Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist

Nature

Volumn 365, Issue 6448, 1993, Pages 759-761

  Clozel, Martine ^a   Breu, Volker ^a   Burri, Kaspar ^a   Cassal, Jean Marie ^a   Fischli, Walter ^a   Gray, Gillian A ^a   Hirth, Georges ^a   Löffier, Bernd Michael ^a   Müller, Marcel ^a   Neidhart, Werner ^a   Ramuz, Henri ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

4 TERT BUTYL N [6 (2 HYDROXYETHOXY) 5 (3 METHOXYPHENOXY) 4 PYRIMIDINYL]BENZENESULFONAMIDE; ENDOTHELIN 1; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; VASOCONSTRICTION;

ADMINISTRATION, ORAL; ANIMAL; ENDOTHELINS; HUMAN; IN VITRO; MALE; MOLECULAR STRUCTURE; MUSCLE CONTRACTION; PYRIMIDINES; RATS; RATS, WISTAR; RECEPTORS, ENDOTHELIN; SULFONAMIDES; VASOCONSTRICTION;

ANIMALIA;

EID: 0027369239     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/365759a0     Document Type: Article

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