Stimulation of insulin secretion by the imidazoline α2-adrenoceptor antagonist efaroxan is mediated by a novel, stereoselective, binding site

European Journal of Pharmacology

Volumn 230, Issue 3, 1993, Pages 375-378

  Chan, Susan L F ^a   Brown, Colin A ^a   Morgan, Noel G ^a  

^a KEELE UNIVERSITY   (United Kingdom)

Author keywords

Imidazoline; Islets of Langerhans; K+ channels; RX821002; RX851034; 2 Adrenoceptors

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; BRIMONIDINE; DIAZOXIDE; EFAROXAN; IMIDAZOLINE RECEPTOR; PHENTOLAMINE; RX 851033; RX 851034; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; INSULIN RELEASE; MALE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; RAT; STEREOSPECIFICITY;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMAL; BENZOFURANS; DOSE-RESPONSE RELATIONSHIP, DRUG; IMIDAZOLES; INSULIN; ISLETS OF LANGERHANS; MALE; RATS; RATS, WISTAR; STEREOISOMERISM; SUPPORT, NON-U.S. GOV'T; TISSUE CULTURE;

EID: 0027400144     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(93)90577-5     Document Type: Article

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