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4
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0025650466
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CD40 and IgE: Synergism between AntiCD40 Monoclonal Antibody and Interleukin 4 in the Induction of IgE Synthesis by Highly Purified Human B Cells
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(1990)
J Exp Med
, vol.172
, pp. 1861-1864
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Jabara1
Fu2
Geha3
Vercelli4
-
5
-
-
0026532658
-
Molecular Analysis of the Induction of Immunoglobuhn E Synthesis in Human B Cells by Interieukin 4 and Engagement of CD40 Antigen
-
of outstanding interest, IgE-isotype switching in highly purified B cells induced by IL-4 and engagement of CD40 occurs by deletional switch recombination; this is demonstrated using a nested polymerase chain reaction method, which detects Sμ/Sϵ switch fragments.
-
(1992)
J Exp Med
, vol.175
, pp. 289-292
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-
Shapira1
Vercelli2
Jabara3
Fu4
Geha5
-
6
-
-
0026528181
-
Molecular and Biologic Characterization of a Murine Ligand for CD40
-
of outstanding interest, Describes the cloning of murine CD40L by screening a mammalian expression library derived from the murine thymoma cell line EL4, after enriching for binding of soluble CD40 by cell sorting. CV1/EBNA cells transfected with murine CD40L induced B-cell proliferation and, in the presence of IL-4, IgE-isotype switching.
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(1992)
Nature
, vol.357
, pp. 80-82
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-
Armitage1
Fanslow2
Strockbine3
Sato4
Clifford5
MacDuff6
Anderson7
Gimpel8
Davis-Smith9
Maliszewski10
-
7
-
-
0026721725
-
Soluble Forms of CD40 Inhibit Biologic Responses of Human B Cells
-
of special interest, IL-4-induced IgE synthesis and soluble CD23 shedding are inhibited by solube CD40 suggesting that the CD40L is induced by IL-4 and that it mediates IL-4-induced IgE synthesis and soluble CD23 shedding.
-
(1992)
J Immunol
, vol.149
, pp. 655-660
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-
Fanslow1
Anderson2
Grabs-Min3
Clark4
Cosman5
Armitage6
-
8
-
-
0024414103
-
A B-Lymphocyte Activa tion Molecule Related to the Nerve Growth Factor Receptor and Induced by Cytokines in Carcinomas
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(1989)
EMBO J
, vol.8
, pp. 1403-1410
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-
Stamenkovic1
Clark2
Seed3
-
9
-
-
0026693906
-
CD40 is Functionally Expressed on Human Thymic Epithelial Cells
-
(1992)
J Immunol
, vol.149
, pp. 775-782
-
-
Galey1
Spits2
-
11
-
-
0026535399
-
Identification of a Novel Surface Protein on Activated CD4+ T Cells that Induces Contact-Dependent B Cell Differentiation (Help)
-
of special interest, This paper identifies human CD40L using a mAb that inhibits T-cell dependent CD23 expression on B cells.
-
(1992)
J Exp Med
, vol.175
, pp. 1091-1101
-
-
Lederman1
Yellin2
Krichevsky3
Belko4
Lee5
Chess6
-
12
-
-
0026772133
-
A 39-kDa Protein on Activated Helper T Cells Binds CD40 and Transduccs the Signal for Cognate Activation of B Cells
-
of special interest, This paper identifies murine CD40L using mAb and soluble CD40, which inhibit Tcell help to B cells.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 6550-6554
-
-
Noelle1
Roy2
Shepherd3
Stamenkovic4
Ledbetter5
Aruffo6
-
13
-
-
0026441086
-
Cloning of TRAP, a Ligand for CD40 on Human T Cells
-
of special interest, Describes the cloning of the gene encoding human CD40L, a protein related to TNF, by screening for genes requiring both phorbol ester and ionophore for expression. The gene encoding CD40L is mapped to Xq26.3-q27.1 by fluorescence in situ hybridization, which allowed the association of CD40L with HIGMX-1.
-
(1992)
Eur J Immunol
, vol.22
, pp. 3191-3194
-
-
Graf1
Korthauer2
MagEs3
Senger4
Kroczek5
-
14
-
-
0026479997
-
The Human T Cell Antigen gp39, a Member of the TNF Gene Family, is a Ligand for the CD40 Receptor: Expression of a Soluble Form of gp39 with B Cell Co-Stimulatory Activity
-
of special interest, Describes the cloning of the gene encoding human CD40L and its homology with TNF. Recombinant soluble CD40L did not induce B-cell proliferation, and COS cells transfected with the gene encoding CD40L induced B-cell proliferation only weakly, but both synergized with CD20 mAb or phorbol ester to induce strong B-cell proliferation.
-
(1992)
EMBO J
, vol.11
, pp. 4313-4321
-
-
Hollenbaugh1
Grosmaire2
Kullas3
Chalupny4
Noelle5
Stamenkovic6
Ledbetter7
Aruffo8
-
22
-
-
0027462664
-
Defective Expression of the CD40 Ligand in X-Chromosomc Linked Immunoglobulin Deficiency with Normal or Elevated IgM
-
of outstanding interest, This paper is important because it demonstrates that patients with HIGMX-1 do not undergo T-cell dependent IgE-isotype switching, but B cells from HIGMX-1 patients respond to CD40 mAb and 1L-4 by undergoing deletional switch recombination to IgE. T cells from HIGMX-1 patients do not express functional CD40L but express mRNA encoding this ligand of normal size and quantity.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 2170-2173
-
-
Fuleihan1
Ramesh2
Loh3
Jabara4
Rosen5
Chatila6
Fu7
Stamenkovic8
Geha9
-
23
-
-
0027199021
-
Deletions in the Ligand for CD40 in X-Linked Immunoglobulin Deficiency with Normal or Elevated IgM (HIGMX-1)
-
of outstanding interest, Describes deletions in the gene encoding CD40L in two unrelated patients with HIGMX-1: one has a 59 base pair deletion and the other has an unusual mutation characterized by a C→A transversion at base pair 590 with the deletion of an adjacent C nucleotide. This paper is the first to demonstrate that in some patients (two out of five studied), a CD40L protein, which does not bind CD40, can be detected on the surface of T cells after activation by a mAb against CD40L. This indicates that the loss of CD40L function, i.e. binding to CD40, is the underlying cause of the isotype-switch defect in these patients.
-
(1993)
Int Immunol
, vol.5
, pp. 769-773
-
-
Ramesh1
Fuleihan2
Ramesh3
Lederman4
Yellin5
Sharma6
Chess7
Rosen8
Geha9
-
25
-
-
0027394391
-
The CD40 Ligand, gp39, is Defective in Activated T Cells from Patients with X-Linked Hyper-IgM Syndrome
-
of outstanding interest, This paper describes the investigation of CD40-CD40L interaction in patients with antibody-deficiency diseases. HIGMX-1 patients were found to lack surface expression of CD40L in contrast with common variable immunodeficiency or X-linked agammaglobulinemia patients. Two HIGMX-1 patients were found to have point mutations in the CD40L coding sequence. Soluble recombinant forms of mutated CD40L failed to bind CD40 or to induce B-cell proliferation, whereas B cells from HIGMX-1 patients synthesized IgE in response to CD40 mAb+IL-4. In addition, the CD40L gene was mapped to Xq26.
-
(1993)
Cell
, vol.72
, pp. 291-300
-
-
Aruffo1
Farrington2
Hollenbaugh3
Li4
Milatovich5
Nonoyama6
Bajorath7
Grosmaire8
Stenkamp9
Neubauer10
Roberts11
-
26
-
-
0027414691
-
CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome
-
of outstanding interest, This paper describes defects in the CD40L coding sequence in HIGMX-1 patients. Single amino acid substitutions were found in three out of four of the patients studied. The fourth patient had normal coding sequence suggesting that the 5′ 3′coding sequences were responsible for the lack of CD40L expression on the surface. Patient B cells responded to wild-type CD40L or to CD40 mAb.
-
(1993)
Science
, vol.259
, pp. 990-993
-
-
Allen1
Armitage2
Conley3
Rosenblatt4
Jenkins5
Copeland6
Bedell7
Edelhoff8
Disteche9
Simoneaux10
-
27
-
-
0027533185
-
Defective Expression of TCell CD40 Ligand Causes X-Linked Immunodeficiency with Hyper-IgM
-
of outstanding interest, This paper describes point mutations in the CD40L coding sequences in three patients with HIGMX-1 that result in failure to bind CD40. Two out of three patients expressed a protein which was detectable by rabbit polyclonal antibodies. Patients B cells secreted IgG and IgA when stimualted with CD40 mAb, Staphylococcus aureus Cowan I and IL-10.
-
(1993)
Nature
, vol.361
, pp. 539-541
-
-
Korthauer1
Graf2
Mages3
Briere4
Padayachee5
Malcolm6
Ugazio7
Notarangelo8
Levinsky9
Kroczek10
-
28
-
-
0027398544
-
CD40 Ligand Mutations in X-Linked Immunodeficiency with Hyper-IgM
-
of outstanding interest, This paper describes a lack of CD40L surface expression in four patients with HIGMX-1. Three patients had deletions within the CD40L coding sequence, only one of which was an in-frame deletion, and the fourth patient had a point mutation.
-
(1993)
Nature
, vol.361
, pp. 541-543
-
-
DiSanto1
Bonnefoy2
Gauchat3
Fischer4
de Saint Basile5
-
31
-
-
0021227676
-
The Role of Protein Kinase C in Cell Surface Signal Transduction and Tumour Promotion
-
(1984)
Nature
, vol.308
, pp. 693-698
-
-
Nishizuka1
-
32
-
-
0021750054
-
Inositol Trisphosphate, a Novel Second Messenger in Cellular Signal Transduction
-
(1984)
Nature
, vol.312
, pp. 315-321
-
-
Berridge1
Irvine2
-
33
-
-
0021917674
-
Transmembrane Signaling by the T Cell Antigen Receptor; Perturbation of the T3-Antigen Receptor Complex Generates Inositol Phosphates and Re leases Calcium Ions from Intracellular Stores
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(1985)
J Exp Med
, vol.161
, pp. 446-456
-
-
Imboden1
Stobo2
-
40
-
-
0026478651
-
Rescue from Anti-IgM-Induced Programmed Cell Death by the B Cell Surface Proteins CD20 and CD40
-
(1992)
Eur J Immunol
, vol.22
, pp. 3141-3148
-
-
Valentine1
Licciardi2
-
41
-
-
0025891769
-
CD40 Signaling Activates CDlla/CD18 (LFA-1)Mediated Adhesion in B Cells
-
(1991)
J Immunol
, vol.146
, pp. 1722-1729
-
-
Barrett1
Shu2
Clark3
-
42
-
-
0026343687
-
Transmembranc Signals Generated Through MHC Class II, CD19, CD20, CD39, and CD40 Antigens Induce LFA-1-Dependent and Independent Adhesion in Human B Cells Through a Tyrosine Kinase-Dependent Pathway
-
(1991)
J Immunol
, vol.147
, pp. 4094-4102
-
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Kansas1
Tedder2
-
44
-
-
0025955702
-
Stimulation of Protein Tyrosine Phosphorylation, Phosphoinositide Turnover, and Multiple Previously Unidentified Serine/Threonine-Specific Protein Kinases by the Pan-BCell Receptor CD40/Bp50 at Discrete Developmental Stages of Human B-Cell Ontogeny
-
(1991)
J Biol Cbem
, vol.266
, pp. 17478-17485
-
-
Uckun1
Schieven2
Dibirdik3
Chandan-Langlie4
Tuel-Ahlgren5
Ledbetter6
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