Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells

Journal of Clinical Investigation

Volumn 92, Issue 4, 1993, Pages 1866-1874

  Marui, Nobuyuki ^a   Offermann, Margaret K ^a   Swerlick, Robert ^a   Kunsch, Charles ^b   Rosen, Craig A ^b   Ahmad, Mushtaq ^a   Wayne Alexander, R ^a   Medford, Russell M ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOFFMANN LA ROCHE INC   (United States)

Author keywords

Antioxidant; Cell adhesion molecules; Endothelial cells; Nf b; Pyrrolidine dithiocarbamate

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; DOUBLE STRANDED RNA; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; POLYINOSINIC POLYCYTIDYLIC ACID; PYRROLIDINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; ATHEROSCLEROSIS; CELL ADHESION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NORTHERN BLOTTING; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN INDUCTION; TRANSCRIPTION REGULATION; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

ANTIOXIDANTS; BASE SEQUENCE; BINDING SITES; BLOTTING, NORTHERN; CELL ADHESION MOLECULES; CELL NUCLEUS; CELLS, CULTURED; DNA PROBES; E-SELECTIN; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HUMAN; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-1; MOLECULAR SEQUENCE DATA; NF-KAPPA B; OLIGODEOXYRIBONUCLEOTIDES; PROMOTER REGIONS (GENETICS); RECOMBINANT PROTEINS; RNA, MESSENGER; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR; UMBILICAL VEINS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0027365599     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI116778     Document Type: Article

References (7)

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