A Single Amino Acid Difference Accounts for the Pharmacological Distinctions Between the Rat and Human 5‐Hydroxytryptamine1B Receptors

Journal of Neurochemistry

Volumn 60, Issue 1, 1993, Pages 380-383

  Parker, Eric M ^a   Grisel, Darcy A ^a   Iben, Lawrence G ^b   Shapiro, Robert A ^b  

^a Department of Biophysics and Molecular Biology ^*  (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

5 HT1B receptor; 5 HT1D receptor; 5 Hydroxytryptamine; Receptor; Serotonin

Indexed keywords

3 (1,2,5,6 TETRAHYDRO 4 PYRIDYL)PYRROLO[3,2 B]PYRIDIN 5 ONE; CYANOIODOPINDOLOL; METERGOLINE; METHYSERGIDE; PINDOLOL; PROPRANOLOL; RAUWOLSCINE; SEROTONIN 1B RECEPTOR; SUMATRIPTAN; TRYPTAMINE DERIVATIVE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; HUMAN; LIGAND BINDING; MUTANT; NONHUMAN; PHARMACOLOGY; PRIORITY JOURNAL; RAT; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMAL; BINDING, COMPETITIVE; HUMAN; IODOCYANOPINDOLOL; MUTAGENESIS, INSERTIONAL; PINDOLOL; RATS; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN AGONISTS;

ANIMALIA;

EID: 0027389653     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.1993.tb05865.x     Document Type: Article

References (18)

1. 1Dβ, receptor
2. Cloning, structure, and expression of the mitochondrial cytochrome P‐450 sterol 26‐hydroxylase, a bile acid biosynthetic enzyme
3. Subtypes of receptors for serotonin
4. 1A receptors
5. 1D receptor genes
6. Species differences in the pharmacology of terminal 5‐HT autoreceptors in mammalian brain
7. 2 receptor from a human to a rat pharmacology
8. 1B receptor ligand
9. Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes
10. Adenylyl cyclase amino acid sequence: possible channel‐ or transporter‐like structure
11. 1D‐like sites in guinea pig brain
12. LIGAND: a versatile computerized approach for the characterization of ligand binding systems
13. DNA sequencing with chain‐terminating inhibitors
14. Identification of residues required for ligand binding to the β‐adrenergic receptor
15. 2 adrenergic receptor increases its affinity for a family of β receptor antagonists
16. 1B receptor
17. 1Dβ