Development of biodegradable microspheres and nanospheres for the controlled release of cyclosporin A

International Journal of Pharmaceutics

Volumn 99, Issue 2-3, 1993, Pages 263-273

  Sánchez, Alejandro ^a   Vila Jato, JoséL ^a   Alonso, María J ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Controlled release; Cyclosporin A; Immunosuppressive agent; Microsphere; Nanosphere; Peptide delivery system; Poly(dl lactide co glycolide)

Indexed keywords

CYCLOSPORIN A; MICROSPHERE; POLYGLACTIN; POLYMER;

ARTICLE; DRUG DEGRADATION; DRUG RELEASE; GEL PERMEATION CHROMATOGRAPHY; INFRARED SPECTROPHOTOMETRY; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; THERMAL ANALYSIS; X RAY DIFFRACTION;

EID: 0027383302     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(93)90369-Q     Document Type: Article

References (27)

1. HPLC of proteins and peptides in the pharmaceutical industry
2. Les technologies d'embolisation selective, l'utilisation des microspheres
3. Cyclosporine as a new approach to therapy of autoimmune diseases
4. The formation and characterization of hydrocortisone-loaded poly(dl-lactide) microspheres
5. Formulation of dosage forms
6. Formulation concerns of protein drugs
7. Controlled release of cyclosporine from microspheres
8. Controlled vaccine release in the gut-associated lymphoid tissues: I. Orally administered biodegradable microspheres target the Peyer's patches
9. Preparation of poly(l-lactide) microspheres of different crystalline morphology and effect of crystalline morphology on drug release rate
10. The uptake and translocation of latex nanospheres and microspheres after oral administration to rats
11. Nanoparticle uptake by the rat gastrointestinal mucosa: Quantitation and particle size dependency
12. Preparation of poly(dl-lactide/glycolide) nanoparticles of controlled particle size distribution: Application of experimental designs
13. Pharmacokinetics of cyclosporine in human renal transplantation
14. Effects of cyclosporine on the isolated perfused rat kidney
15. Dialysis and renal transplant therapy
16. Prolonged delivery of peptides by microcapsules
17. Sandimmun(e) (cyclosporin) in autoimmune diseases. A selection of publications
18. Approaches to the analysis of peptides
19. Controlled delivery systems for peptides
20. Controlled release of leutinizing hormone releasing hormone analogue from poly(d,l-lactide-col-glycolide) microspheres
21. Liquid-chromatographic determination of cyclosorin A in blood and plasma
22. Clinical use and future of parenteral microsphere delivery systems
23. Pharmacokinetics of two alternative dosage forms for cyclosporine: liposomes and intralipid
24. Tissue response to biodegradable injectable microcapsules
25. Lactid/glycolic acid polymers
26. Pharmacologic aspects of cyclosporine therapy: Pharmacokinetics
27. Selective transfer of cyclosporin to thoracic lymphatic systems by the application of lipid microspheres