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Volumn 22, Issue 5, 1993, Pages 783-795

Cancer Chemoprotection by Oltipraz: Experimental and Clinical Considerations

Author keywords

[No Author keywords available]

Indexed keywords

AFLATOXIN; AZOXYMETHANE; BENZO[A]PYRENE; BETA CAROTENE; CYTOCHROME P450; DIETHYLNITROSAMINE; DIMETHYLBENZ[A]ANTHRACENE; EFLORNITHINE; FENRETINIDE; GLUTATHIONE; N BUTYL N (4 HYDROXYBUTYL)NITROSAMINE; OLTIPRAZ; URAMUSTINE;

EID: 0027377850     PISSN: 00917435     EISSN: None     Source Type: Journal    
DOI: 10.1006/pmed.1993.1072     Document Type: Article
Times cited : (25)

References (63)
  • 1
    • 0039151214 scopus 로고
    • The chemistry of the 1, 2-dithiole ring
    • Kharasch N, Meyers CY, Eds., Oxford: Pergamon
    • Lozac’h N, Vialle J. The chemistry of the 1, 2-dithiole ring. In: Kharasch N, Meyers CY, Eds. The Chemistry of Organic Sulfur Compounds, Vol. 2. Oxford: Pergamon, 1966: 257-285.
    • (1966) The Chemistry of Organic Sulfur Compounds , vol.2 , pp. 257-285
    • Lozac’h, N.1    Vialle, J.2
  • 4
    • 0019134347 scopus 로고
    • Assessment of 35972 RP (Oltipraz) a new antischistosomal drug against Schistosoma haematobium, Schistosoma monsoni, and Schistosoma intercalatum
    • Gentilini M, Duflo B, Richard-Lenoble D, Brucker G, Danis M, Niel G, Meunier Y. Assessment of 35972 RP (Oltipraz) a new antischistosomal drug against Schistosoma haematobium, Schistosoma monsoni, and Schistosoma intercalatum. Acta Trap 1980; 37:271-274.
    • (1980) Acta Trap , vol.37 , pp. 271-274
    • Gentilini, M.1    Duflo, B.2    Richard-Lenoble, D.3    Brucker, G.4    Danis, M.5    Niel, G.6    Meunier, Y.7
  • 5
    • 0021132372 scopus 로고
    • Comparative study of oltipraz versus praziquantel for treat ment of schistosomiasis with intestinal manifestation in the Gabon (Schistosoma intercalatum and 5. Haematobium)
    • Kern P, Burchard GD, Dietrich M. Comparative study of oltipraz versus praziquantel for treat ment of schistosomiasis with intestinal manifestation in the Gabon (Schistosoma intercalatum and 5. haematobium). Tropenmed Parasitol 1984; 35:95-99.
    • (1984) Tropenmed Parasitol , vol.35 , pp. 95-99
    • Kern, P.1    Burchard, G.D.2    Dietrich, M.3
  • 7
    • 0018422752 scopus 로고
    • Clinical study with a sialagogue drug (Sulfarlem S 25 = TTPT) in the treatment of xerostomia
    • Hausler R, Ritschard J. Clinical study with a sialagogue drug (Sulfarlem S 25 = TTPT) in the treatment of xerostomia. Rev Suisse Praxis Med 1979; 68:1063-1068.
    • (1979) Rev Suisse Praxis Med , vol.68 , pp. 1063-1068
    • Hausler, R.1    Ritschard, J.2
  • 9
    • 0025362496 scopus 로고
    • Effect of oltipraz on the susceptibility of adult Schistosoma mansoni to killing by mouse peritoneal exudate cells
    • Mkoji GM, Smith JM, Pritchard RK. Effect of oltipraz on the susceptibility of adult Schistosoma mansoni to killing by mouse peritoneal exudate cells. Parisilol Res 1990; 76:435-439.
    • (1990) Parisilol Res , vol.76 , pp. 435-439
    • Mkoji, G.M.1    Smith, J.M.2    Pritchard, R.K.3
  • 11
    • 0018116175 scopus 로고
    • Elevation of hepatic glutathione 5-transferase activities and protection against mutagenic metabolites of benzo[a]py-rene by dietary antioxidants
    • Benson AM, Batzinger RP, Ou S-YL, Bueding E, Cha Y-N, Talalay P. Elevation of hepatic glutathione 5-transferase activities and protection against mutagenic metabolites of benzo[a]py-rene by dietary antioxidants. Cancer Res 1978; 38:4486-4495.
    • (1978) Cancer Res , vol.38 , pp. 4486-4495
    • Benson, A.M.1    Batzinger, R.P.2    Ou, S.-Y.3    Bueding, E.4    Cha, Y.-N.5    Talalay, P.6
  • 12
    • 0018760217 scopus 로고
    • Elevation of extrahepatic gluthathione 5-transferase and epoxide hydratase activities by 2(3)-tert-butyl-4-hydroxyanisole
    • Benson AM, Cha Y-N, Bueding E, Heine HS, Talalay P. Elevation of extrahepatic gluthathione 5-transferase and epoxide hydratase activities by 2(3)-tert-butyl-4-hydroxyanisole. Cancer Res 1979; 39:2971-2977.
    • (1979) Cancer Res , vol.39 , pp. 2971-2977
    • Benson, A.M.1    Cha, Y.-N.2    Bueding, E.3    Heine, H.S.4    Talalay, P.5
  • 13
    • 0021082001 scopus 로고
    • Chemoprotective effects of two dithiolethiones and of butylhy-droxyanisole against carbon tetrachloride and acetaminophen toxicity
    • Ansher SS, Dolan P, Bueding E. Chemoprotective effects of two dithiolethiones and of butylhy-droxyanisole against carbon tetrachloride and acetaminophen toxicity. Hepatology 1983; 3:932-935.
    • (1983) Hepatology , vol.3 , pp. 932-935
    • Ansher, S.S.1    Dolan, P.2    Bueding, E.3
  • 14
    • 0011832190 scopus 로고
    • Role of glutathione in oltipraz-induced protection in acetaminophen or allyl alcohol hepatotoxicity in the male hamster
    • Davies MH, Schamber GJ, Schnell RC. Role of glutathione in oltipraz-induced protection in acetaminophen or allyl alcohol hepatotoxicity in the male hamster. The Toxicologist 1987; 7:219.
    • (1987) The Toxicologist , vol.7 , pp. 219
    • Davies, M.H.1    Schamber, G.J.2    Schnell, R.C.3
  • 15
    • 0025847596 scopus 로고
    • Oltipraz-induced amelioration of acetaminophen hepato toxicity in hamsters
    • Davies MH, Schamber GJ, Schnell RC. Oltipraz-induced amelioration of acetaminophen hepato toxicity in hamsters. Toxicol Appl Pharmacol 1991; 109:17-28.
    • (1991) Toxicol Appl Pharmacol , vol.109 , pp. 17-28
    • Davies, M.H.1    Schamber, G.J.2    Schnell, R.C.3
  • 16
    • 0023938523 scopus 로고
    • Protection by 5-(2-pyrazinyl)-4-methyl-l, 2-dithiol-3-thione (oltipraz) against the hepatotoxicity of aflatoxin B, in the rat
    • Liu L-Y, Roebuck BD, Yager JD, Groopman JD, Kensler TW. Protection by 5-(2-pyrazinyl)-4-methyl-l, 2-dithiol-3-thione (oltipraz) against the hepatotoxicity of aflatoxin B, in the rat. Toxicol Appl Pharmacol 1988; 93:442-451.
    • (1988) Toxicol Appl Pharmacol , vol.93 , pp. 442-451
    • Liu, L.-Y.1    Roebuck, B.D.2    Yager, J.D.3    Groopman, J.D.4    Kensler, T.W.5
  • 17
    • 0022763396 scopus 로고
    • Inhibitory effects of 5-(2-pyrazinyl)-4-methyl-l, 2-dithiol-3-thione (oltipraz) on carcinogenesis induced by benzo[a]pyrene, diethylnitrosamine and uracil mustard
    • Wattenberg LW, Bueding E. Inhibitory effects of 5-(2-pyrazinyl)-4-methyl-l, 2-dithiol-3-thione (oltipraz) on carcinogenesis induced by benzo[a]pyrene, diethylnitrosamine and uracil mustard Carcinogenesis 1986; 7:1379-1381.
    • (1986) Carcinogenesis , vol.7 , pp. 1379-1381
    • Wattenberg, L.W.1    Bueding, E.2
  • 18
    • 0025783095 scopus 로고
    • Inhibition by dietary oltipraz of experimental intestinal carcinogenesis induced by azoxymethane in male F344 rats
    • Rao CV, Tokomo K, Kelloff G, Reddy BS. Inhibition by dietary oltipraz of experimental intestinal carcinogenesis induced by azoxymethane in male F344 rats. Carcinogenesis 1991; 12:1051-1055.
    • (1991) Carcinogenesis , vol.12 , pp. 1051-1055
    • Rao, C.V.1    Tokomo, K.2    Kelloff, G.3    Reddy, B.S.4
  • 19
    • 0025925257 scopus 로고
    • Protection against aflatoxin B,-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-l, 2-dithiole-3-thione (oltipraz): Predictive role for short-term molecular dosimetry
    • Roebuck BD, Liu Y-L, Rogers AR, Groopman JD, Kensler TW. Protection against aflatoxin B,-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-l, 2-dithiole-3-thione (oltipraz): Predictive role for short-term molecular dosimetry. Cancer Res 1991; 51:5501-5506.
    • (1991) Cancer Res , vol.51 , pp. 5501-5506
    • Roebuck, B.D.1    Liu, Y.-L.2    Rogers, A.R.3    Groopman, J.D.4    Kensler, T.W.5
  • 20
    • 0023204238 scopus 로고
    • Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-l, 2-dithiol-3-thione (oltipraz) and related 1, 2-dithiole-3-thione and l, 2-dithiol-3-ones
    • Kensler TW, Egner PA, Dolan PM, Groopman JD, Roebuck BD. Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-l, 2-dithiol-3-thione (oltipraz) and related 1, 2-dithiole-3-thione and l, 2-dithiol-3-ones. Cancer Res 1987; 47:4271-4277.
    • (1987) Cancer Res , vol.47 , pp. 4271-4277
    • Kensler, T.W.1    Egner, P.A.2    Dolan, P.M.3    Groopman, J.D.4    Roebuck, B.D.5
  • 21
    • 0026604162 scopus 로고
    • Effects of sulindac and oltipraz on the tumorige nicity of 4-(Methylnitrosamino)l-(3-pyridyl)-l-butanone in A/J mouse lung
    • Pepin P, Bouchard L, Nicole P, Castonguay A. Effects of sulindac and oltipraz on the tumorige nicity of 4-(methylnitrosamino)l-(3-pyridyl)-l-butanone in A/J mouse lung. Carcinogenesis 1992; 13:341-348.
    • (1992) Carcinogenesis , vol.13 , pp. 341-348
    • Pepin, P.1    Bouchard, L.2    Nicole, P.3    Castonguay, A.4
  • 23
    • 0011928656 scopus 로고
    • Retinoid chemoprevention of lung cancer
    • Wattenberg LW, Boone CW, Kelloff GJ, Lipkin M, Eds., CRC Press, In press
    • Moon RC, Rao KVN, Detrisac CJ, Kelloff GJ. Retinoid chemoprevention of lung cancer. In: Wattenberg LW, Boone CW, Kelloff GJ, Lipkin M, Eds. Cancer Chemoprevention, Boca Raton: CRC Press, 1992. In press.
    • (1992) Cancer Chemoprevention, Boca Raton
    • Moon, R.C.1    Rao, K.2    Detrisac, C.J.3    Kelloff, G.J.4
  • 25
    • 0018180853 scopus 로고
    • The major metabolite of aflatoxin Bj in the rat is a glutathione conjugate
    • Degan GH, Neumann HG. The major metabolite of aflatoxin Bj in the rat is a glutathione conjugate. Chem-Biol Interact 1978; 22:239-255.
    • (1978) Chem-Biol Interact , vol.22 , pp. 239-255
    • Degan, G.H.1    Neumann, H.G.2
  • 26
    • 0021893276 scopus 로고
    • Modification of aflatoxin B, binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquin and a dithiolethione
    • Kensler TW, Egner PA, Trush MA, Bueding E, Groopman JD. Modification of aflatoxin B, binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquin and a dithiolethione. Carcinogenesis 1985; 6:759-763.
    • (1985) Carcinogenesis , vol.6 , pp. 759-763
    • Kensler, T.W.1    Egner, P.A.2    Trush, M.A.3    Bueding, E.4    Groopman, J.D.5
  • 28
    • 0022261891 scopus 로고
    • Studies on the detoxication of microso-mally-activated aflatoxin B, by glutathione and glutathione transferases in vitro
    • Coles B, Meyer DJ, Ketterer B, Stanton CA, Garner RC. Studies on the detoxication of microso-mally-activated aflatoxin B, by glutathione and glutathione transferases in vitro. Carcinogenesis 1985; 6:693-697.
    • (1985) Carcinogenesis , vol.6 , pp. 693-697
    • Coles, B.1    Meyer, D.J.2    Ketterer, B.3    Stanton, C.A.4    Garner, R.C.5
  • 30
    • 0025238457 scopus 로고
    • Transcriptional control of glutathione S-transferase gene expression by the chemoprotective agent 5-(2-pyrazinyl)-4-methyl-l, 2-dithiole-3-thione (olti-praz) in rat liver
    • Davidson NE, Egner PA, Kensler TW. Transcriptional control of glutathione S-transferase gene expression by the chemoprotective agent 5-(2-pyrazinyl)-4-methyl-l, 2-dithiole-3-thione (olti-praz) in rat liver. Cancer Res 1990; 50:2251-2255.
    • (1990) Cancer Res , vol.50 , pp. 2251-2255
    • Davidson, N.E.1    Egner, P.A.2    Kensler, T.W.3
  • 31
    • 0025368036 scopus 로고
    • Regulation of glutathione S-transferase Ya subunit gene expression: Identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds
    • Rushmore TH, King RG, Paulson KE, Pickett CB. Regulation of glutathione S-transferase Ya subunit gene expression: Identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds. Proc Natl Acad Sei USA 1990; 87:3826-3830.
    • (1990) Proc Natl Acad Sei USA , vol.87 , pp. 3826-3830
    • Rushmore, T.H.1    King, R.G.2    Paulson, K.E.3    Pickett, C.B.4
  • 32
    • 0000639115 scopus 로고
    • Effects of three chemoprotective antioxidants, ethoxyquin, oltipraz and l, 2-dithiole-3-thione, on cytochrome P-450 levels and aflatoxin B, metabolism
    • Putt DA, Kensler TW, Hollenberg PF. Effects of three chemoprotective antioxidants, ethoxyquin, oltipraz and l, 2-dithiole-3-thione, on cytochrome P-450 levels and aflatoxin B, metabolism. FASEBJ 1991; 5:A1517.
    • (1991) FASEBJ , vol.5 , pp. A1517
    • Putt, D.A.1    Kensler, T.W.2    Hollenberg, P.F.3
  • 33
    • 0025992864 scopus 로고
    • Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes
    • Guengerich FP, Shimada T. Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes. Chem Res Toxicol 1991; 4:391—407.
    • (1991) Chem Res Toxicol , vol.4 , pp. 391-407
    • Guengerich, F.P.1    Shimada, T.2
  • 34
    • 0022497046 scopus 로고
    • Modulation of aflatoxin metabolism, aflatoxin-N7-guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: Role of induction of glutathione S-transferases
    • 7-guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: role of induction of glutathione S-transferases. Cancer Res 1986; 46:3924-3931.
    • (1986) Cancer Res , vol.46 , pp. 3924-3931
    • Kensler, T.W.1    Egner, P.A.2    Davidson, N.E.3    Roebuck, B.D.4    Pikul, A.5    Groopman, J.D.6
  • 35
    • 0025168534 scopus 로고
    • Cell proliferation in carcinogenesis
    • Cohen SM, Ellwein LB. Cell proliferation in carcinogenesis. Science 1990; 249:1007-1011.
    • (1990) Science , vol.249 , pp. 1007-1011
    • Cohen, S.M.1    Ellwein, L.B.2
  • 36
    • 0023775635 scopus 로고
    • The design of cancer prevention trials
    • Byar DP. The design of cancer prevention trials. Recent Results Cancer Res 1988; 111:24—48.
    • (1988) Recent Results Cancer Res , vol.111 , pp. 24-48
    • Byar, D.P.1
  • 37
    • 0001140597 scopus 로고
    • Study of 4-methyl-5-(2-pyrazinyl)-l, 2-dithiole-3-thiol [oltipraz: RP 35972] in male patients with previously resected colon polyps and first degree relatives of breast cancer patients
    • Benson AB III, Mobarhan S, Ratain M, Sheehan T, Berezin F, Giovanazzi-Bannon S, Ford C, Rademaker A. Phase I study of 4-methyl-5-(2-pyrazinyl)-l, 2-dithiole-3-thiol [oltipraz: RP 35972] in male patients with previously resected colon polyps and first degree relatives of breast cancer patients. Proc Am Assoc Clin Oncol 1992; 11:145.
    • (1992) Proc am Assoc Clin Oncol , vol.11 , pp. 145
    • Benson, A.1    Mobarhan, S.2    Ratain, M.3    Sheehan, T.4    Berezin, F.5    Giovanazzi-Bannon, S.6    Ford, C.7    Rademaker, A.8    Phase, I.9
  • 39
    • 1842557101 scopus 로고
    • Pharmacokinetic study of 4-methyl-5(2-pyrazinyl)-l, 1-dithiole-3-thione (oltipraz) in normal volunteers
    • Berezin F, Ratain MJ, Benson AB III. Pharmacokinetic study of 4-methyl-5(2-pyrazinyl)-l, 1-dithiole-3-thione (oltipraz) in normal volunteers. Proc Am Assoc Cancer Res 1992; 33:208.
    • (1992) Proc am Assoc Cancer Res , vol.33 , pp. 208
    • Berezin, F.1    Ratain, M.J.2    Benson, A.B.3
  • 40
    • 0025811288 scopus 로고
    • Effect of oltipraz [5-(2-pyrazinyl)-methyl-l, 2-dithiole-3-thione] on azoxymethane-induced biochemical changes related to early colon carcinogenesis in male F344 rats
    • Rao CV, Nayini J, Reddy BS. Effect of oltipraz [5-(2-pyrazinyl)-methyl-l, 2-dithiole-3-thione] on azoxymethane-induced biochemical changes related to early colon carcinogenesis in male F344 rats. Proc Soc Exp Biol Med 1991; 197:77-84.
    • (1991) Proc Soc Exp Biol Med , vol.197 , pp. 77-84
    • Rao, C.V.1    Nayini, J.2    Reddy, B.S.3
  • 41
    • 0022739951 scopus 로고
    • 1, 2-Dithiol-3-thione analogs: Effects on NAD-(P)H:Quinone reductase and glutathione levels in murine hepatoma cells
    • De Long MJ, Dolan P, Santamaria AB, Bueding E. 1, 2-Dithiol-3-thione analogs: effects on NAD-(P)H:quinone reductase and glutathione levels in murine hepatoma cells. Carcinogenesis 1986; 7:977-980.
    • (1986) Carcinogenesis , vol.7 , pp. 977-980
    • De Long, M.J.1    Dolan, P.2    Santamaria, A.B.3    Bueding, E.4
  • 42
    • 0026041457 scopus 로고
    • Induction of NADP(P)H:Quinone reductase in human peripheral blood lymphocytes
    • Gordon GB, Prochaska HJ, Yang LY-S. Induction of NADP(P)H:quinone reductase in human peripheral blood lymphocytes. Carcinogenesis 1991; 12:2392-2396.
    • (1991) Carcinogenesis , vol.12 , pp. 2392-2396
    • Gordon, G.B.1    Prochaska, H.J.2    Yang, L.-S.3
  • 49
    • 84945773034 scopus 로고
    • Occupational Diseases: A Guide to Their Recognition
    • United States Department of Health, Education, and Welfare, National Institute for Occupational Safety and Health. Occupational Diseases: A Guide to Their Recognition. 1977: 471-472.
    • (1977) National Institute for Occupational Safety and Health , pp. 471-472
  • 53
    • 0001142255 scopus 로고
    • Chromosome aberrations induced by ionizing radiations
    • Evans HJ. Chromosome aberrations induced by ionizing radiations. Int Rev Cytol 1962; 13:221-321.
    • (1962) Int Rev Cytol , vol.13 , pp. 221-321
    • Evans, H.J.1
  • 54
    • 0022642022 scopus 로고
    • Urine mutagenicity, chromosomal abnormalities and sister chromatid exchanges in lymphocytes of nurses handling cytostatic drugs
    • Stucker I, Hirsch A, Doloy T, Bastie-Sigeac I, Hemon D. Urine mutagenicity, chromosomal abnormalities and sister chromatid exchanges in lymphocytes of nurses handling cytostatic drugs. Int Arch Occup Environ Health 1986; 57:195-205.
    • (1986) Int Arch Occup Environ Health , vol.57 , pp. 195-205
    • Stucker, I.1    Hirsch, A.2    Doloy, T.3    Bastie-Sigeac, I.4    Hemon, D.5
  • 56
    • 0019364918 scopus 로고
    • Excretion of an aflatoxin-guanine adduct in urine of aflatoxin B,-treated rats
    • Bennett RA, Essigmann JM, Wogan GN. Excretion of an aflatoxin-guanine adduct in urine of aflatoxin B,-treated rats. Cancer Res 1981; 41:650-654.
    • (1981) Cancer Res , vol.41 , pp. 650-654
    • Bennett, R.A.1    Essigmann, J.M.2    Wogan, G.N.3
  • 57
    • 0026602053 scopus 로고
    • Molecular dosimetry in rat urine of aflatoxin-N7-guanine and other aflatoxin metabolites by multiple monoclonal antibody affinity chromatography and immunoaffinity/high performance liquid chromatography
    • 7-guanine and other aflatoxin metabolites by multiple monoclonal antibody affinity chromatography and immunoaffinity/high performance liquid chromatography. Cancer Res 1992; 52:267-274.
    • (1992) Cancer Res , vol.52 , pp. 267-274
    • Groopman, J.D.1    Hasler, J.A.2    Trudel, L.J.3    Pikul, A.4    Donahue, P.R.5    Wogan, G.N.6
  • 58
    • 0026505034 scopus 로고
    • Molecular dosimetry of urinary aflatoxin-DNA adducts in people living in Guangxi Autonomous Region, People’s Republic of China
    • Groopman JD, Zhu J, Donahue PR, Pikul A, Zhang L, Chen J, Wogan GN. Molecular dosimetry of urinary aflatoxin-DNA adducts in people living in Guangxi Autonomous Region, People’s Republic of China. Cancer Res 1992; 52:45-52.
    • (1992) Cancer Res , vol.52 , pp. 45-52
    • Groopman, J.D.1    Zhu, J.2    Donahue, P.R.3    Pikul, A.4    Zhang, L.5    Chen, J.6    Wogan, G.N.7
  • 59
    • 0026501157 scopus 로고
    • Molecular dosimetry of urinary aflatoxin-N7-guanine and serum aflatoxin-albumin adducts predicts chemoprotection by 1, 2-dithiole-3-thione in rats
    • 7-guanine and serum aflatoxin-albumin adducts predicts chemoprotection by 1, 2-dithiole-3-thione in rats. Carcinogenesis 1992; 13:101-106.
    • (1992) Carcinogenesis , vol.13 , pp. 101-106
    • Groopman, J.D.1    Dematos, P.2    Egner, P.A.3    Love-Hunt, A.4    Kensler, T.W.5
  • 60
    • 0026864713 scopus 로고
    • Patients' perceptions on participation in a cancer chemo prevention trial
    • Tangrea JA, Adrianza ME, Helsel WE. Patients' perceptions on participation in a cancer chemo prevention trial. Cancer Epi Biomarkers Prev 1992; 1:325-330.
    • (1992) Cancer Epi Biomarkers Prev , vol.1 , pp. 325-330
    • Tangrea, J.A.1    Adrianza, M.E.2    Helsel, W.E.3
  • 61
    • 0025021731 scopus 로고
    • Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: A review
    • Boone CW, Kelloff GJ, Malone WE. Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: A review. Cancer Res 1990; 50:2-9.
    • (1990) Cancer Res , vol.50 , pp. 2-9
    • Boone, C.W.1    Kelloff, G.J.2    Malone, W.E.3


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