Acceleration of tissue repair by transforming growth factor β1: Identification of in vivo mechanism of action with radiotherapy-induced specific healing deficits

Surgery

Volumn 113, Issue 1, 1993, Pages 36-42

  Cromack, Douglas T ^a,b   Porras Reyes, Beatriz ^a,b   Purdy, James A ^a,b   Pierce, Glenn F ^a,b   Mustoe, Thomas A ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DRUG MECHANISM; FIBROBLAST; HISTOLOGY; IMMUNOHISTOCHEMISTRY; LEUKOCYTE COUNT; MALE; NONHUMAN; PRIORITY JOURNAL; RADIATION INJURY; RAT; TISSUE REGENERATION; TOPICAL DRUG ADMINISTRATION; WHOLE BODY RADIATION; WOUND HEALING;

ANIMALS; HEMATOPOIESIS; MALE; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA; WHOLE-BODY IRRADIATION; WOUND HEALING;

EID: 0027392550     PISSN: 00396060     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Some recent advances in the chemistry and biology of transforming growth factor-beta
2. The TGF-β family of growth and differential factors
3. Transforming growth factor-β levels in rat wound chambers
4. Transforming growth factor type β induces monocyte chemotaxis and growth factor production
5. Transforming growth factor-β stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix
6. Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor β
7. Accelerated healing of incisional wounds in rats induced by transforming growth factor-β
8. Reversal of Adriamycin-impaired wound healing by transforming growth factorbeta
9. Transforming growth factor-β reverses the glucocorticoid-induced wound-healing deficit in rats: possible regulation in macrophages by platelet-derived growth factor
10. Quantitative analysis of inflammatory cell influx, procollagen type I synthesis, and collagen cross-linking in incisional wounds: influence of growth factor therapy
11. Platelet-derived growth factor and transforming growth factor-β enhance tissue repair activities by unique mechanisms
12. Reversal of impaired wound healing in irradiated rats by platelet-derived growth factor-BB
13. The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulation in the rat recognized by monoclonal antibodies ED1, ED2, and ED3
14. Rat thymus macrophages: an immunohistochemical study on fetal neonatal and adult thymus
15. Growth factor induced acceleration of tissue repair through direct and inductive activities in a rabbit dermal model
16. Exogenous transforming growth factor-beta 2 enhances connective tissue formation and wound strength in guinea pig dermal wound healing by secondary intent
17. Growth factors in wound healing: single and synergistic effects on partial thickness porcine skin wounds
18. Transforming growth factor beta (TGF-β) induces fibrosis in a fetal wound model
19. Transforming growth factor type-beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro
20. The reversal of an Adriamycin induced healing impairment with chemoattractants and growth factors
21. Transforming growth factor-β stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix
22. Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor beta
23. Differential acceleration of healing of surgical incisions in the rabbit gastrointestinal tract by platelet-derived growth factor and transforming growth factor type beta
24. The role of the macrophage in wound repair