Bleomycin, an Apoptosis-mimetic Drug That Induces Two Types of Cell Death Depending on the Number of Molecules Internalized

Cancer Research

Volumn 53, Issue 22, 1993, Pages 5462-5469

  Tounekti, Omar ^a   Pron, Geraldine ^a   Belehradek, Jean ^a   Mir, Lluis M ^a  

^a INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL DEATH; CHINESE HAMSTER; DRUG DETERMINATION; DRUG EFFECT; DRUG UPTAKE; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; APOPTOSIS; AURINTRICARBOXYLIC ACID; BLEOMYCIN; CELL DEATH; CELL LINE; COBALT; CYCLOHEXIMIDE; DNA; DNA DAMAGE; EGTAZIC ACID; ELECTRIC STIMULATION; ELECTROPHORESIS, AGAR GEL; FERROUS COMPOUNDS; FLOW CYTOMETRY; G2 PHASE; HAMSTERS; HUMAN; MICROSCOPY, ELECTRON; PERMEABILITY; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED;

EID: 0027385319     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Umezawa, H., Maeda, K., Takeuchi, T., and Okami, Y. New antibiotics, bleomycin A and B.J. Antibiot. (Tokyo) Ser. A., 19: 200-209, 1966.
2. Byrnes, R.W., Templin, J., Sem, D., Lyman, S., and Petering, D.H. Intracellular DNA strand scission and growth inhibition of Ehrlich ascites tumor cells by bleomycins. Cancer Res., 50: 5275-5286, 1990.
3. Sikic, B.I. Biochemical and cellular determinants of bleomycin cytotoxicity. Cancer Surv., 5: 81-91, 1986.
4. Lin, R.S., Kwock, L., Hefter, K., and Misslbeck, G. Effects of iron, cooper, cobalt and their chelators on the cytotoxicity of bleomycin. Cancer Res., 43: 1049-1053, 1983.
5. Lyman, S., Ujjani, B., Renner, K., Antholine, W., Petering, D.H., Whetstone, J.W., and Knight, J.M. Properties of the initial reaction of bleomycin and several of its metal complexes with Ehrlich cells. Cancer Res., 46: 4472-4478, 1986.
6. Poddevin, B., Belehradek, J., Jr., and Mir, L.M. Stable [57Co]-bleomycin complex with a very high specific radioactivity for use at very low concentrations. Biochem. Biophys. Res. Commun., 173: 259-264, 1990.
7. Crooke, S.T. The molecular pharmacology of bleomycin. In: Crooke, S.T. and Prestayko, A.W. (eds.), Cancer and Chemotherapy, III, pp. 221-232. New York: Academic Press, Inc., 1981.
8. Orlowski, S., Belehradek, J., Jr., Paoletti, C., and Mir, L.M. Transient electropermeabilization of cells in culture. Increase of the cytotoxicity of anticancer drugs. Biochem. Pharmacol., 37: 4727-4733, 1988.
9. Poddevin, B., Orlowski, S., Belehradek, J., Jr., and Mir, L.M. Very high cytotoxicity of bleomycin introduced into the cytosol of cells in culture. Biochem. Pharmacol., 42(S): 67-75, 1991.
10. Mir, L.M., Orlowski, S., Belehradek, J., Jr., and Paoletti, C. Electrochemotherapy: potentiation of antitumour effect of bleomycin by local electric pulses. Eur. J. Cancer, 27: 68-72, 1991.
11. Belehradek, J., Jr., Orlowski, S., Poddevin, B., Paoletti, C., and Mir, L.M. Electrochemotherapy of spontaneous mammary tumours in mice. Eur. J. Cancer, 27: 73-76, 1991.
12. Mir, L.M., Belehradek, M., Domenge, C., Orlowski, S., Poddevin, B., Belehradek, J., Jr., Schwaab, G., Luboinski, B., and Paoletti, C. L'61ectrochimiotherapie, un nouveau traitcment antitumoral: premier essai clinique. Electrochemotherapy, a novel antitumor treatment: first clinical trial. C.R. Acad. Sci. (Paris) Ser. Ill, 313: 613-618, 1991.
13. Orlowski, S., and Mir, L.M. Cell electropermeabilization: a new tool for biochemical and pharmacological studies. Biochim. Biophys. Acta, 1154: 51-63, 1993.
14. Wyllie, A.H., Kerr, J.F.R., and Currie, A.R. Cell death: the significance of apoptosis. Int. Rev. Cytol., 68: 251-356, 1980.
15. Cohen, J.J., and Duke, R.C. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J. Immunol., 132: 38-42, 1984.
16. McConkey, D.J., Hartzell, P., Duddy, S.K., Hakansson, H., and Orrenius, S. 1, 2,7, 8 Tetrachlorodibenso-p-dioxin kills immature thymocytes by Ca2+-mediated endonuclease activation. Science (Washington DC), 242: 256-259, 1988.
17. McConkey, D.J., Nicotera, P., Hartzell, P., Bolloma, G., Wyllie, A.H., and Orrenius, S. Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration. Arch. Biochem. Biophys., 269: 365-370, 1989.
18. Perotti, M., Toddei, F., Mirabelli, F., Vairerti, M., Bellomo, G., McConkey, D.J., and Orrenius, S. Calcium-dependent DNA fragmentation in human synovial cells exposed to cold shock. FEBS Lett., 259: 331-334, 1990.
19. McConkey, D.J., Hartzell, P., Nicotera, P., and Orrenius, S. Calcium activated DNA fragmentation kills immature thymocytes. FASEB J., 3: 1843-1849, 1989.
20. Batistatou, A., and Greene, L.A. Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity. J. Cell Biol., 775: 461-471, 1991.
21. Giannakis, C., Forbes, I.J., and Zalewski, P.D. Ca2+/Mg2+-dependent nuclease: tissue distribution, relationship to inter-nucleosomal DNA fragmentation and inhibition by Zn2+. Biochem. Biophys. Res. Commun., 181: 915-920, 1991.
22. Wyllie, A.H., Morris, R.G., Smith, A.L., and Dunlop, D. Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis. J. Pathol., 142: 67-77, 1984.
23. Barry, M.A., and Eastman, A. Endonuclease activation during apoptosis: the role of cytosolic Ca2+ and pH. Biochem. Biophys. Res. Commun., 186: 782-789, 1992.
24. Chang, W.P., and Little, J.B. Delayed reproductive death in X-irradiated Chinese hamster ovary cells. Int. J. Radiat. Biol., 60: 483-496, 1991.
25. Radford, I.R. Mouse lymphoma cells that undergo interphase death show markedly increased sensitivity to radiation-induced DNA double-strand breakage as compared with cells that undergo mitotic death. Int. J. Radiat. Biol., 59: 1353-1369, 1991.
26. Waiters, R.L. Radiation-induced apoptosis in a murine T-cell hybridoma. Cancer Res., 52: 883-590, 1992.
27. Biedler, J.L., and Riehm, H. Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, on cytogenetic studies. Cancer Res., 30: 1171-1184, 1970.
28. Lazo, J.S., Schisselbauer, J.C., Meandzija, B., and Kennedy, K.A. Initial single-strand DNA damage and cellular pharmacokinetics of bleomycin A2. Biochem. Pharmacol., 38: 2207-2213, 1989.
29. Smith, C.A., Williams, G.T., Kingston, R., Jenkinson, E.J., and Owen, J.J.T. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature (Lond.), 337: 181-184, 1989.
30. Telford, W.G., King, L.E., and Fraker, P.J. Evaluation of glucocorticoid-induced DNA fragmentation in mouse thymocytes by flow cytometry. Cell Prolif., 24: 447-459, 1991.
31. Charcosset, J.Y., Bendirdjian, J.P., Lantieri, M.F., and Jacquemin-Sablon, A. Effects of 9-OH-ellipticine on cell survival, macromolecular syntheses and cell cycle progression in sensitive and resistant Chinese hamster lung cells. Cancer Res., 45: 4229-4236, 1985.
32. Kuo, M.T. Preferential damage of active chromatin by bleomycin. Cancer Res., 41: 2439-2443, 1981.
33. Sidik, K., and Smerdon, M.J. Bleomycin-induced DNA damage and repair in human cells permeabilized with lysophosphatidylcholine. Cancer Res., 50: 1613-1619, 1990.
34. Golstein, P., Ojcius, D.M., and Young, J.D.E. Cell death mechanisms and the immune system. Immunol. Rev., 727: 29-65, 1992.
35. Povirk, L.F., Wübker, W., Köhnlein, W., and Hutchinson, F. DNA double-strand breaks and alkali-labile bonds produced by bleomycin. Nucleic Acids Res., 4: 3573-3580, 1977.
36. Grimwade, J., and Beerman, T. Measurement of bleomycin, neocarzinostatin, and auromomycin cleavage of cell-free and intracellular simian virus 40 DNA and chromatin. Mol. Pharmacol., 30: 358-363, 1986.
37. Cullinan, E.B., Gawron, L.S., Rustum, Y M., and Beerman, T.A. Extrachromosomal chromatin: novel target for bleomycin cleavage in cells and solid tumors. Biochemistry, 30: 3055-3061, 1991.
38. Arends, M.J., Morris, R.G., and Wyllie, A.H. Apoptosis. The role of the endonuclease. Am. J. Pathol., 136: 593-608, 1990.
39. Krishan, A. Bleomycin-induced fine structural alterations in cultured mouse fibroblasts and human lymphocytes of neoplastic origin. Cancer Res., 33: 777-785, 1973.
40. Desai, L.S., Krishan, A., and Foley, G.E. Effects of bleomycin on cells in culture: a quantitative cytochemical study. Cancer (Phila.), 34: 1973-1977, 1974.
41. Daskal, Y., Crooke, S.T., Smetana, K., and Busch, H. Ultrastructural study of the effect of bleomycin A2 on the nucleolus and its possibly related cytoplasmic constituents in Novikoff hepatoma cells. Cancer Res., 35: 374-381, 1975.
42. Barranco, S.C., and Humphrey, R.M. The effects of bleomycin on survival and cell progression in Chinese hamster cells in vitro. Cancer Res., 57: 1218-1223, 1971.
43. Nagatsu, M., Richart, R.M., and Lambert, A. Effects of bleomycin on the cell cycle of Ehrlich ascites carcinoma. Cancer Res., 32: 1966-1970, 1972.
44. Tobey, R.A. Arrest of Chinese hamster cells in G2 following treatment with the anti-tumor drug bleomycin. J. Cell. Physiol., 79: 259-265, 1972.
45. Watanabe, M., Takabe, Y., Katsumata, T., and Terasima, T. Effects of bleomycin on progression through the cell cycle of mouse L-cells. Cancer Res., 34: 878-881, 1974.
46. Hittelman, W.N., and Rao, P.N. Bleomycin-induced damage in prematurely condensed chromosomes and its relationship to cell cycle progression in CHO cells. Cancer Res., 34: 3433-3439, 1974.
47. Ohama, K., and Kadotani, T. Cytologic effects of bleomycin on cultured human leukocytes. Jpn. J. Hum. Genet., 14: 293-297, 1970.
48. Bornstein, R.S., Hungerford, D.A., Haller, G., Engstrom, P.F., and Yarbo, J.W. Cytogenetic effects of bleomycin therapy in man. Cancer Res., 31: 2004-2007, 1971.
49. Paika, K.D., and Krishan, A. Bleomycin-induced chromosomal aberrations in cultured mammalian cells. Cancer Res., 33: 961-965, 1973.