Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

Cell

Volumn 75, Issue 3, 1993, Pages 451-462

  Smit, J J M ^a   Schinkel, A H ^a   Elferink, R P J Oude ^a   Groen, A K ^a   Wagenaar, E ^a   van Deemter, L ^a   Mol, C A A M ^a   Ottenhoff, R ^a   van der Lugt, N M T ^b   van Roon, M A ^b   van der Valk, M A ^b   Offerhaus, G J A ^b   Berns, A J M ^b   Borst, P ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIA; MURINAE;

CARRIER PROTEIN; GLYCOPROTEIN P; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID;

ANIMAL CELL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; B LYMPHOCYTE; BILE SECRETION; CELL MEMBRANE PERMEABILITY; GENE EXPRESSION; GENE STRUCTURE; GENETIC RECOMBINATION; HEART MUSCLE CELL; HYBRIDIZATION; LIPID METABOLISM; LIVER CELL; LIVER DISEASE; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; NORTHERN BLOTTING; PHOSPHOLIPID BLOOD LEVEL; PRIORITY JOURNAL; RNA ANALYSIS;

ALLELES; ANIMAL; BASE SEQUENCE; BILE; BILIRUBIN; CARRIER PROTEINS; ENZYMES; HOMOZYGOTE; LIVER; LIVER DISEASES; MEMBRANE GLYCOPROTEINS; MICE; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; P-GLYCOPROTEIN; PHOSPHOLIPIDS; RECOMBINATION, GENETIC; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T;

EID: 0027363563     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(93)90380-9     Document Type: Article

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