Antidepressant- and cocaine-sensitive human serotonin transporter: Molecular cloning, expression, and chromosomal localization

Proceedings of the National Academy of Sciences of the United States of America

Volumn 90, Issue 6, 1993, Pages 2542-2546

  Ramamoorthy, Sammanda ^a   Bauman, Andrea L ^b   Moore, Kim R ^b   Han, Hong ^c   Yang Feng, Teresa ^c   Chang, Albert S ^d   Ganapathy, Vadivel ^a   Blakely, Randy D ^b  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b EMORY UNIVERSITY   (United States)

^c YALE UNIVERSITY   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Biogenic amine uptake; Paroxetine; Placenta)

Indexed keywords

RODENTIA;

3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; AMITRIPTYLINE; ANTIDEPRESSANT AGENT; COCAINE; COMPLEMENTARY DNA; DESIPRAMINE; DEXAMPHETAMINE; FLUOXETINE; IMIPRAMINE; NOMIFENSINE; PAROXETINE; SEROTONIN;

AMINO ACID SEQUENCE; ARTICLE; BRAIN TISSUE; CHROMOSOMAL LOCALIZATION; CONCENTRATION RESPONSE; DRUG SENSITIVITY; DRUG UPTAKE; GENE MAPPING; HELA CELL; HUMAN; HUMAN CELL; HYBRID CELL; IN SITU HYBRIDIZATION; MOLECULAR CLONING; NEUROPHARMACOLOGY; NORTHERN BLOTTING; OPEN READING FRAME; PLACENTA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN PROCESSING; SEROTONINERGIC TRANSMISSION; TISSUE DISTRIBUTION;

AMINO ACID SEQUENCE; ANTIDEPRESSIVE AGENTS; BASE SEQUENCE; BINDING, COMPETITIVE; BLOOD PLATELETS; CARRIER PROTEINS; CELL LINE; COCAINE; FEMALE; HELA CELLS; HUMAN; KINETICS; LUNG; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; NEURONS; OLIGODEOXYRIBONUCLEOTIDES; PLACENTA; POLY A; POLYMERASE CHAIN REACTION; PREGNANCY; RNA; RNA, MESSENGER; SEROTONIN; SODIUM; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFECTION; TROPHOBLASTS;

EID: 0027405191     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.90.6.2542     Document Type: Article

References (46)

1. Cooper, J. R., Bloom, F. E. & Roth, R. H. (1991) The Biochemical Basis of Neuropharmacology (Oxford Univ. Press, New York), 6th Ed., pp. 338-380.
2. Fozard, J. R., ed. (1989) The Peripheral Actions of 5-Hydroxytryptamine (Oxford Univ. Press, New York).
3. Ross, S. B. & Renyi, A. L. (1967) Life Sci. 6, 1407-1415.
4. Kuhar, M. J., Roth, R. H. & Aghajanian, G. K. (1972) J. Pharmacol. Exp. Ther. 181, 36-45.
5. O'Reilly, C. A. & Reith, M. E. A. (1988) J. Biol. Chem. 263, 6115-6121.
6. Marcusson, J. O. & Ross, S. B. (1990) Psychopharmacology 102, 145-155.
7. Marcusson, J. O., Anderson, A. & Bäckstrom, I. (1989) Psychopharmacology 99, 17-21.
8. Graham, D., Esnaud, H., Habert, E. & Langer, S. Z. (1989) Biochem. Pharmacol. 38, 3819-3826.
9. Blakely, R. D., Berson, H. E., Fremeau, R. T., Jr., Caron, M. G., Peek, M. M., Prince, H. K. & Bradley, C. C. (1991) Nature (London) 354, 66-70.
10. Hoffman, B. J., Mezey, E. & Brownstein, M. J. (1991) Science 254, 579-580.
11. Rudnick, G. (1977) J. Biol. Chem. 252, 2170-2174.
12. Balkovetz, D. F., Tiruppathi, C., Leibach, F. H., Mahesh, V. B. & Ganapathy, V. (1989) J. Biol. Chem. 264, 2195-2198.
13. Lee, S.-L. & Fanburg, B. L. (1986) Am. J. Physiol. 250, C761-C765.
14. Rudnick, G. & Nelson, P. J. (1978) Biochemistry 17, 4739-4742.
15. Humphreys, C. J., Levin, J. & Rudnick, G. (1988) Mol. Pharmacol. 33, 657-663.
16. Reith, M. E. A., Zimanyi, I. & O'Reilly, C. (1989) Biochem. Pharmacol. 38, 2091-2097.
17. Cool, D. R., Leibach, F. H. & Ganapathy, V. (1990) Biochemistry 29, 1818-1822.
18. Liu, Y., Peter, D., Roghani, A., Schuldiner, S., Prive, G. G., Eisenberg, D., Brecha, N. & Edwards, N. (1992) Cell 70, 539-551.
19. Fuller, R. W. & Wong, D. T. (1990) Ann. N.Y. Acad. Sci. 600, 69-80.
20. Ashton, H. (1987) Brain Systems, Disorders and Psychotropic Drugs (Oxford Univ. Press, New York), pp. 283-300.
21. Briley, M. S., Langer, S. Z., Raisman, R., Sechter, D. & Zarifan, E. (1980) Science 209, 303-305.
22. Stanley, M., Virgilio, J. & Gershon, S. (1982) Science 216, 1337-1339.
23. Bastani, B., Arora, R. & Meltzer, H. Y. (1991) Biol. Psychiatry 30, 131-139.
24. Amara, S. G. & Pacholczyk, T. P. (1991) Curr. Opin. Neurobiol. 1, 84-90.
25. Blakely, R. D. (1992) Curr. Opin. Psychol. 5, 69-73.
26. Cool, D. R., Leibach, F. H., Bhalla, V. K., Mahesh, V. B. & Ganapathy, V. (1991) J. Biol. Chem. 266, 15750-15757.
27. MacDonald, R. J., Swift, G. H., Przybyla, A. E. & Chirgwin, J. M. (1987) Methods Enzymol. 152, 219-227.
28. Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B. & Erlich, H. A. (1988) Science 238, 487-494.
29. Fremeau, R. T., Jr., Caron, M. G. & Blakely, R. D. (1992) Neuron 8, 915-926.
30. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Lab., Plainview, NY), 2nd Ed.
31. Horton, R. M., Hunt, H. D., Ho, S. N., Pullen, J. K. & Pease, L. R. (1989) Gene 77, 61-68.
32. Pacholczyk, T., Blakely, R. D. & Amara, S. G. (1991) Nature (London) 350, 350-354.
33. Blakely, R. D., Clark, J. A., Rudnick, G. & Amara, S. G. (1991) Anal. Biochem. 194, 302-308.
34. Cheng, Y. & Prusoff, W. H. (1973) Biochem. Pharmacol. 22, 3099-3108.
35. Yang-Feng, T. L., Floyd-Smith, G., Drouin, J. & Franke, U. (1985) Am. J. Hum. Genet. 37, 1117-1128.
36. Boja, J. W., Patel, A., Carrol, F. I., Rahman, M. A., Philip, A., Lewin, A. H., Kopajtic, T. A. & Kuhar, M. J. (1991) Eur. J. Pharmacol. 194, 133-134.
37. Kozak, M. (1986) Cell 44, 283-292.
38. Kyte, J. & Doolittle, R. F. (1982) J. Mol. Biol. 157, 105-132.
39. Von Heijne, G. (1983) Eur. J. Biochem. 133, 17-21.
40. Mayser, W., Betz, H. & Schloss, P. (1991) FEBS Lett. 295, 203-206.
41. Blakely, R. D., Moore, K. R. & Qian, Y. (1993) J. Gen. Physiol., in press.
42. Ganapathy, V., Kulanthaivel, P., Tiruppathi, C., Mahesh, V. B. & Leibach, F. H. (1989) J. Pharmacol. Exp. Ther. 251, 9-15.
43. Nelson, H., Mandiyan, S. & Nelson, N. (1990) FEBS Lett. 269, 181-184.
44. Myers, C. L., Lazo, J. S. & Pitt, B. R. (1989) Am. J. Physiol. 257, L253-L258.
45. Kennely, P. J. & Krebs, E. G. (1991) J. Biol. Chem. 266, 15555-15558.
46. Rifkin, L. & Gurling, H. (1991) in Biological Aspects of Affective Disorders, eds. Horton, R. & Katona, C. (Academic, New York), pp. 305-334.