Effect of glutamate receptor antagonists on N-methyl-D-aspartate- and (S)-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced convulsant effects in mice and rats

European Journal of Pharmacology

Volumn 242, Issue 3, 1993, Pages 213-220

  Bisaga, Adam ^a   Krzascik, Pawel ^a   Jankowska, Ewa ^a   Palejko, Wojciech ^a   Kostowski, Wojciech ^a   Danysz, Wojciech ^b  

^a INSTITUTE OF PSYCHIATRY AND NEUROLOGY   (Poland)

^b MERZ PHARMACEUTICALS GMBH   (Germany)

Author keywords

(Mouse); (Neonatal rat); (Rat); (Screening); AMPA ((S) amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid); Convulsions; NMDA (N methyl D aspartate)

Indexed keywords

1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 1 AMINOCYCLOBUTANECARBOXYLIC ACID; 1 AMINOCYCLOPROPANECARBOXYLIC ACID; 2 AMINO 4 METHYL 5 PHOSPHONO 3 PENTENOIC ACID; 3 AMINO 1 HYDROXY 2 PYRROLIDINONE; 5,7 DICHLOROKYNURENIC ACID; 5,7 DINITRO 2,3 QUINOXALINEDIONE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMINO ACID RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR STIMULATING AGENT; AMPA RECEPTOR; CYCLOSERINE; DIZOCILPINE; EXCITATORY AMINO ACID RECEPTOR; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; GLYCINE RECEPTOR; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PARTIAL AGONIST;

AGONIST; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CONVULSION; DRUG ANTAGONISM; FEMALE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRINSIC ACTIVITY; MALE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMAL; ANTICONVULSANTS; COMPARATIVE STUDY; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; MALE; MICE; N-METHYLASPARTATE; RATS; RATS, WISTAR;

EID: 0027375017     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(93)90244-C     Document Type: Article

References (54)

1. Activity of 5,7-dichlorokynurenic acid, a potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site
2. Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels
3. Divalent ion permeability of AMPA receptor channels Is dominated by the edited form of a single subunit
4. Agents which antagonize the NMDA receptor-channel complex in vivo also cause disturbances of motor coordination
5. Effect of NMDA antagonists and non-NMDA antagonists in experimental models of epilepsy
6. The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI-52466, in mice
7. Effect of NMDA-insensitive and strychnine-insensitive glycine site antagonists on NMDA-mediated convulsions and learning
8. Amnesic properties of glutamate receptor antagonists
9. Modulation of glutamate receptors by phencyclidine and glycine in the rat cerebellum: cGMP increase in vivo
10. GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses
11. Glycine reverses antagonism of N-methyl-D-aspartate (NMDA) by 1-hydroxy-3-aminopyrrolidone-2 (HA-966) but not by d-2-amino-5-phosphonovalerate (D-AP5) on rat cortical slices
12. The novel anticonvulsant MK-801 binds to the activated state of the N-methyl-D-aspartate receptor in rat brain
13. D-Cycloserine: a ligand for the N-methyl-D-aspartate coupled glycine receptors has partial agonist characteristics
14. 1-Aminocyclobutane-1-carboxylate (ACBC): a specific antagonist of the N-methyl-D-aspartate receptor coupled glycine receptor
15. Permeability and vascularity of the developing brain: cerebellum vs. cerebral cortex
16. Glycine potentiates the NMDA response in cultured mouse brain neurons
17. Requirement for glycine in activation of NMDA receptors expressed in Xenopus oocytes
18. Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA receptor antagonists and putative glycine antagonists — relationship with phencyclidine-like behavioral effects
19. Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel — a human postmortem brain study
20. N-Methyl-D-aspartic acid-induced lethality in mice: selective antagonism by phencyclidine-like drugs
21. A simplified method of evaluation dose response-effect experiments
22. Noncompetitive excitatory amino acid receptor antagonists
23. Anticonvulsant and behavioral effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP-37849 and CGP-39551, in the kindling model of epilepsy — comparison with MK-801 and carbamazepine
24. 1-aminocyclopropane carboxylic acid: a potent and selective ligand for the glycine modulatory site of the N-methyl-D-aspartate receptor complex
25. 2+ in mammalian neurons
26. N-Methyl-D-aspartate receptor antagonists and channel blockers have different effects upon a spinal seizure model in mice
27. HA-966(1-hydroxy-3-aminopyrrolidone-2) selectively reduces N-methyl-D-aspartate (NMDA)-mediated brain damage
28. Excitatory amino acid neurotoxicity and neurodegenerative disease
29. D-cycloserine, a positive modulator od the N-methyl-D-aspartate receptor, enhances performance of learning tasks in rats
30. 1-Aminocyclopentane-1-carboxylic acid (ACC) mimics the effects of glycine on the NMDA receptor ion channel
31. GYKI-52466 antagonizes glutamate responses but not NMDA and kainate responses in rat abducens motoneurones
32. Classification of compounds for prevention of NMDLA-induced seizures/mortality, or maximal electroshock antagonism of MK-801 binding in vitro
33. In vitro and in vivo characterization of the NMDA receptor-linked strychnine-insensitive glycine site
34. Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-methyl-D-aspartate receptor complex
35. Neuropharmacological characterization of 1-aminocyclopropane-1-carboxylate and 1-aminocyclobutane-1-carboxylate, ligands of the N-methyl-D-aspartate-associated glycine receptor
36. Anticataleptic potencies of glutamate-antagonists
37. The competitive NMDA receptor antagonists CGP 37849 and CGP 39551 are potent oraly-active anticonvulsants in rodents
38. Excitatory amino acid-induced convulsions in neonatal rats mediated by distinct receptor subtypes
39. A potent antagonist of the strychnine insensitive glycine receptor has anticonvulsant properties
40. 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline — a neuroprotectant for cerebral ischemia
41. Modulation of seizure susceptibility in the mouse by the strychnine-insensitive glycine recognition site of the NMDA receptor ion channel complex
42. A slow intravenous infusion of N-methyl-DL-aspartate as a seizure model in the mouse
43. Blockade of N-methyl-D-aspartate induced convulsions by 1-aminocyclopropanecarboxylates
44. The glycine-site NMDA receptor antagonist, R-(+)-cis-ß-methyl-3-amino-1-hydroxypyrrolid-2-one, L-687,414 is anticonvulsant in baboons
45. The non-N-methyl-D-aspartate receptor antagonists, GYKI-52466 and NBQX are anticonvulsant in two animal models of reflex epilepsy
46. 1-Aminocyclopropanecarboxylates exhibit antidepressant and anxiolytic actions in animal models
47. Anxiolytic properties of 1-aminocyclopropanecarboxylic acid, a ligand at strychnine-insensitive glycine receptors
48. Effect of glycine and glycine receptor antagonists on NMDA-induced brain injury
49. Different stereoselectivity of the enantiomers of HA-966 (3-amino-1-hydroxy-2-pyrrolidinone) for neuroprotective and anticonvulsant actions in vivo
50. Excitatory amino acid transmitters
51. Glycine antagonist action of 1-aminocyclobutane-1-carboxylate (ACBC) in Xenopus oocytes injected with rat brain mRNA
52. Modulation of the NMDA receptor by polyamines
53. Modulators of N-methyl-D-aspartate protect against diazepam-resistant or phenobarbital-resistant cocaine convulsions
54. Modulation of glutamate receptors: molecular mechanisms and functional implications