CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone

Clinical Pharmacology & Therapeutics

Volumn 54, Issue 5, 1993, Pages 463-472

  Otton, S Victoria ^a   Schadel, Mordecai ^a   Cheung, Siu Wah ^a   Kaplan, Howard L ^a   Busto, Usoa E ^a   Sellers, Edward M ^a  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 ISOENZYME; DEXTROMETHORPHAN; DRUG METABOLITE; HYDROCODONE; HYDROMORPHONE; LEVALLORPHAN; ORNEX; QUINIDINE;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG OXIDATION; FEMALE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; LIVER MICROSOME; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PHENOTYPE; PRIORITY JOURNAL;

CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; HUMAN; HYDROCODONE; HYDROMORPHONE; IN VITRO; MALE; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; MUTATION; OXIDATION-REDUCTION; PHENOTYPE; REFERENCE VALUES; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027381603     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.1993.177     Document Type: Article

References (0)