Effect of combined supplementation with α-tocopherol, ascorbate, and beta carotene on low-density lipoprotein oxidation

Circulation

Volumn 88, Issue 6, 1993, Pages 2780-2786

  Jialal, I ^a   Grundy, S M ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Antioxidants; Lipids; Lipoproteins

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; BETA CAROTENE; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; TRIACYLGLYCEROL;

ARTICLE; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; DIET SUPPLEMENTATION; DRUG BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; LIPOPROTEIN BLOOD LEVEL; MALE; NORMAL HUMAN; OXIDATION; PRIORITY JOURNAL;

ADULT; ARTERIOSCLEROSIS; ASCORBIC ACID; BETA CAROTENE; CAROTENOIDS; DIET; DRUG SYNERGISM; HUMAN; KINETICS; LIPID PEROXIDATION; LIPOPROTEINS, LDL; MALE; MIDDLE AGE; OXIDATION-REDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; THIOBARBITURIC ACID REACTIVE SUBSTANCES; VITAMIN E;

EID: 0027369356     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.88.6.2780     Document Type: Article

References (44)

1. Witztum JI, Steinberg D. Role of oxidized low density lipoprotein in atherogenesis. J Clin Invest. 1991;88:1785-1792.
2. Morel DW, Hessler JR, Chisolm GM. Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid. J Lipid Res. 1983;24:1070-1076.
3. Quinn MT, Parthasarathy S, Fong LG, Steinberg D. Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte macrophages during atherogenesis. Proc Natl Acad Sci U S A. 1987;84:2995-2998.
4. Henriksen T, Mahoney EM, Steinberg D. Enhanced macrophage degradation of biologically modified low density lipoprotein. Arteriosclerosis. 1983;3:149-159.
5. Haberland ME, Fong D, Cheng L. Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits. Science. 1988;241:215-218.
6. Palinski W, Rosenfeld M, Yla-Herttuala S, Gurtner G, Socher S, Butler S, Parthasarathy S, Carew TE, Steinberg D, Witztum J. Low density lipoprotein undergoes oxidative modification in vivo. Proc Natl Acad Sci U S A. 1989;86:1372-1376.
7. Yla-Herttuala S, Palinski W, Rosenfeld M, Parthasarathy S, Carew TE, Butler S, Witztum J, Steinberg D. Evidence for the presence of oxidatively modified LDL in atherosclerotic lesions of rabbit and man. J Clin Invest. 1989;284:1086-1095.
8. Salonen JT, Yla-Herttuala S, Yamamoto R, Butler S, Korpela H, Salonen R, Nyyssonen K, Palinski W, Witztum J. Antibodies against oxidized LDL and progression of carotid atherosclerosis. Lancet. 1992;339:883-887.
9. Kita T, Nagano Y, Yolode M, Ishii K, Kume N, Ooshima A, Yoshida H, Kawai C. Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia. Proc Natl Acad Sci U S A. 1987;84:5928-5931.
10. Carew TE, Schwenke D, Steinberg D. Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effects. Proc Natl Acad Sci U S A. 1987;84:7725-7729.
11. Bjorkhem I, Henricksson-Freyschuss A, Breuer O, Diczfaiusy V, Berglund L, Henrikson P. The antioxidant butylated hydroxytoluene protects against atherosclerosis. Arterioscler Thromb. 1991; 11:15-22.
12. 1-diphenyl-phenylenediamine. J Clin Invest. 1992; 89:1885-1891.
13. Jialal I, Grundy SM. Influence of antioxidant vitamins on LDL oxidation. Ann N Y Acad Sci. 1992;669:237-248.
14. Jialal I, Scaccini C. Antioxidants and atherosclerosis. Current Opin Lipidology. 1992;3:324-328.
15. Jialal I, Vega G, Grundy SM. Physiologic levels of ascorbate inhibit the oxidative modification of LDL. Atherosclerosis. 1990;82: 185-191.
16. Jialal I, Grundy SM. Preservation of the endogenous antioxidants in LDL by ascorbate but not probucol during oxidative modification. J Clin Invest. 1991;87:597-601.
17. Esterbauer H, Striegl G, Puhl H, Rotheneder M. Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Rad Res Commun. 1988;6:67-75.
18. Steinbrecher UP, Parthasarathy S, Leake D, Witztum J, Steinberg D. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of LDL phospholipid. Proc Natl Acad Sci U S A. 1984;81:3883-3887.
19. Jialal I, Norkus EP, Cristol L, Grundy SM. Beta-carotene inhibits the oxidative modification of low-density lipoprotein. Biochim Biophys Acta. 1991;1086:134-138.
20. Harats D, Ben-Naim M, Dabach Y, Hollander G, Havivi E, Stein Y. Effect of vitamin C and E supplementation of susceptibility of plasma lipoproteins to peroxidation induced by acute smoking. Atherosclerosis. 1990;85:47-54.
21. Dieber-Rotheneder M, Puhl H, Waeg G, Esterbauer H. Effect of oral supplementation with D-alpha-tocopherol on the vitamin E of human low density lipoproteins and resistance to oxidation. J Lipid Res. 1991;32:1325-1332.
22. Jialal I, Grundy S. The effect of dietary supplementation with alpha-tocopherol on the oxidative modification of low density lipoprotein. J Lipid Res. 1992;33:899-906.
23. Princen HMG, Van Poppel G, Vogelezang C, Bluytenhak R, Kok FJ. Supplementation with vitamin E but not beta-carotene in vivo protects LDL from lipid peroxidation in vitro. Arterioscler Thromb. 1992;12:554-562.
24. Reaven PD, Khouw A, Beltz WF, Parthasarathy S, Witztum JL. Effect of dietary antioxidant combinations in humans. Arterioscler Thromb. 1993;13:590-600.
25. Lipid Research Clinics Program. Lipid and lipoprotein analysis. In: Manual of Laboratory Operations. Department of Health, Education, and Welfare, National Institutes of Health publication F5-628. 1984.
26. Stacewicz-Sapuntzakis M, Bowen P, Kendall J, Burgess M. Simultaneous determination of serum retinal and various carotenoids. J Micronutr Anal. 1987;3:27-45.
27. Thurnham D, Davies J, Crump B, Situnayake R, Davis M. The use of different lipids to express serum tocopherol: lipid ratios for the measurement of vitamin E status. Ann Clin Biochem. 1986;23: 514-520.
28. Omaye S, Turnbull J, Sauberlich HE. Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids. Methods Enzymol. 1979;62:3-12.
29. Lowry OH, Rosebrough NJ, Farr A, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193: 265-275.
30. Jialal I, Freeman D, Grundy SM. Varying susceptibility of different LDLs to oxidative modification. Arterioscler Thromb. 1991; 11:482-488.
31. Bendich A. Safety issues regarding the use of vitamin supplements. Ann N Y Acad Sci. 1992;669:300-312.
32. Salonen J, Salonen R, Seppanen K, Rinta-Kiikka S, Kuukka M, Korpela H, Alfthan G, Kantola M, Schalch W. Effect of antioxidant supplementation on platelet function. Am J Clin Nutr. 1991;53: 1222-1229.
33. Steinberg D, Workshop Participants. Antioxidants in the prevention of human atherosclerosis. Circulation. 1992;85:2335. Abstract.
34. Costantino JP, Kuller L, Begg L, Redmond C, Bates M. Serum level changes after administration of a pharmacologic dose of beta-carotene. Am J Clin Nutr. 1988;48:1277-1283.
35. Szczeklik A, Gryglewski R, Domagala B, Dwarski R, Basista M. Dietary supplementation with vitamin E in hyperlipoproteinemia. Thromb Haemost. 1985;54:425-430.
36. Navab M, Imes S, Hama S, Hough G, Ross L, Bork R, Valente A, Berliner J, Drinkwater D, Laks H, Fogelman AL. Monocyte transmigration induced by modification of LDL in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein I synthesis and is abolished by HDL. J Clin Invest. 1991; 88:2039-2046.
37. Naruszewicz M, Selinger E, Davignon J. Oxidative modification of lipoprotein (a) and the effect of beta-carotene. Metabolism. 1992; 41:1215-1224.
38. Gaziano JM, Mason JAE, Ridker PM, Buring JE, Hennekens CH. Beta carotene therapy for chronic stable angina. Circulation. 1990; 82(suppl 3):III-201. Abstract.
39. Kagan EV, Serbinoba E, Forte T, Scita G, Packer L. Recycling of vitamin E in human low density lipoproteins. J Lipid Res. 1992;33: 385-397.
40. Bendich A, D'Apolito P, Gabriel E, Machlin LJ. Interaction of dietary vitamin C and vitamin E on guinea pig immune responses to mitogens. J Nutr. 1984;114:1588-1593.
41. Enstrom JE, Kanim LE, Klein MA. Vitamin C intake and mortality among a sample of the United States population. Epidemiology. 1992;3:194-202.
42. Simon JA. Vitamin C and cardiovascular disease: a review. J Am Coll Nutr. 1992;11:107-125.
43. Stampfer MJ, Hennekens CH, Manson JE, Colditz GA, Rosner B, Willett WC. Vitamin E consumption and the risk of coronary disease in women. N Engl J Med. 1993;328:1444-1448.
44. Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med. 1993;328:1450-1456.