The role of the CD28 receptor during T cell responses to antigen

Annual Review of Immunology

Volumn 11, Issue , 1993, Pages 191-212

  Linsley, Peter S ^a   Ledbetter, Jeffrey A ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

anergy; antigen presenting cell; B7; costimulation; immunosuppression; T cell activation; tyrosine kinase

Indexed keywords

CD28 ANTIGEN; CELL SURFACE RECEPTOR;

ANTIGEN PRESENTING CELL; CLONAL ANERGY; DENDRITIC CELL; HUMAN; HUMAN CELL; MACROPHAGE; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE;

EID: 0027403299     PISSN: 07320582     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.iy.11.040193.001203     Document Type: Review

References (111)

1. Bretscher, P., Cohn, M. 1970. A theory of self-nonself discrimination. Science 169: 1042-49
2. Janeway, C. A. 1989. Approaching the asymptope evolution and revolution in immunology. Cold Spring Harbor Symp. Quant. Biol. 54: 1-13
3. Lafferty, K. J., Prowse, S. J., Simeonovic, C. J. 1983. Immunobiology of tissue transplantation: A return to the passenger leukocyte concept. Annu. Rev. Immunol. 1: 143-73
4. Jenkins, M. K., Pardoll, D. M., Mizuguchi, J., Quill, H., Schwartz, R. H. 1987. T cell responsiveness in vivo and in vitro: Fine specificity of induction and molecular characterization of the unresponsive state. Immunol. Rev. 95: 113-35
5. Mueller, D. L., Jenkins, M. K., Schwartz, R. H. 1989. Clonal expansion vs functional clonal inactivation: A costimulatory pathway determines the outcome of T cell receptor occupancy. Annu. Rev. Immunol. 7: 445-80
6. van Seventer, G. A., Shimizu, Y., Shaw, S. 1991. Roles of multiple accessory molecules in T cell activation. Curr. Opin. Immunol. 3: 294-303
7. Hansen, J. A., Martin, P. J., Nowinski, R. C. 1980. Monoclonal antibodies identifying a novel T cell antigen of human lymphocytes. Immunogenetics 10: 247-60
8. Lum, L. G., Orcutt-Thordarson, N., Seigneuret, M. C., Hansen, J. A. 1982. In vitro regulation of immunoglobulin synthesis by T cell subpopulations defined by a new human T cell antigen (9.3). Cell Immunol. 72: 122-29
9. Damle, N. K., Mohagheghpour, N., Hansen, J. A., Engleman, E. G. 1983. Alloantigen-specific cytotoxic and suppressor T lymphocytes are derived from phenotypically distinct precursors. J. Immunol. 131: 2296-2300
10. Yamada, H., Martin, P. J., Bean, M. A. 1985. Monoclonal antibody 9.3 and anti-CD11 antibodies define reciprocal subsets of lymphocytes. Eur. J. Immunol. 15: 1164-68
11. + cells with a limited alloreactive T cell receptor repertoire. J. Immunol. 143: 2783-89
12. Turka, L. A., Ledbetter, J. A., Lee, K., June, C. H. Thompson, C. B. 1990. CD28 is an inducible T cell surface antigen that transduces a proliferative signal in CD3+ mature thymocytes. J. Immunol. 144: 1646-53
13. Gross, J. A., St. John, T., Allison, J. P. 1990. The murine homologue of the T lymphocyte antigen CD28. Molecular cloning and cell surface expression. J. Immunol. 144: 3201-10
14. Gross, J. A., Callas, E., Allison, J. P. 1992. Identification and distribution of the costimulatory receptor CD28 in the mouse. J. Immunol. 149: 380-88
15. Kozbor, D., Moretta, A., Messner, H. A., Moretta, L., Croce, C. M. 1987. Tp44 molecules involved in antigen-independent T cell activation are expressed on human plasma cells. J. Immunol. 138: 4128-32
16. Gmunder, H., Lesslauer, W. A. 1984. A 45-kDa human T cell membrane glycoprotein functions in the regulation of cell proliferative responses. Eur. J. Biochem. 142: 153-60
17. Ledbetter, J. A., Martin, P. J., Spooner, C. E., Wofsy, D., Tsu, T. T., Beatty, P. G., Gladstone, P. 1985. Antibodies to Tp67 and Tp44 augment and sustain proliferative responses of activated T cells. J. Immunol. 135: 2331-36
18. Hara, T., Fu, S. M., Hansen, J. A. 1985. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen). J. Exp. Med. 161: 1513-24
19. Weiss, A., Manger, B., Imboden, J. 1986. Surgery between the T3/antigen receptor complex and Tp44 in the activation of human T cells. J. Immunol. 137: 819-25
20. Pierres, A., Lopez, M., Cerdan, C., Nunes, J., Olive, D., Mawas, C. 1988. Triggering CD28 molecules synergize with CD2 (T 11.1 and T 11.2)-mediated T cell activation. Eur. J. Immunol. 18: 685-90
21. van Lier, R. A. W., Brouwer, M., Aarden, L. C. 1988. Signals involved in T cell activation. T cell proliferation induced through the synergistic action of anti-CD28, and anti-CD2 monoclonal antibodies. Eur. J. Immunol. 8: 167-72
22. Moretta, A., Pantaleo, G., Lopez-Botet, M., Moretta, L. 1985. Involvement of T44 molecules in an antigen-independent pathway of T cell activation. J. Exp. Med. 162: 823-38
23. Jung, G., Ledbetter, J. A., Müller-Eberhard, H. J. 1987. Induction of cytotoxicity in resting human T lymphocytes bound to tumor cells by antibody heteroconjugates. Proc. Natl. Acad. Sci. USA 84: 4611-15
24. Nijhuis, E. W. P., Kemenade, E. W., Figdor, C. G., van Lier, R. A. W. 1990. Activation and expansion of tumour-infiltrating lymphocytes by anti-CD3 and anti-CD28 monoclonal antibodies. Cancer Immunol. Immunother. 32: 245-50
25. June, C. H., Ledbetter, J. A., Linsley, P. S., Thompson, C. B. 1990. Role of the CD28 receptor in T cell activation. Immunol. Today 11: 211-16
26. Martin, P. J., Ledbetter, J. A., Morishita, Y., June, C. H., Beatty, P. J., Hansen, J. A. 1986. A 44 kDa cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes. J. Immunol. 136: 3282-87
27. Thompson, C. B., Lindsten, T., Ledbetter, J. A., Kunkel, S. L., Young, H. A., Emerson, S. J., Leiden, J. M., June, C. H. 1989. CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proc. Natl. Acad. Sci. USA 86: 1333-37
28. Ledbetter, J. A., Imboden, J. B., Schieven, G. L., Grosmaire, L. S., Rabinovitch, P. S., Lindsten, T., Thompson, C. B., June, C. H. 1990. CD28 ligation in T cell activation: evidence for two signal transduction pathways. Blood 75: 1531-39
29. van Kooten, C., Rensink, I., Pascual-Salcedo, D., van Oers, R., Aarden, L. 1991. Monokine production by human T cells; IL-1 production restricted to memory T cells. J. Immunol. 146: 2654-58
30. Cerdan, C., Martin, Y., Brailly, H., Courcoul, M., Flavetta, S., Costello, R., Mawas, C., Birg, F., Olive, D. 1991. IL-1 is produced by T lymphocytes activated via the CD2 plus CD28 pathways. J. Immunol. 146: 560-64
31. Guba, S. C., Stella, G., Turka, L. A., June, C. H., Thompson, C. B., Emerson, S. G.. 1989. Regulation of interleukin 3 gene induction in normal human T cells. J. Clin. Invest. 84: 1701-6
32. Lindsten, T., June, C. H., Ledbetter, J. A., Stella, G., Thompson, C. B. 1989. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244: 339-43
33. Fraser, J. D., Irving, B. A., Crabtree, G. R., Weiss, A. 1991. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science 251: 313-16
34. Williams, T. M., Moolten, D. M., Makni, H., Kim, H. W. Kant, J. A., Kamoun, M. 1992. CD28-stimulated IL-2 gene expression in Jurkat T cells occurs in part transcriptionally and is Cyclosporine-A sensitive. J. Immunol. 148: 2609-16
35. Verweij, C. L., Geerts, M., Aarden, L. A. 1991. Activation of interleukin-2 gene transcription via the T cell surface molecule CD28 is mediated through a NFkB-like response element. J. Biol. Chem. 266: 14179-82
36. Fraser, J. D., Newton, M. E., Weiss, A. 1992. CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation. J. Exp. Med. 175: 1131-34
37. Tong-Starksen, S. E., Luciw, P. A., Peterlin, B. M. 1989. Signaling through T lymphocyte surface proteins, TCR/CD3 and CD28, activates the HIV-I long terminal repeat. J. Immunol. 142: 702-7
38. Gruters, R. A., Otto, S. A., Al, B. J. M., Verhoeven, A. J., Verweij, C. L., van Lier, R. A. W., Miedema, F. 1991. Non-mitogenic T cell activation signals are sufficient for induction of human immunodeficiency virus transcription. Eur. J. Immunol. 21: 167-72
39. Aruffo, A., Seed, B. 1987. Molecular cloning of a CD28 cDNA by a high efficiency COS cell expression system. Proc. Natl. Acad. Sci. USA 84: 8573-77
40. Williams, A. F., Barclay, A. N. 1988. The immunoglobulin superfamily - Domains for cell surface recognition. Annu. Rev. Immunol. 6: 381-405
41. Lee, K. P., Taylor, C., Petryniak, B., Turja, L. A., June, C. H., Thompson, C. B. 1990. The genomic organization of the CD28 gene. Implications for the regulation of CD28 mRNA expression and heterogeneity. J. Immunol. 145: 344-52
42. Clark, G. J., Dallman, M. J. 1992. Identification of a cDNA encoding the rat CD28 homologue. Immunogenetics 35: 54-57
43. Brunet, J.-F., Denizot, F., Luciani, M.-F., Roux-Dosseto, M., Suzan, M., Mattei, M.-G., Golstein P. 1987. A new member of the immunoglobulin superfamily-CTLA-4. Nature 328: 267-70
44. Brunet, J.-F., Denizot, F., Golstein, P. 1988. A differential molecular biology approach for genes preferentially expressed in functional T lymphocytes: the CTLA genes. Immunol. Rev. 103: 21-36
45. Dariavach, P., Mattei, M.-G., Golstein, P., Lefranc, M.-P. 1988. Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains. Eur. J. Immunol. 18: 1901-5
46. Harper, K., Balzano, C., Rouvier, E., Mattei, M.-G. Luciani, M.-F., Golstein, P. 1991. CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence message expression, gene structure and chromosomal location. J. Immunol. 147: 1037-44
47. Lafage-Pochitaloff, M., Costello, R., Couez, D., Simonetti, J., Mannoni, P., Mawas, C., Olive, D. 1990. Human CD28 and CTLA-4 Ig superfamily genes are located on chromosome 2 at bands q33-q34. Immunogenetics 31: 198-201
48. Howard, T. A., Rochelle, J. M., Seldin, M. F. 1991. CD28 and CTLA-4, two related members of the Ig super gene family, are tightly linked on proximal mouse chromosome 1. Immunogenetics 33: 74-76
49. Golstein, P., Balzano, C., Buonavista, N., Rouvier, E., Lukinov, D. 1992. The human CTLA-4 lymphocyte activation molecule. FASEB 6: 1677
50. Damle, N. K., Hansen, J. A., Good, R. A., Gupta, S. 1981. Monoclonal antibody analysis of human T lymphocyte subpopulations exhibiting autologous mixed lymphocyte reaction. Proc. Natl. Acad. Sci. USA 78: 5096-98
51. Damle, N. K., Doyle, L. V., Grosmaire, L. S., Ledbetter, J. A. 1988. Differential regulatory signals delivered by antibody binding to the CD28 (Tp44) molecule during the activation of human T lymphocytes. J. Immunol. 140: 1753-61
52. Lesslauer, W., Koning, F., Ottenhoff, T., Giphart, M., Goulmy, E., van Rood, J. J. 1986. T90/44 (9.3 antigen). A cell surface molecule with function in human T cell activation. Eur. J. Immunol. 16: 1289-96
53. Linsley, P. S., Clark, E. A., Ledbetter, J. A. 1990. T cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc. Natl. Acad. Sci. USA 87: 5031-35
54. Freeman, G. J., Freedman, A. S., Segil, J. M., Lee, G., Whitman, J. F., Nadler, L. M. 1989. B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J. Immunol. 143: 2714-22
55. Linsley, P. S., Brady, W., Grosmaire, L., Aruffo, A., Damle, N. K., Ledbetter, J. A. 1991. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J. Exp. Med. 173: 721-30
56. Linsley, P. S., Brady, W., Urnes, M., Grosmaire, L. S., Damle, N. K., Ledbetter, J. A. 1991. CTLA-4 is a second receptor for the B cell activation antigen B7. J. Exp. Med. 174: 561-69
57. Linsley, P. S., Greene, J., Tan, P., Bradshaw, J., Ledbetter, J. A., Anasetti, C., Damle, N. K. 1992. Coexpression and functional cooperativity of CTLA-4 and CD28 on activated T lymphocytes. J. Exp. Med. In press
58. Yokochi, T., Holly, R. D., Clark, E. A. 1981. B lymphoblast antigen (BB-1) expressed on Epstein-Barr virus activated B cell blasts, B lymphoblastoid cell lines, and Burkitt's lymphomas. J. Immunol. 128: 823-27
59. Freedman, A. S., Freeman, G., Horowitz, J. C., Daley, J., Nadler, L. M. 1987. A B cell-restricted antigen that identifies preactivated B cells. J. Immunol. 139: 3260-67
60. Freeman, G. J., Gray, G. S., Gimmi, C. D., Lombard, D. B., Zhou, L.-J., White, M., Fingeroth, J. D., Gribben, J. G., Nadler, L. M. 1991. Structure, expression and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. J. Exp. Med. 174: 625-31
61. Liu, Y., Jones, B., Brady, W., Janeway, C. A. Jr., Linsley, P. S. 1992. Murine CD4 T cell growth: B7 and heat stable antigen both participate in co-stimulation. Eur. J. Immunol. In press
62. Katz, F. E., Parkar, M., Stanley, K., Murray, L. J., Clark, E. A., Greaves, M. F. 1985. Chromosomal mapping of cell membrane antigens expressed on activated B cells. Eur. J. Immunol. 15: 103-6
63. Freeman, G. J., Disteche, M. C., Gribben, J. G., Adler, D. A., Freedman, A. S., Dougery, J., Nadler, L. M. 1992. The gene for B7, a costimulatory signal for T cell activation, maps to chromosomal region 3q13.3-3q21. Blood 79: 489-94
64. Valle, A., Aubry, J.-P., Durand, I., Banchereau, J. 1991. IL-4 and IL-2 upregulate the expression of antigen B7, the B cell counterstructure to T cell CD28: An amplification mechanism for T-B cell interactions. Int. Immunol. 3: 229-35
65. Freedman, A. S., Freeman, G. J., Rhynhart, K., Nadler, L. M. 1991. Selective induction of B7/BB-1 on interferon-gamma stimulated monocytes: A potential mechanism for amplification of T cell activation through the CD28 pathway. Cell Immunol. 137: 429-37
66. Valle, A., Garrone, P., Yssel, H., Bonnefoy, J. Y., Freedman, A. S., Freeman, G. J., Nadler, L. M., Banchereau, J. 1992. MAb 104 a murine monoclonal antibody, recognizes the B7 antigen which is expressed on activated B cells and HTLV-1 transformed T cells. Immunology 6989: 531-35
67. Razi-Wolf, Z., Freeman, G. J., Galvin, F., Benacerraf, B., Nadler, L., Reiser, H. 1992. Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells. Proc. Natl. Acad. Sci. USA 89: 4210-14
68. Kohno, K., Shibata, Y., Matsuo, Y., Minowada, J. 1990. CD28 molecule as a receptor-like function for accessory signals in cell-mediated augmentation of IL-2 production. Cell Immunol. 131: 1-10
69. Gimmi, C. D., Freeman, G. J., Gribben, J. G., Sugita, K., Freedman, A. S., Morimoto, C., Nadler, L. M. 1991. B cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2. Proc. Natl. Acad. Sci. USA 88: 6575-79
70. + T lymphocytes. J. Immunol. 148: 1985-92
71. Azuma, M., Cayabyab, M., Buck, D., Phillips, J. H., Lanier, L. L. 1992. CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes. J. Exp. Med. 175: 353-60
72. + T cells. J. Exp. Med. 173: 759-62
73. Damle, N. K., Linsley, P. S., Ledbetter, J. A. 1991. Direct helper T cell-induced B cell differentiation involves interaction between T cell antigen CD28 and B cell activation antigen B7. Eur. J. Immunol. 21: 1277-82
74. Liu, Y., Janeway, C. A. Jr.. 1990. Interferon gamma plays a critical role in induced cell death of Th1 cells: A third mechanism of T cell tolerance. J. Exp. Med. 172: 1735-39
75. Jenkins, M. K., Taylor, P. S., Norton, S. D., Urdahl, K. B. 1991. CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells. J. Immunol. 147: 2461-66
76. Harding, F. A., McArthur, J. G., Gross, J. A., Raulet, D. H., Allison, J. P. 1992. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T cell clones. Nature 356: 607-9
77. Tan, P., Anasetti, C., Hansen, J. A., Ledbetter, J. A., Linsley, P. A. 1992. Induction of alloantigen specific hypo-responsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB-1. J. Exp. Med. In press
78. Groux, H., Torpier, G., Monte, D., Mouton, Y., Capron, A., Ameisen, J. C. 1992. Activation-induced death by apoptosis in CD4 T cells from human immunodeficiency virus-infected asymptomatic individual. J. Exp. Med. 175: 331-40
79. Damle, N. K., Klussman, K., Linsley, P. S., Aruffo, A., Ledbetter, J. A. 1992. Differential regulatory effects of ICAM-1 on costimulation by the CD28 counter-receptor B7. J. Immunol. 149: 2541-48
80. Shimizu, Y., van Seventer, G. A., Ennis, E., Newman, W., Horgan, K. J., Shaw, S. 1992. Cross-linking of the T cell-specific accessory molecules CD7 and CD28 modulates T cell adhesion. J. Exp. Med. 175: 577-82
81. Liu, Y., Janeway, C. A. Jr. 1992. Cells that present both T cell receptor ligand and the costimulator are most efficient inducer for clonal expansion of normal CD4 T cells. Proc. Natl. Acad. Sci. USA 89: 3845-49
82. Vandenberghe, P., Freeman, G. J., Nadler, L. M., Fletcher, M. C., Kamoun, M., Turka, L. A., Ledbetter, J. A., Thompson, C. B., June, C. H. 1992. Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells. J. Exp. Med. 175: 951-60
83. Lu, Y., Granelli-Piperno, A., Bjorndahl, J. M., Phillips, C. A., Trevillyan, J. M. 1992. CD28-inducted T cell activation. Evidence for a protein-tyrosine kinase signal transduction pathway. J. Immunol. 149: 24-29
84. Ledbetter, J. A., Schieven, G. L., Kanner, S. B., Brady, W., Grosmaire, L. S., Tsu, T. T., Deans, J. P., Bolen, J. B., Linsley, P. S. 1992. CD28 receptor ligation activates PLC gamma 1 and induces IL2 mRNA expression by a protein-tyrosine kinase-dependent pathway. Blood. Submitted
85. Linsley, P. S., Bradshaw, J., Urnes, M., Grosmaire, L., Ledbetter, J. A. 1992. CD28 engagement by B7/BB-1 induces transient downregulation of CD28 synthesis and prolonged unresponsiveness to CD28 signalling. J. Immunol. Submitted
86. June, C. H., Jackson, K. M., Ledbetter, J. A., Leiden, J. M., Lindsten, T., Thompson, C. B. 1989. Two distinct mechanisms of interleukin-2 gene expression in human T lymphocytes. J. Autoimmun. 2 (Suppl): 55-65
87. June, C. H., Ledbetter, J. A., Lindsten, T., Thompson, C. B. 1989. Evidence for the involvement of three distinct signals in the induction of IL-2 gene expression in human T lymphocytes. J. Immunol. 143: 153-61
88. Ledbetter, J. A., Parsons, M., Martin, P. J., Hansen, J. A., Rabinovitch, P. S., June, C. H.. 1986. Antibody binding to CD5 (Tp67) and Tp44 T cell surface molecules: effects on cyclic nucleotides, cytoplasmic free calcium, and cAMP-mediated suppression. J. Immunol. 137: 3299-3305
89. June, C. H., Ledbetter, J. A., Gillespie, M. M., Lindsten, T., Thompson, C. B. 1987. T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression. Mol. Cell. Biol. 7: 4472-81
90. Fruman, D. A., Klee, C. B., Bierer, B. E., Burakoff, S. J. 1992. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc. Natl. Acad. Sci. USA 89: 3686-90
91. Walsh, C. T., Zydowsky, L. D., McKeon, F. D. 1992. Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockage of T cell signal transduction. J. Biol. Chem. 267: 13115-18
92. O'Keefe, S. J., Tamura, J., Kincaid, R. L., Tocci, M. J., O'Neill, E. A: 1992. FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature 357: 692-94
93. Clipstone, N. A., Crabtree, G. R. 1992. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 357: 695-97
94. Bjorndahl, J. M., Sung, S.-S. J., Hansen, J. A., Fu, S. M. 1989. Human T cell activation: differential response to anti-cD28 as compared to anti-CD3 monoclonal antibodies. Eur. J. Immunol. 19: 881-87
95. Hess, A. D., Bright, E. C. 1991. The effect of the CD28 activation pathway on the immunosuppressive action of cyclosporine. Transplantation 51: 1232-40
96. Bierer, B. E., Schreiber, S. L., Burakoff, S. J. 1991. The effect of the immunosuppressant FK-506 on alternate pathways of T cell activation. Eur. J. Immunol. 21: 439-45
97. Furue, M., Ishibashi, Y. 1991. Differential regulation by dexamethasone and cyclosporine of human T cells activated by various stimuli. Transplantation 52: 522-26
98. Andersson, J., Nagy, S., Groth, C.-G., Andersson, U. 1992. Effects of FK506 and cyclosporin A on cytokine production studies in vitro at a single-cell level. Immunology 75: 136-42
99. Kay, J. E., Benzie, C. R. 1990. T lymphocyte activation through the CD28 pathway is insensitive to inhibition by the immunosuppressive drug FK-506. Immunol. Lett. 23: 155-60
100. van Lier, R. A. W., Brouwer, M., De Groot, E., Kramer, I., Aarden, L. A., Verhoeven, A. J. 1991. T cell receptor/CD3 and CD28 use distinct intracellular signaling pathways. Eur. J. Immunol. 21: 1775-78
101. Lindstein, T., June, C. H., Ledbetter, J. A., Stella, G., Thompson, C. B. 1989. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244: 339-43
102. Ledbetter, J. A., June, C. H., Grosmaire, L. S., Rabinovitch, P. S. 1987. Cross-linking of surface antigens causes mobilization of intracellular ionized calcium in T lymphocytes. Proc. Natl. Acad. Sci. USA 84: 1384-88
103. Ledbetter, J. A., Tonks, N. K., Fischer, E. H., Clark, E. A. 1988. CD45 regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T or B cells. Proc. Natl. Acad. Sci. USA 85: 8628-32
104. Granelli-Piperno, A., Nolan, P., Inaba, K., Steinman, R. M. 1990. The effect of immunosuppressive agents on the induction of nuclear factors that bind to sites on the interleukin 2 promoter. J. Exp. Med. 172: 1869-72
105. Nunes, J., Bagnasco, M., Lopez, M., Lipcey, C., Mawas, C., Olive, D. 1991. Dissociation between early and late events in T cell activation mediated through CD28 surface molecule. Mol. Immunol. 28: 427-35
106. Chouaib, S., Welte, K., Mertelsmann, R. F., Dupont, B. 1985. Prostaglandin E2 acts as two distinct pathways of T lymphocyte activation: Inhibition of interleukin 2 production and down-regulation of transferrin receptor expression. J. Immunol. 135: 1172-79
107. Goodwin, J. S., Bromberg, S., Messner. R. P. 1981. Studies on the cyclic AMP response to prostaglandin in human lymphocytes. Cell Immunol. 60: 298-307
108. Novogrodsky, A., Patya, M., Rubin, A. L., Stenzel, K. H. 1983. Agents that increase cellular cAMP inhibit production of interleukin-2, but not its activity. Biochem. Biophys. Res. Commun. 114: 93-98
109. Rappaport, R. S., Dodge, G. R. 1982. Prostaglandin E inhibits the production of human interleukin 2. J. Exp. Med. 155: 943-48
110. Linsley, P. S., Wallace, P. M., Johnson, J., Gibson, M. G., Greene, J., Ledbetter, J. A., Singh, C., Tepper, M. 1992. Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science. 257: 792-95
111. Lenschow, D. J., Zeng, Y., Thistlewaite, J. R., Montag, A., Brady, W., Gibson, M. G., Linsley, P. S., Bluestone, J. A. 1992. Long-term survival of xenogeneic pancreatic islets induced by CTLA41g. Science. 257: 789-92