Prophylactic Administration of Respiratory Syncytial Virus Immune Globulin to High-Risk Infants and Young Children

New England Journal of Medicine

Volumn 329, Issue 21, 1993, Pages 1524-1530

  Groothuis, Jessie R ^a   Simoes, Eric ^a   Levin, Myron J ^a   Hall, Caroline B ^b   Long, Christine E ^b   Rodriguez, William J ^c   Arrobio, Julita ^c   Meissner, H Cody ^d   Fulton, David R ^d   Welliver, Robert C ^e   Tristram, Debra A ^e   Siber, George R ^f   Prince, Gregory A ^g   Van Raden, Mark ^h   Hemming, Val G ⁱ  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

^c CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^d TUFTS UNIVERSITY   (United States)

^e UNIVERSITY AT BUFFALO   (United States)

^f Massachusetts Public Health Council   (United States)

^g Virion Systems Inc   (United States)

^h NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

ⁱ UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; RIBAVIRIN; VIRUS ANTIBODY;

ANTIBODY TITER; ARTICLE; CHILD; CLINICAL TRIAL; CONGENITAL HEART DISEASE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FEVER; HIGH RISK POPULATION; HOSPITALIZATION; HUMAN; HYPOXEMIA; IMMUNOPROPHYLAXIS; INFANT; INTRAVENOUS DRUG ADMINISTRATION; LOWER RESPIRATORY TRACT INFECTION; LUNG DYSPLASIA; MAJOR CLINICAL STUDY; MALE; OXYGEN SATURATION; PASSIVE IMMUNIZATION; PREMATURITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY DISTRESS; RESPIRATORY SYNCYTIAL PNEUMOVIRUS;

ANTIBODIES, VIRAL; BRONCHOPULMONARY DYSPLASIA; FEMALE; HEART DEFECTS, CONGENITAL; HUMAN; IMMUNIZATION, PASSIVE; IMMUNOGLOBULINS, INTRAVENOUS; INFANT; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; LOGISTIC MODELS; MALE; OPPORTUNISTIC INFECTIONS; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES; RISK FACTORS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027384670     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199311183292102     Document Type: Article

References (44)

1. Brandt CD, Kim HW, Arrobio JO, Epidemiology of respiratory syncytial virus infection in Washington, D.C. III. Composite analysis of eleven consecutive yearly epidemics. Am J Epidemiol 1973; 98: 355-364
2. Chanock RM, Parrott RH Acute respiratory disease in infancy and childhood: present understanding and prospects for prevention. Pediatrics 1965; 36: 21-39
3. Kim HW, Arrobio JO, Brandt CD, Epidemiology of respiratory syncytial virus infection in Washington, D.C. I. Importance of the virus in different respiratory tract disease syndromes and temporal distribution of infection. Am J Epidemiol 1973; 98: 216-225
4. Appendix N: prospects for immunizing against respiratory syncytial virus. In: New vaccine development: establishing priorities. Vol. I. Diseases of importance in the United States. Washington, D.C.: National Academic Press, 1985:397-410.
5. Parrott RH, Kim HW, Arrobio JO, Epidemiology of respiratory syncytial virus infection in Washington, D.C. II. Infection and disease with respect to age, immunologic status, race and sex. Am J Epidemiol 1973; 98: 289-300
6. Glezen WP, Paredes A, Allison JE, Taber LH, Frank AL Risk of respiratory syncytial virus infection for infants from low-income families in relationship to age, sex, ethnic group, and maternal antibody level. J Pediatr 1981; 98: 708-715
7. Loda FA, Clyde WA Jr, Glezen WP, Senior RJ, Sheaffer CI, Denny FW Jr Studies on the role of viruses, bacteria, and M. pneumoniae as causes of lower respiratory tract infections in children. J Pediatr 1968; 72: 161-176
8. Bruhn FW, Mokrohisky ST, McIntosh K Apnea associated with respiratory syncytial virus infection in young infants. J Pediatr 1977; 90: 382-386
9. McMillan JA, Tristram DA, Weiner LB, Higgins AP, Sandstrom C, Brandon R Prediction of the duration of hospitalization in patients with respiratory syncytial virus infection: use of clinical parameters. Pediatrics 1988; 81: 22-26
10. Green M, Brayer AF, Schenkman KA, Wald ER Duration of hospitalization in previously well infants with respiratory syncytial virus infection. Pediatr Infect Dis J 1989; 8: 601-605
11. Groothuis JR, Gutierrez KM, Lauer BA Respiratory syncytial virus infection in children with bronchopulmonary dysplasia. Pediatrics 1988; 82: 199-203
12. Abman SH, Ogle JW, Butler-Simon N, Rumack CM, Accurso FJ Role of respiratory syncytial virus in early hospitalizations for respiratory distress in young infants with cystic fibrosis. J Pediatr 1988; 113: 826-830
13. McIntosh K, Ellis EF, Hoffman LS, Lybass TG, Eller JJ, Fulginiti VA The association of viral and bacterial respiratory infections with exacerbations of wheezing in young asthmatic children. J Pediatr 1973; 82: 578-590
14. MacDonald NE, Hall CB, Suffin SC, Alexson C, Harris PJ, Manning JA Respiratory syncytial viral infection in infants with congenital heart disease. N Engl J Med 1982; 307: 397-400
15. Hall CB, Powell KR, MacDonald NE, Respiratory syncytial viral infection in children with compromised immune function. N Engl J Med 1986; 315: 77-81
16. Navas L, Wang E, de Carvalho V, Robinson J Improved outcome of respiratory syncytial virus infection in a high-risk hospitalized population of Canadian children: Pediatric Investigators Collaborative Network on Infections in Canada. J Pediatr 1992; 121: 348-354
17. Prince GA, Jenson AB, Horswood RL, Camargo E, Chanock RM The pathogenesis of respiratory syncytial virus infection in cotton rats. Am J Pathol 1978; 93: 771-791
18. Prince GA, Horswood RL, Camargo E, Koenig D, Chanock RM Mechanisms of immunity to respiratory syncytial virus in cotton rats. Infect Immun 1983; 42: 81-87
19. Prince GA, Jenson AB, Hemming VG, Enhancement of respiratory syncytial virus pulmonary pathology in cotton rats by prior intramuscular inoculation of formalin-inactivated virus. J Virol 1986; 57: 721-728 [Erratum, J Virol 1986;59:193.]
20. Prince GA, Horswood RL, Chanock RM Quantitative aspects of passive immunity to respiratory syncytial virus infection in infant cotton rats. J Virol 1985; 55: 517-520
21. Prince GA, Hemming VG, Horswood RL, Chanock RM Immunoprophylaxis and immunotherapy of respiratory syncytial virus infection in the cotton rat. Virus Res 1985; 3: 193-206
22. Prince GA, Hemming VG, Horswood RL, Baron PA, Chanock RM Effectiveness of topically administered neutralizing antibodies in experimental immunotherapy of respiratory syncytial virus infection in cotton rats. J Virol 1987; 61: 1851-1854
23. Bruhn FW, Yeager AS Respiratory syncytial virus in early infancy: circulating antibody and the severity of infection. Am J Dis Child 1977; 131: 145-148
24. Lamprecht CL, Krause HE, Mufson MA Role of maternal antibody in pneumonia and bronchiolitis due to respiratory syncytial virus. J Infect Dis 1976; 134: 211-217
25. Ogilvie MM, Vathenen AS, Radford M, Codd J, Key S Maternal antibody and respiratory syncytial virus infection in infancy. J Med Virol 1981; 7: 263-271
26. Ward KA, Lambden PR, Ogilvie MM, Watt PJ Antibodies to respiratory syncytial virus polypeptides and their significance in human infection. J Gen Virol 1983; 64: 1867-1876
27. Groothuis JR, Levin MJ, Rodriguez W, Use of intravenous gamma globulin to passively immunize high-risk children against respiratory syncytial virus: safety and pharmacokinetics: the RSVIG Study Group. Antimicrob Agents Chemother 1991; 35: 1469-1473
28. Siber GR, Leszczynski J, Pena-Cruz V, Protective activity of a human respiratory syncytial virus immune globulin prepared from donors screened by microneutralization assay. J Infect Dis 1992; 165: 456-463
29. Groothuis JR, Woodin KA, Katz R, Early ribavirin treatment of respiratory syncytial viral infection in high-risk children. J Pediatr 1990; 117: 792-798
30. Lauer BA, Masters HA, Wren CG, Levin MJ Rapid detection of respiratory syncytial virus in nasopharyngeal secretions by enzyme-linked immunosorbent assay. J Clin Microbiol 1985; 22: 782-785
31. Welliver RC Detection, pathogenesis, and therapy of respiratory syncytial virus infections. Clin Microbiol Rev 1988; 1: 27-39
32. Groothuis JR, Salbenblatt CK, Lauer BA Severe respiratory syncytial virus infection in older children. Am J Dis Child 1990; 144: 346-348
33. Henderson FW, Collier AM, Clyde WA Jr, Denny FW Respiratory-syncytial-virus infections, reinfections and immunity: a prospective, longitudinal study in young children. N Engl J Med 1979; 300: 530-534
34. Simoes EAF, Groothuis JR, Levin MJ, Standard (IGIV) vs RSV enriched (RSVIG) intravenous immune globulin for RSV immunoprophylaxis. Pediatr Res 1993; 33: 183A-183A abstract.
35. de Sierra TM, Kumar ML, Wasser TE, Murphy BR, Subbarao EK Respiratory syncytial virus-specific immunoglobulins in preterm infants. J Pediatr 1993; 122: 787-791
36. Simoes EAF, King SJ, Lehr MV, Groothuis JR Preterm twins and triplets: a high-risk group for severe respiratory syncytial virus infection. Am J Dis Child 1993; 147: 303-306
37. Hall CB, Kopelman AE, Douglas RG Jr, Geiman JM, Meagher MP Neonatal respiratory syncytial virus infection. N Engl J Med 1979; 300: 393-396
38. Baker CJ, Melish ME, Hall RT, Intravenous immune globulin for the prevention of nosocomial infection in low-birth-weight neonates. N Engl J Med 1992; 327: 213-219
39. Weisman LE, Stoll BJ, Kueser TJ, Intravenous immune globulin therapy for early-onset sepsis in premature neonates. J Pediatr 1992; 121: 434-443
40. Newburger JW, Takahashi M, Burns JC, The treatment of Kawasaki syndrome with intravenous gamma globulin. N Engl J Med 1986; 315: 341-347
41. Suffin SC, Prince GA, Muck KB, Porter DD Immunoprophylaxis of respiratory syncytial virus infection in the infant ferret. J Immunol 1979; 123: 10-14
42. Taylor G, Stott EJ, Bew M, Fernie BF, Cote PJ Monoclonal antibodies protect against respiratory syncytial virus. Lancet 1983; 2: 976-976
43. Murphy BR, Sotnikov AV, Lawrence LA, Banks SM, Prince GA Enhanced pulmonary histopathology is observed in cotton rats immunized with formalin-inactivated respiratory syncytial virus (RSV) or purified F glycoprotein and challenged with RSV 3-6 months after immunization. Vaccine 1990; 8: 497-502
44. Connors M, Collins PL, Firestone CY, Cotton rats previously immunized with a chimeric RSV FG glycoprotein develop enhanced pulmonary pathology when infected with RSV, a phenomenon not encountered following immunization with vaccinia-RSV recombinants or RSV. Vaccine 1992; 10: 475-484