Polyketide synthesis: Prospects for hybrid antibiotics

Annual Review of Microbiology

Volumn 47, Issue , 1993, Pages 875-912

  Katz, Leonard ^a   Donadio, Stefano ^a,b  

^a ABBOTT LABORATORIES   (United States)

^b Gruppo Lepetit SpA   (Italy)

Author keywords

biosynthesis; fatty acid synthesis; multienzyme complex; multifunctional enzyme; Streptomyces spp.

Indexed keywords

ACLARUBICIN; ACTINORHODINE; ANTHRACYCLINE DERIVATIVE; ANTIBIOTIC AGENT; ASPYRONE; DAUNORUBICIN; DIHYDROCURVALIN; DIHYDROGRANATICIN; DOXORUBICIN; ERYTHROMYCIN; KALAFUNGIN; METHYMYCIN; NANAOMYCIN D; NONACTIN; OXYTETRACYCLINE; POLYKETIDE; TETRACENOMYCIN C; TYLOSIN; UNCLASSIFIED DRUG;

BIOSYNTHESIS; FATTY ACID SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; STREPTOMYCES;

STREPTOMYCES;

EID: 0027382486     PISSN: 00664227     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.mi.47.100193.004303     Document Type: Review

References (5)

1. Adamitis, T., Champness, W. 1992. Genetic analysis of absB, a Streptomyces coelicolor locus involved in global antibiotic regulation. J. Bacteriol. 174:4622-38
2. Adamitis, T., Riggle, P., Champness, W. 1992. Mutations in a new Streptomyces coelicolor locus which globally block antibiotic synthesis but not sporulation. J. Bacteriol. 172:2962-69
3. Amy, C. M., Witkowski, A., Naggert, J., Williams, B., Randhawa, Z., Smith, S. 1989. Molecular cloning and sequencing of cDNAs encoding the entire rat fatty acid synthase. Proc. Natl. Acad. Sci. USA 86:3114-18
4. Andersen, J. F., Tatsuta, K., Gunji, H., Ishiyama, T., Hutchinson, C. R. 1992. Substrate specificity of 6-deoxyerythronolide B hydroxylase, a soluble bacterial cytochrome P450. Biochemistry 32:1905-13
5. Donadio, S., McAlpine, J. B., Sheldon, P. J., Jackson, M., Katz, L. 1993. An erythromycin analog produced by reprogramming of polyketide synthesis. Proc. Natl. Acad. Sci. USA 90:In press