Preparation of Substituted N-Phenyl-4-aryl-2-pyrimidinamines as Mediator Release Inhibitors

Journal of Medicinal Chemistry

Volumn 36, Issue 19, 1993, Pages 2716-2725

  Paul, Rolf ^a   Hallett, William A ^a   Hanifin, John W ^a   Reich, Marvin F ^a   Johnson, Bernard D ^a   Lenhard, Robert H ^a   Dusza, John P ^a   Kerwar, Suresh S ^a   Lin, Yang i ^a   Pickett, Walter C ^a   Seifert, Christina M ^a   Torley, Lawrence W ^a   Tarrant, M Ernestine ^a   Wrenn, Simeon ^a  

^a WYETH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIASTHMATIC AGENT; N [3 (1H IMIDAZOL 1 YL)PHENYL] 4 (2 PYRIDINYL) 2 PYRIMIDINAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTHMA; BASOPHIL; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; MALE; MAST CELL; MOUSE; NONHUMAN; PASSIVE SKIN ANAPHYLAXIS; PRIORITY JOURNAL; RAT; RHESUS MONKEY; STRUCTURE ACTIVITY RELATION;

ANIMAL; BASOPHILS; FEMALE; HISTAMINE ANTAGONISTS; HUMAN; IMIDAZOLES; LETHAL DOSE 50; MACACA MULATTA; MALE; MICE; PASSIVE CUTANEOUS ANAPHYLAXIS; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0027383448     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00071a002     Document Type: Article

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