Immunological findings in growth hormone-treated patients

Hormone Research in Paediatrics

Volumn 39, Issue 3-4, 1993, Pages 107-110

  Wit, J M ^a   Kooijman, R ^a   Rijkers, G T ^a   Zegers, B J M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Growth; Growth hormone treatment; Immune function; Lymphocytes

Indexed keywords

GROWTH HORMONE;

ADULT; ANIMAL EXPERIMENT; CHILD; GROWTH DISORDER; GROWTH HORMONE DEFICIENCY; HORMONAL THERAPY; HUMAN; HUMAN CELL; IMMUNE SYSTEM; IMMUNOLOGY; LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; THYMUS;

ANIMAL; GROWTH HORMONE; HUMAN; IMMUNITY; IMMUNOLOGIC DISEASES;

EID: 0027383337     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000182708     Document Type: Article

References (70)

1. Bascdovsky H. Sorkin E: Network of immune-ncuroendocrine interactions. Clin Exp Immunol 1977:27:1-5.
2. Goldstein EJ, Fritzlcr MJ: The role of thymus-hypothalamus-pituitary-gonadal axis in normal immune processes and autoimmunity. J Rheumatol 1987:14:982-987.
3. Kordon C, Bihorcau C: Integrated communication between the nervous endocrine and immune systems. Horm Res 1989:31:100-104.
4. Bascdovsky H, Del Rcy AE, Sorkin E: lmmu-no-endocrine interactions. J Immunol 1985; 135:750-754.
5. Blalock JE, Bost KC, Smith EM: Neuroendocrine peptide hormones and their receptors in the immune system: Production, processing and action. J Ncuroimmunol 1985:10:31-40.
6. Pert CB, RulT MR, Wcher RJ, Herkenham M: Neuropeptides and their receptors. A psychosomatic network. J Immunol 1985:135:820-826.
7. Bozzola M. Valtorta A. Moretla A. Schimpff RM: GH. GHRH and the immune system. Growth Growth Factors Curr Med Lit 1991;6: 135-139.
8. Kclley KW: Growth hormone, lymphocytes and macrophages. Biochcm Pharmacol 1989: 38:705-713.
9. Arrenbrecht S: Specific binding of growth hormone to thymocytes. Nature 1974:252:255-257.
10. Eshct R. Manheimer S. Chobsieng P. Laron Z: Human growth hormone receptors in human circulating lymphocytes. Horm Metab Res 1975:7:352-353.
11. Kiess W. Butenandt O: Specific growth hormone receptors on human peripheral mononuclear cells: Expression, identification and characterization. J Clin Endocrinol Metab 1985:60: 740-746.
12. Kiess W, Holtmann H, Butenandt O, Eife R: Modulation of lymphoproliferation by human growth hormone. Eur J Pediatr 1983:140:47-50.
13. Vanderschuercn-Lodeweyckx U, Staf B, Van der Bcrghc H, Eggermont E, Eeckels R: Growth hormone and lymphocyte transformation. Lancet 1973;1:44L
14. Bozzola M, Valtorta A, Moretta A, Montagna D, Maccario R, Burgio GR: Modulating effect of growth hormone (GH) on PHA-induced lymphocyte proliferation. Thymus 1988,12: 157-165.
15. Kooijman R, Willems M, Rijkers GT, Brink-man ASC, Van Buul-Offcrs SJ, Hcijnen CJ, Zegers GJM: Effects of insulin-like growth factors and growth hormone on the in vitro proliferation of T lymphocytes. J Ncuroimmunol 1992:38:95-104.
16. Snow EC. Fcldbush TL. Oaks J A: The effect of growth hormone and insulin upon MLC responses and the generation of cytotoxic lymphocytes. J Immunol 1981:126:161-164.
17. Mcrchaw S, Tatarsky J, Hochbcrg Z: Enhancement of human granulopoiesis in vitro by bio-synthetic insulin-like growth factor 1/soma-tomedin C and human growth hormone. J Clin Invest 1988:81:791-797.
18. Fu YK, Arkins S, Shang Wang B, Kellcy KW: A novel role of growth hormone and insulin-like growth factor-1. Priming neutrophils for superoxide anion secretion. J Immunol 1991:146: 1602-1608.
19. Wicdermann CJ, Niedermuhlbiehlcr M, Bcim-pold H, Braunsteiner H: In vitro activation of neutrophils of the aged by recombinant human growth hormone. J Infect Dis 1991:164:1017-1020.
20. Wicdermann CJ. Niedermuhlbiehlcr M, Geissler D. Bcimpold H, Braunsteiner H: Priming of normal human neutrophils by recombinant human growth hormone. Br J Haematol 1991:78:19-22.
21. Goldc DW, Bersch N, Li CH: Growth hormone: Species specific stimulation of crythro-poiesis in vitro. Science 1977:196:1112-1113.
22. Li S, Crenshaw EB III. Rawson EJ. Simmons DM. Swanson LW, Rosenfcld MG: Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-J Nature 1990;347:528-533.
23. Van Buul-Offers SC. Van den Brande JL, Du-moleijn L, Korteland-van Male AM, Van dc Klundcrt P: The Snell-dwarfmousc II. Acta Endocrinol 1978:89:646-658.
24. Baroni CD, Fabris N, Bertoli G: Effects of hormones on development and function of lymphoid tissues. Synergistic action of thyroxin and somatotropic hormone in pituitary dwarf mice. J Immunol 1969:17:303-314.
25. Pierpaoli W. Baroni C. Fabris N. Sorkin E: Hormones and immunological capacity. II. Re-constitution of antibody production in hor-monally deficient mice by somatotropic hormone, thyrotropic hormone and thyroxin. J Immunof 1969:16:217-230.
26. Smith PE: Effect of hypophyseclomy upon the involution of the thymus in the rats. Anat Rec 1930:47:119-123.
27. Herberman RB. Holden HT: Natural cell-mediated immunity. Adv Cancer Res 1978:27: 305-308.
28. Davila DR, Brief S, Simon J, Hammer RE, Brinstcr RL, Kellcy KW: Role of growth hormone in regulating T-dcpcndcnt immune events in aged. nude, and transgenic rodents. J Neuro Sci Res 1987;18:108-116.
29. Saxena GB, Saxena RK, Adler WH: Regulation of natural killer activity in vivo. III. Effect of hypophysectomy and growth hormone treatment on the natural killer activity of the mouse spleen cell population. Int Arch Allergy Appl Immunol 1982:67:169-174.
30. Nagy E. Berczi I. Fricscn HG: Regulation of immunity in rats by lactogenic and growth hormones. Acta Endocrinol 1983:102:351-357.
31. Berczi I. Nagy E. de Toledo SM. Matusik RJ. Fricsen HG: Pituitary hormones regulate c-myc and DNA synthesis in lymphoid tissue. J Immunol 1991:146:2201-2206.
32. Edwards CK III, Yunger LM, Lorcnce RM, Dantzcr R, Kellcy KW: The pituitary gland is required for protection against lethal effects of Salmonella lyphimurium. Proc Natl Acad Sci USA 1991:88:2274-2277.
33. Abassi V, Bellanti JA: Humoral and cell-mediated immunity in growth hormone-deficient children: Effect of therapy with human growth hormone. Pediatr Res 1985:19:299-301.
34. Rapaport R, Olcske J, Ahdich H. Salomon S. Belfaus C. Denny T: Suppression of immune function in growth hormone deficient children during treatment with human growth hormone. J Pediatr 1986:109:434-439.
35. Bozzola MM, Maccario R, Cisternino M, De Amici M, Valtorta A, Moretta A, Biscaldi F, Schimpff RM: Immunological and endocrinological response to growth hormone therapy in short children. Acta Paediatr Scand 1988:77: 675-680.
36. Petersen BH. Rapaport R. Henry DP, Husc-man C, Moore WV: Effect of treatment with biosynthctic growth hormone on peripheral blood lymphocytes populations and function in growth hormone deficient children. J Clin Endocrinol Metab 1990:70:1756-1760.
37. Spadoni GL, Rossi P, Ragno W. Galli E, Cian-farni S. Galasso C. Boschcrini B: Immune function in growth hormone-deficient children treated with biosynthetic growth hormone. Acta Paediatr Scand 1991:80:75-79.
38. Fleishcr TA. White RM. Broder S, Nissley PS. Blaesc RM. Mulvihill JJ. Olive G, Waldmann TA: X-linked hypogammaglobulinaemia and isolated growth hormone deficiency. N Engl J Med 1980:302:1429-1434.
39. Casanova S. Repellin AM. Schimpff RM: Production of interleukin-la and interlcukin-2 by mononuclear cells from children with growth delay in relation to the degree of growth hormone deficiency: Effects of substitutive treatment. Horm Res 1990:34:209-214.
40. Kiess W, Doerr H, Butenandt O, Bclohradsky MD: Lymphocyte subsets and natural-killer activity in growth hormone deficiency. N Engl J Med 1986:314:321.
41. Kiess W. Malozowski S. Gclato M. Butenand O, Doerr H, Crisp B. Eisl E, Maliush A, Bclohradsky BH: Lymphocyte subset distribution and natural killer activity in growth hormone deficiency before and during short-term treatment with growth hormone releasing hormone. Clin Immunol Immunopathol 1988:48:85-94.
42. Bozzola M. Valtorta A. Moretta A. Cisternino M. Biscaldi I. Schimpff RM: In vitro and in vivo effect of growth hormone on cytotoxic activity. J Pediatr 1990:117:596-599.
43. Mocchcgiani E, Paolucci P, Balsamo A, Cac-ciari E, Fabris N: Influence of growth hormone on thymic endocrine activity in humans. Horm Res 1990:33:248-255.
44. Gupta D. Fikrig SM. Noval MS: Immunological studies in patients with isolated growth hormone deficiency. Clin Exp Immunol 1983:54: 87-90.
45. Etz-ioni A. Pollack S. Hochbcrg Z: Immune function in growth hormone deficient children treated with biosynthetic growth hormone. Acta Paedialr Scand 1988:77:169-170.
46. Church JA, Costin G, Brooks J: Immune functions in children treated with biosynthetic growth hormone. J Pediatr 1989:115:420-423.
47. Bozzola MM. Cistcrnino M. Valtorta A. Mo-rctta A. Biscaldi I. Maghnic M. De Amici M. SchimplTRM: Effect ofbiosynthetic methionyl growth hormone therapy on the immune function in GH deficient children. Horm Res 1989: 31:153-156.
48. Wit JM, van Es A, Hindmarsh PC, Kamp GA, Brook DGD, Preece JM, Metthews DR, Mas-sarono AA: Growth hormone (GH) secretion in patients with Turner’s syndrome as determined by time scries analysis. Acta Endocrinol 1992:127:7-12.
49. Veldhuis JD, Sotos JF, Sherman BM: Genen-tcch Collaborative Group: Decreased metabolic clearance of endogenous growth hormone and specific alterations in the pulsatile mode of growth hormone secretion occur in prepubertal girls with Turner’s syndrome. J Clin Endocrinol Mctab 1991:73:1073-1080.
50. Williams ED, Engel E, Forbes AP: Thyroiditis and gonadal dysgenesis. N Engl J Med 1964; 270:805.
51. Engel E. Forbes AP: Cytogenetic and clinical findings in 48 patients with congenitally defective or absent ovaries. Medicine 1965:44:135.
52. Fleming S, Cowcll C. Bailey J, Burrow GN: Hashimoto’s disease in Turner’s syndrome. Clin Invest Med 1988:114:243-246.
53. Pai GS, Leach DC, Weiss L, Wolf C, Van Dyke DL: Thyroid abnormalities in 20 children with Turner syndrome. J Pediatr 1977:91:267-269.
54. Grunciro de Papcndicck L, lorcansky S, Coco R, Rivarola MA, Bergada C: High incidence of thyroid disturbances in 49 children with Turner syndrome. J Pediatr 1987:111:258-261.
55. Bright GM. Robert M. Blizzard RD. Kaiser DL. Clark WL: Organ-specific autoantibodies in children with common endocrine diseases. J Pediatr 1982:1001:8-14.
56. Nicnhuis HE, Rongcn-Westcrlakcn C, Gccrtz-cn HGM, Rijkers GT, Zcgcrs BJM, Wit JM: Long term effect of human growth hormone therapy on the prevalence of auto-antibodies in Turner’s syndrome. Hormone Res 1993:39 (suppl):49-53.
57. Jensen K, Petersen PH, Nielsen EL, Dahl G, Nielsen J: Scrum immunoglobulin M. G and A concentration levels in Turner’s syndrome compared with normal women and men. Hum Genet 1976:31:329-334.
58. Cacciari E, Masi M. Fantini MP. Licastro F. Cicognani A. Pirazzoli P. Villa MP. Specchia F. Forabosco A, Franccschi C. Manon L: Scrum immunoglobulins and lymphocyte sub-populations derangement in Turner’s syndrome. J Immunogcnet 1981:8:337-344.
59. Lorini R, Ugazio AG. Cammarcri V. Larizza D, Castcllazzi AM. Brugo MA. Scvcri F: Immunoglobulin levels. T-cell markers, mitogen responsiveness and thymic hormone activity in Turner’s syndrome. Thymus 1983;5:61-66.
60. Rongen-Westerlakcn C, Rijkers GT. Scholtens EJ, Van Es A, Wit JM. Van den Brandc JL. Zegcrs BJM: Immune function in girls with Turner Syndrome before and during treatment with growth hormone. J Pediatr 1991:119:268-272.
61. Pfaffle RW, DiMattia GE. Parks JS. Brown MR. Wit JM. Janscn M, Van dcr Nat H. Van den Brande JL. Rosenfeld MG, Ingraham HA: Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia. Science 1992:257:1118-1121.
62. Wit JM. Draycr NM. Jansen M. Walenkamp MJ. Hackeng WHL. Tysscn JHH. Van den Brandc JL: Total deficiency of growth hormone and prolactin, and partial deficiency of thyroid stimulating hormone in two Dutch families: A new variant of hereditary pituitary deficiency. Hormone Res 1989:32:170-177.
63. Weigent DA, Baxter JB, Wear WE, Smith LR, Bost KL, Blalock JE: Production of immunorc-active growth hormone by mononuclear leukocytes. FASEB J 1988:2:2812-2818.
64. Weigent DA. Blalock JE: The production of growth hormone by subpopulat ions of rat mononuclear leukocytes. Cell Immunol 1991:135: 55-65.
65. Hicstand PC, Meklcr P. Nordmann R. Gricdcr A, Pcrmmongkol C: Prolactin as a modulator of lymphocyte responsiveness provides a possible mechanism of action for cyclosporine. Proc Natl Acad Sci USA 1986;86:2599-2603.
66. Sabharwal P, Glaser R. Lafuse W, Varma S. Liu Q, Arkins S. Kooijman R. Kutz L: Prolactin synthesized and secreted by human peripheral blood mononuclear cells: An autocrine growth factor for lymphoprolifcration. Proc Natl Acad Sci USA 1992;89:7713-7716.
67. Weigent DA, Blalock JE, LeBoeuf RD: An anti-sense oligodeoxynuclcotide to growth hormone messenger ribonucleic acid inhibits lymphocyte proliferation. J Endocrinol 1991:128: 2053-2057.
68. Baxter JB. Blalock JE. Weigent DA: Characterization of immunoreactivc insulin-like growth factor-1 from leukocytes and its regulation by growth hormone. J Endocrinol 1991:129: 1727-1733.
69. Kirstcin M, Aston C, Hintz R, Vlassara H: Receptor-specific induction of insulin-like growth factor-1 in human monocytes by advanced glycosylation end product-modified proteins. J Clin Invest 1992:90:439-446.
70. Kooijman R. Willcms M. De Haas CJC, et al: Expression of type 1 insulin-like growth factor receptors on human peripheral blood mononuclear cells. Endocrinology 1992:131:2244-2250.