Augmentation of synthesis of plasminogen activator inhibitor type-1 in arterial endothelial cells by glucose and its implications for local fibrinolysis

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 13, Issue 12, 1993, Pages 1822-1828

  Nordt, Thomas K ^a   Klassen, Kevin J ^a   Schneider, David J ^a   Sobel, Burton E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Atherogenesis; Atherosclerosis; Cardiovascular disease; Fibrinolysis; Hyperglycemia; Non insulin dependent diabetes mellitus; Type II diabetes

Indexed keywords

GLUCOSE; INSULIN; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; SORBITOL;

ANIMAL CELL; ARTERY ENDOTHELIUM; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; ENDOTHELIUM CELL; FIBRINOLYSIS; HUMAN; HUMAN CELL; HYPERGLYCEMIA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; SWINE;

ANIMAL; AORTA; CULTURE MEDIA, CONDITIONED; DNA; ENDOTHELIUM, VASCULAR; FIBRINOLYSIS; GLUCOSE; HUMAN; LIVER; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEINS; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; SWINE; TUMOR CELLS, CULTURED;

EID: 0027381925     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.13.12.1822     Document Type: Article

References (28)

1. Pan WH, Cedres LB, Liu K, Dyer A, Schoenberger JA, Shekelle RB, Stamler R, Smith D, Collette P, Stamler J. Relationship of clinical diabetes and asymptomatic hyperglycemia to risk of coronary heart disease mortality in men and women. Am J Epidemiol. 1986;123:504-516.
2. Auwerx J, Bouillon R, Collen D, Geboers J. Tissue-type plasminogen activator antigen and plasminogen activator inhibitor in diabetes mellitus. Arteriosclerosis. 1988;8:68-72.
3. Juhan-Vague I, Alessi MC, Vague P. Increased plasma plasminogen activator inhibitor 1 levels: a possible link between insulin resistance and atherothrombosis. Diabelologia. 1991;34:457-462.
4. Alessi MC, Juhan-Vague I, Kooistra T, Declerck PJ, Collen D. Insulin stimulates the synthesis of plasminogen activator inhibitor 1 by the human hepatocellular cell line Hep G2. Thromb Haemost. 1988;60:491-494.
5. Schneider DJ, Sobel BE. Augmentation of synthesis of plasminogen activator inhibitor type 1 by insulin and insulin-like growth factor type 1: implications for vascular disease in hyperinsulinemic states. Proc Natl Acad Sci USA. 1991;88:9959-9963.
6. Sobel BE, Hirsh J. Principles and practice of coronary thrombolysis and conjunctive treatment. Am J Cardiol. 1991;68:382-388. Editorial.
7. Eisenberg PR, Miletich JP, Sobel BE. Factors responsible for differential procoagulant effects of diverse plasminogen activators in plasma. Fibrinofysis. 1991;5:217-224.
8. Jawien A, Bowen-Pope DF, Lindner V, Schwanz SM, Clowes AW. Platelet-derived growth factor promotes smooth muscle migration and intimai thickening in a rat model of balloon angioplasty. J Clin Invest. 1992;89:507-511.
9. Deuel TF, Senior RM, Huang JS, Griffin GL. Chemotaxis of monocytes and neutrophils to platelet-derived growth factor. J Clin Invest. 1982;69:1046-1049.
10. Schwartz CJ, Valente AJ, Kelley JL, Sprague EA, Edwards EH. Thrombosis and the development of atherosclerosis: Rokitansky revisited. Semin Thromb Hemost. 1988;14:189-195.
11. van Wersch JWJ, Westerhuis LWJJM, Venekamp WJRR. Glycometabolic control and fibrinolysis in diabetic patients. Haemostasis. 1990;20:241-250.
12. Landin K, Stigendal L, Eriksson E, Krotkiewski M, Risberg B, Tengborn L, Smith U. Abdominal obesity is associated with an impaired fibrinolytic activity and elevated plasminogen activator inhibitor-1. Metabolism. 1990;39:1044-1048.
13. Butler WJ, Ostrander LD, Carman WJ, Lamphiear DE. Mortality from coronary heart disease in the Tecumseh study. Am J Epidemiol. 1985;121:541-547.
14. Barrett-Connor E, Wingard DL, Criqui MH, Suarez L. Is borderline fasting hyperglycemia a risk factor for cardiovascular death? J Chronic Dis. 1984;37:773-779.
15. Donahue RP, Abbott RD, Reed DM, Yano K. Postchallenge glucose concentration and coronary heart disease in men of Japanese ancestry: Honolulu Heart Program. Diabetes. 1987;36: 689-692.
16. lc with prevalent cardiovascular disease in the original cohort of the Framingham heart study. Diabetes. 1992;41: 202-208.
17. van Hinsbergh VWM, Binnema D, Scheffer MA, Sprengers ED, Kooistra T, Rijken DC. Production of plasminogen activators and inhibitor by serially propagated endothelial cells from adult human blood vessels. Arteriosclerosis. 1987;7:389-400.
18. Chmielewska J, Wiman B. Determination of tissue plasminogen activator and its "fast" inhibitor in plasma. Clin Chem. 1986;32: 482-485.
19. Lucore CL, Sobel BE. Interactions of tissue-type plasminogen activator with plasma inhibitors and their pharmacologic implications. Circulation. 1988;77:660-669.
20. Misbin RI, Merimee TJ, Lowenstein JM. Insulin removal by isolated perfused rat liver. Am J Physiol 1976;230:171-177.
21. Nordt TK, Schneider DJ, Sobel BE. Augmentation of the synthesis of plasminogen activator inhibitor type-1 (PAI-1) by precursors of insulin: a potential risk factor for vascular disease. Circulation. In press.
22. Kaiser N, Sasson S, Feener EP, Boukobza-Vardi N, Higashi S, Moller DE, Davidheiser S, Przybylski RJ, King GL. Differential regulation of glucose transport and transporters by glucose in vascular endothelial and smooth muscle cells. Diabetes. 1993;42: 80-89.
23. Maiello M, Boeri D, Podesta F, Cagliero E, Vichi M, Odetti P, Adezati L, Lorenzi M. Increased expression of tissue plasminogen activator and its inhibitor and reduced fibrinolytic potential of human endothelial cells cultured in elevated glucose. Diabetes. 1992;41:1009-1015.
24. Kooistra T. The use of cultured human endothelial cells and hepatocytes as an in vitro model system to study modulation of endogenous fibrinolysis. Fibrinolysis, 1990;4(suppl 2):33-39.
25. Kooistra T, Bosma PJ, Tons HAM, van den Berg AP, Meyer P, Princen HMG. Plasminogen activator inhibitor 1: biosynthesis and mRNA level are increased by insulin in cultured human hepatocytes. Thromb Haemost. 1989;62:723-728.
26. Hughes HC. Swine in cardiovascular research. Lab Anim Sci. 1986; 36:348-350.
27. 27: Cagliero E, Roth T, Roy S, Maiello M, Lorenzi M. Expression of genes related to the extracellular matrix in human endothelial cells. J Biol Chem. 1991;266:14244-14250.
28. The International Collaborative Group. Joint discussion. J Chronic Dis. 1979;32:829-837.