Biotransformation of lovastatin. V. Species differences in in vivo metabolite profiles of mouse, rat, dog, and human

Drug Metabolism and Disposition

Volumn 21, Issue 6, 1993, Pages 1003-1011

  Halpin, R A ^a   Ulm, E H ^a   Till, A E ^a   Kari, P H ^a   Vyas, K P ^a   Hunninghake, D B ^a   Duggan, D E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; DRUG METABOLITE; MEVINOLIN; TAURINE; VALERIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; CASE REPORT; DOG; DRUG CONJUGATION; DRUG HYDROLYSIS; DRUG HYDROXYLATION; DRUG OXIDATION; DRUG TRANSFORMATION; FATTY ACID OXIDATION; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; MALE; MOUSE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RADIOCHROMATOGRAPHY; RAT; SPECIES DIFFERENCE;

ANIMAL; BILE; BILIARY TRACT; BIOTRANSFORMATION; COMPARATIVE STUDY; DOGS; FEMALE; GALLBLADDER; HUMAN; LIVER; LOVASTATIN; MALE; MICE; MICE, INBRED STRAINS; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY;

EID: 0027378356     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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