPLEX; GRANULE CELL; MORPHOMETRICS; NEURITE; NEUROTROPISM; NONHUMAN; PRIORITY JOURNAL; RAT; ROUGH ENDOPLASMIC RETICULUM;

ANIMAL; BIOGENIC POLYAMINES; CELLS, CULTURED; CEREBELLUM; EFLORNITHINE; ISOXAZOLES; MICROSCOPY, ELECTRON; ORNITHINE DECARBOXYLASE; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T;

EID: 0027407102     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/BF01474678     Document Type: Article

References (40)

1. GABAergic transmission in the mammalian central nervous system
2. Neurotransmitters as developmental signals
3. Trophic effects of GABA on cerebellar granule cells in culture
4. GABA induces functionally active low-affinity GABA receptors on cultured cerebellar granule cells
5. GABA-agonists induce the formation of low-affinity GABA-receptors on cultured cerebellar granule cells via preexisting high affinity GABA receptors
6. GABA influences the ultrastructure composition of cerebellar granule cells during development in culture
7. The trophic effect of GABA on cerebellar granule cells is mediated by GABA-receptors
8. GABA agonist promoted formation of low affinity GABA receptors on cerebellar granule cells is restricted to early development
9. γ-Aminobutyric acid agonist-induced alterations in the ultrastructure of cultured cerebellar granule cells is restricted to early development
10. Differences between GABA receptor binding to membranes from cerebellum during postnatal development and from cultured cerebellar granule cells
11. GABA-benzodiazepine-barbiturate receptor interactions
12. GABA agonist induced changes in ultrastructure and GABA receptor expression in cerebellar granule cells is linked to hyperpolarization of the neurons
13. Effects of inhibitors of protein synthesis and intracellular transport on the γ-aminobutyric acid agonist-induced functional differentiation of cultured cerebellar granule cells
14. Role of polyamines in the control of cell proliferation and differentiation
15. Polyamines
16. Recent advances in the biochemistry of polyamines in eukaryotes
17. Regulation of cellular polyamines in mammals
18. Autoradiographic and histological studies of postnatal neurogenesis. III. Dating the time of production and onset of differentiation of cerebellar microneurons in rats
19. Ornithine decarboxylase activity in developing rat brain
20. Ornithine decarboxylase as a tool in developmental neurobiology
21. Impaired development of cerebellar cortex in rats treated postnatally with α-difluoromethylornithine
22. Role of ornithine decarboxylase and the polyamines in nervous system development: A review
23. Substrate-induced irreversible inhibition of α-aminocid decarbocylases. Application to glutamate, aromatic- l-α-aminocid and ornithine decarboxylases
24. Inhibition of basic amino acid decarboxylases involved in polyamine biosynthesis
25. The maintenance and identification of mouse cerebellar granule cells in monolayer culture
26. Preparation of cultures of mouse (rat) cerebellar granule cells
27. Neuronal cells from chick embryo cerebral hemispheres cultivated on polylysine-coated surfaces
28. Ontogenetic development of glutamate metabolizing enzymes in cultured cerebellar granule cells and in cerebellum in vivo
29. Glutamate as the neurotransmitter of cerebellar granule cells in the rat: Electrophysiological evidence
30. Quantitative methods in biology
31. Determination of polyamines and related compounds by reversed-phase high-performance liquid chromatography: Improved separation systems
32. Regional distribution of putrescine, spermidine and spermine in relation to the distribution of RNA and DNA in the rat nervous system
33. Inhibitors of polyamine biosynthesis: Cellular and in vivo effects on tumor proliferation
34. Polyamines affect growth of cultured rat cerebellar neurons in different sera
35. Effects of taurine on cell morphology and expression of low-affinity GABA receptors in cultured cerebellar granule cells
36. Decreased protein-synthetic activity is an early consequence of spermidine depletion in rat hepatoma tissue-culture cells
37. Polyamine requirement for polyribosome formation and protein synthesis in human lymphocytes
38. Polyamines and the development of isolated neurons in cell culture