The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

Cell

Volumn 72, Issue 2, 1993, Pages 291-300

  Aruffo, Alejandro ^a,b   Farrington, Mary ^b   Hollenbaugh, Diane ^a   Li, Xu ^c   Milatovich, Athena ^c   Nonoyama, Shigeaki ^b   Bajorath, Jürgen ^a   Grosmaire, Laura S ^a   Stenkamp, Ronald ^b   Neubauer, Michael ^a   Roberts, Robert L ^d   Noelle, Randolph J ^e   Ledbetter, Jeffrey A ^a   Francke, Uta ^c   Ochs, Hans D ^b  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^d UCLA MEDICAL CENTER   (United States)

^e DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE ANTIGEN; CELL SURFACE PROTEIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MESSENGER RNA;

ANTIBODY PRODUCTION; ANTIGEN ANTIBODY REACTION; ARTICLE; B LYMPHOCYTE; CHROMOSOMAL LOCALIZATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMORAL IMMUNE DEFICIENCY; LYMPHOCYTE PROLIFERATION; MALE; MUTATION; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; X CHROMOSOME LINKED DISORDER;

ADOLESCENT; ADULT; AMINO ACID SEQUENCE; ANTIGENS, CD; ANTIGENS, CD40; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; B-LYMPHOCYTES; BASE SEQUENCE; BLOTTING, NORTHERN; CD40 LIGAND; CHROMOSOME MAPPING; DNA; HUMAN; HYPERGAMMAGLOBULINEMIA; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOGLOBULIN SWITCH REGION; IMMUNOLOGIC DEFICIENCY SYNDROMES; LYMPHOCYTE ACTIVATION; MALE; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; OLIGODEOXYRIBONUCLEOTIDES; PROTEIN STRUCTURE, SECONDARY; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; T-LYMPHOCYTES; X CHROMOSOME;

EID: 0027394391     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(93)90668-G     Document Type: Article

References (47)

1. Molecular and biological characterization of a murine ligand for CD40
2. A method to identify protein sequences that fold into a known three-dimensional structure
3. Prediction of the folding of short polypeptide segments by uniform conformational sampling
4. Structure of antibody hypervariable loops reproduced by a conformational search algorithm
5. Un exemple d'agammaglobulinemie atypique (un cas de grande hypogammaglobulinémie avec augmentation de la β2-macroglobuline)
6. Regulation of human B-cell activation and adhesion
7. Activation of human B cells mediated through two distinct cell surface differentiation antigen, Bp35 and Bp50
8. Interleukin 10 and transfection growth factor β cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin
9. The structure of tumor necrosis factor-alpha at 2.6 Å resolution
10. The structure of human lymphotoxin (tumor necrosis factor-β) at 1.9-Å resolution
11. Soluble forms of CD40 inhibit biological responses of human B cells
12. Emerging cytokine family
13. CD40 is functionally expressed on human thymic epithelial cells
14. + T cell clones and IL-4 induce IgG4 and IgE switching in purified human B cells via different signaling pathways
15. A novel GC-rich human macrosatellite VNTR in Xq24 is differentially methylated on active and inactive X chromosomes
16. Synergistic interaction between interleukin 4 and anti-Bp50 (CDw40) revealed in a novel B cell restimulation assay
17. The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity
18. CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells
19. Structure of tumor necrosis factor
20. Activated human T cells express a ligand for the human V cell-associated antigen CD40 which participates in T cell-dependent activation of B lymphocytes
21. Assessment of protein models with three-dimensional profiles
22. Evidence for a defect in “switch” T cells in patients with immunodeficiency and hyperimmunoglobulinemia M
23. X-linked immunodeficiency with hyperimmunoglobulinemia M appears to be linked to the DXS42 restriction fragment length polymorphism locus
24. Gene for lymphoid enhancer-binding factor 1 (LEF1) mapped to human chromosome 4 (q23-q25) and mouse chromosome 3 near Egf
25. Extensive analysis of tissue distribution of antigens defined by new clustered and unclustered B-cell antibodies
26. A 39-KDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells
27. CD40 and its ligand and essential ligand-receptor pair for thymus-dependent B-cell activation
28. Immunodeficiency with hyper-IgM (HIM)
29. Disorders of the B cell system
30. Immunologic responses to bacteriophage øX174 in immunodeficiency disease
31. Mapping of the X-linked form of hyper-IgM syndrome (HIGM1) to Xq26 by close linkage to HPRT
32. Ap50 surface antigen restricted to human urinary bladder carcinomas and B lymphocytes
33. c receptor for IgG mediates anti-CD3 dependent lymphoproliferation
34. Tertiary templates for proteins
35. The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukemia
36. Recurrent bacterial infections and dysgammaglobulinemia: deficiency of 7S gammaglobulins in the presence of elevated 19S gammaglobulins
37. Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigens
38. Molecular analysis of the induction of immunoglobulin E synthesis in human B cells by interleukin 4 and engagement of CD40 antigen
39. Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion
40. A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas
41. Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex
42. Variability in the expression of X-linked agammaglobulinemia: the co-existence of classic X-LA (Bruton type) and “common variable immunodeficiency” in the same families
43. Toward a complete linkage map of the human X chromosome: regional assignment of 16 cloned single-copy DNA sequences employing a panel of somatic cell hybrids
44. Genes for synapsin I, a neuronal phosphoprotein, map to conserved regions of human and murine X chromosomes
45. CD40 stimulation provides an IFN independent and IL-4-dependent differentiation signal directly to human B cells for IgE production
46. Site-directed mutational analysis of human tumor necrosis factor-α receptor binding site and structure-functional relationship