Changes in Heat Shock Protein 70 and Ubiquitin mRNA Levels in C1300 N2A Mouse Neuroblastoma Cells Following Treatment with Iron

Journal of Neurochemistry

Volumn 60, Issue 2, 1993, Pages 659-665

  Uney, James B ^a   Anderton, Brian H ^a   Thomas, Siân M ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Free radicals; Heat shock proteins; Neuroblastoma cells; Neurodegeneration; Parkinson's disease; Ubiquitin

Indexed keywords

FREE RADICAL; HEAT SHOCK PROTEIN; IRON; MESSENGER RNA; UBIQUITIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; HEAT STROKE; HELA CELL; MOUSE; NEUROBLASTOMA CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN INDUCTION; RNA ANALYSIS;

ANIMAL; BIOLOGICAL TRANSPORT; BLOTTING, NORTHERN; CELL SURVIVAL; DEFEROXAMINE; HEAT-SHOCK PROTEINS; HELA CELLS; HUMAN; IRON; LACTATE DEHYDROGENASE; LYSOSOMES; MICE; MITOCHONDRIA; NEUROBLASTOMA; NEUTRAL RED; RNA, MESSENGER; RNA, NEOPLASM; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED; UBIQUITINS; VITAMIN E;

EID: 0027389083     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.1993.tb03198.x     Document Type: Review

References (54)

1. Abnormal proteins serve as eukaryotic stress signals and trigger the activation of heat shock genes
2. Mitochondrial proteins essential for viability mediate protein import into yeast mitochondria
3. Toxicity determined in vitro by morphological alterations and neutral red absorption
4. CNS trauma and stroke. 1: Biochemical considerations for oxygen radical formation and lipid peroxidation
5. Induction of a heat shock gene at the site of tissue injury in the rat brain
6. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
7. 70k heat shock related proteins stimulate protein translocation into microsomes
8. Number and evolutionary conservation of alpha and beta tubulin and cytoplasmic beta and gamma actin genes using specific cloned cDNA probes
9. Active oxygen in neuromuscular disorders
10. A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor proteins
11. Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease
12. Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease
13. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Addendum
14. Energy dependent accumulation of iron by isolated rat liver mitochondria; requirement for reducing equivalents and evidence for a unidirectional flux of Fell across the inner membrane
15. Ubiquitin mRNA is a major stress‐induced transcript in mammalian cells
16. Ubiquitous variations in nerves
17. Protein folding in the cell
18. Heat‐induced protein dephosphorylation in Chinese hamster ovary cells
19. Cultured animal cells exposed to amino acid analogues or puromycin rapidly synthesise several polypeptides
20. Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an x‐ray microanalysis
21. Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70
22. Microinjection of calcium‐calmodulin causes a local depolymerization of microtubules
23. Glutathione peroxidase activity in Parkinson's disease
24. Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study
25. Inhibition of heat shock response and synthesis of glucose‐related proteins in calcium‐deprived rat hepatomas
26. Transcriptional induction of the ubiquitin gene during herpes simplex virus infection is dependent upon viral immediate‐early protein ICP4
27. Abnormal proteins as the trigger for the induction of stress responses: heat, diamide, and sodium arsenite
28. Ubiquitin deposits in anterior horn cells in motor neurone disease
29. New aspects of the pathology of neurodegenerative disorders as revealed by ubiquitin antibodies
30. Diffuse Lewy body disease: correlative neuropathology using anti‐ubiquitin immunocytochemistry
31. A filamentous inclusion body within anterior horn neurones in motor neurone disease defined by immunocytochemical localisation of ubiquitin
32. Impairment of protein ubiquitination may cause delayed neuronal death
33. 70‐Kilodalton heat shock protein induction in cerebellar astrocytes and cerebellar granule cells in vitro: comparison with immunocytochemical localization after hyperthermia in vivo
34. Sequencing end‐labelled DNA with base‐specific chemical cleavages
35. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
36. Induction of the major inducible 68kDa heat shock protein after rapid changes of extracellular pH in cultured rat astrocytes
37. Synthesis of a stress protein following transient ischemia in the gerbil
38. Heat shock RNA levels in brain and other tissues after hypethermia and transient ischemia
39. Speculations on the functions of the major heat shock and glucose‐regulated proteins
40. Parkinson's disease: a disorder due to nigral glutathione deficiency
41. Monoamine oxidase activity and monoamine metabolism in brains of parkinsonian patients treated with l‐deprenyl
42. Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains
43. Standardisation of isoenzyme assays with special reference to lactate dehydrogenase isoenzyme electrophoresis
44. A selective increase in particulate superoxide dismutase activity in parkinsonian substantia nigra
45. Free radicals and brain damage
46. Selective induction of a heat shock gene in fibre tracts and cerebellar neurons of the rabbit brain detected by in situ hybridisation
47. Effects of methylphenyl‐pyridinium and kainic acid on protein degradation in differentiated neuroblastoma cultures
48. Effects of neurotoxins on neurone‐specific enolase and lactate dehydrogenase activity and leakage in neuroblastoma cells
49. Stereotaxic injection of kainic acid into the striaturn of rats induces synthesis of mRNA for heat shock protein 70
50. Studies on a possible relationship between alteration in the cytoskeleton and induction of heat shock protein synthesis in mammalian cells
51. Heat shock gene expression and cytoskeletal alterations in mouse neuroblastoma cells
52. Induction of stress protein hsp70 in nerve cells after status epilepticus in the rat
53. The cytoplasmic pH, ATP content and total protein synthesis rate during heat shock protein‐inducing treatments in yeast
54. Stress‐induced thermotolerance of the cytoskeleton of mouse neuroblastoma N2A cells and rat liver H35 hepatoma cells