Effect of diazepam on cortical 5-HT release and behaviour in the guinea-pig on exposure to the elevated plus maze

Psychopharmacology

Volumn 110, Issue 4, 1993, Pages 490-496

  Rex, A ^a   Marsden, C A ^a   Fink, H ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

5 HT; Diazepam; Elevated plus maze; Flumazenil; Guinea pig

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; ANXIOLYTIC AGENT; DIAZEPAM; FLUMAZENIL; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; BRAIN CORTEX; CONTROLLED STUDY; DRUG ANTAGONISM; FEMALE; GUINEA PIG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAPERITONEAL DRUG ADMINISTRATION; MAZE TEST; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; SEROTONIN RELEASE;

ANIMAL; ANXIETY; BEHAVIOR, ANIMAL; DIAZEPAM; EXPLORATORY BEHAVIOR; EXTRACELLULAR SPACE; FEMALE; FLUMAZENIL; GUINEA PIGS; HYDROXYINDOLEACETIC ACID; MICRODIALYSIS; PREFRONTAL CORTEX; SEROTONIN; SUPPORT, NON-U.S. GOV'T;

EID: 0027389222     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/BF02244657     Document Type: Article

References (51)

1. An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat
2. The duration of tonic immobility in guinea pigs
3. Effects of GABA and diazepam on [3H] - serotonin release from hippocampal synaptosomes
4. Behaviour of pet animals
5. Handling-habituation prevents the effects of diazepam and alpralozam on brain serotonin levels in rats
6. Chronic handling modifies the anxiolytic effect of diazepam in the elevated plus-maze
7. Serotonin release estimated by transcortical dialysis in freely moving rats
8. Differential actions of diazepam on the release of [3H] 5-hydroxytryptamine from cortical and midbrain raphe slices in the rat
9. Behavioural evidence for partial agonist properties of Ro 15–1788, a benzodiazepine receptor antagonist
10. 5-HT and mechanisms of defence
11. Effect of benzodiazepine compounds on brain amine metabolism
12. Midalozam-induced increase in NaCl solution ingestion: differential effect of the benzodiazepine antagonists Ro 15–1788 and CGS 8216
13. The anxiogenic action of Ro 15–1788 is reversed by chronic, but not by acute, treatment with chlordiazepoxide
14. The anxiogenic action of benzodiazepine antagonists
15. Intrinsic actions of benzodiazepine antagonists
16. Benzodiazepine: potentation of a GABA inhibitory response in dorsal raphe nucleus
17. Tryptamine mechanism in punished and nonpunished behaviour
18. Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of “fear”-motivated behaviour
19. Chronic diazepam treatment in rats causes long-lasting changes in central [3H]-5-hydroxytryptamine and [14C]-g-aminobutyric acid release
20. Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brain
21. Terminal autoreceptor control of 5-hydroxytryptamine as measured by in vivo microdialysis in the conscious guinea-pig
22. Modulation of electrically evoked release of 5-[3H] hydroxytryptamine from rat cerebral cortex: effect of alpidem, CL 218872 and diazepam
23. Benzodiazepine receptors modulate 5-hydroxytryptamine neurotransmission in the rat hippocampus: in vivo electrophysiological evidence
24. The use of a plus-maze to measure anxiety in the mouse
25. Changes in regional concentrations in the rat brain of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid during the development of tolerance to the sedative action of chlordiazepoxide
26. In vivo monitoring of pharmacological and physiological changes in endogenous serotonin release and metabolism
27. Application of intracerebral dialysis and in vivo voltametry to pharmacological and physiological studies of amine neurotransmitters
28. gamma-Aminobutyric acid A receptor heterogeneity in rat central nervous system: studies with clonazepam and other benzodiazepine ligands
29. The relation between fear induced by novel stimulation and exploratory behaviour
30. GABA-benzodiazepine-barbiturate receptor interactions
31. Both systemic and local administration of benzodiazepine agonist inhibit the in vivo release of 5-HT from the ventral hippocampus
32. Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat
33. Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
34. Effects of the benzodiazepine receptor agonist midazolam and antagonist flumazenil on 5-hydroxytryptamine release from guinea-pig intestine in vitro. Indirect support for a “natural” benzodiazepine-like substance in the intestine
35. Distribution of catecholamines and serotonin in the rat cerebral cortex: absolute levels and relative proportions
36. A benzodiazepine antagonist is an anticonvulsant in an animal model for limbic epilepsy
37. Effect of diazepam on cerebral 5-hydroxytryptamine synthesis
38. A water-maze test of learning ability for guinea-pigs
39. Chlordiazepoxide reduces in vivo serotonin release in the basal ganglia of encephacele isole but not anaesthetized cats: evidence for a dorsal raphe site of action
40. Anti-anxiety action of benzodiazepines: decrease in activity of serotonin neurons in the punishment system
41. Raphe unit activity in freely moving cats: effects of benzodiazepines
42. Dopamin synaptic mechanisms reflected in studies combining behavioural recordings and brain dialysis
43. 5-HT1D receptors in guinea pig and pidgeon brain. Radioligand binding and biochemical studies
44. Benzodiazepines: anxiety-reducing reducing activity by reduction of serotonin turnover in the rat brain
45. Effect of established and putative anxiolytics on extracellular 5-HT and 5-HIAA in the ventral hippocampus of rats during behaviour on the elevated X-maze
46. Anatomy of the neocortex: neurochemical organization