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Volumn 196, Issue 2, 1993, Pages 576-585

Knocking-Out Concentrations of HIV-1-Specific Inhibitors Completely Suppress HIV-1 Infection and Prevent the Emergence of Drug-Resistant Virus

Author keywords

[No Author keywords available]

Indexed keywords

1 (1H INDOL 2 YLCARBONYL) 4 [3 (ISOPROPYLAMINO)PYRIDINYL]PIPERAZINE; 3 [(4,7 DICHLORO 2 BENZOXAZOLYLMETHYL)AMINO] 5 ETHYL 6 METHYL 2(1H) PYRIDONE; 9 CHLORO 4,5,6,7 TETRAHYDRO 5 METHYL 6 (3 METHYL 2 BUTENYL)IMIDAZO[4,5,1 JK][1,4]BENZODIAZEPINE 2(1H) THIONE; ADEFOVIR; ANTIVIRUS AGENT; DIDANOSINE; L 697 661; NEVIRAPINE; NUCLEOSIDE DERIVATIVE; PYRIDINONE; UNCLASSIFIED DRUG; ZALCITABINE; ZIDOVUDINE;

EID: 0027363224     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1006/viro.1993.1513     Document Type: Article
Times cited : (75)

References (42)
  • 2
    • 0024592935 scopus 로고
    • Differential patterns of intracellular metabolism of 2’, 3’-didehydro-2’, 3-dideox-ythymidine (D4T) and 3’-azido-2’, 3’-dideoxythymidine (AZT), two potent anti-HIV compounds
    • Balzarini, J., Herdewijn, P., and De Clercq, E. (1989). Differential patterns of intracellular metabolism of 2’, 3’-didehydro-2’, 3-dideox-ythymidine (D4T) and 3’-azido-2’, 3’-dideoxythymidine (AZT), two potent anti-HIV compounds. J. Biol, Chem. 264, 6127-6133.
    • (1989) J. Biol, Chem , vol.264 , pp. 6127-6133
    • Balzarini, J.1    Herdewijn, P.2    De Clercq, E.3
  • 3
    • 0026020310 scopus 로고
    • Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyf)adenine, a potent anti-hu-man immunodeficiency virus compound
    • Balzarini, J., Hao, Z., Herdewijn, P., Johns, D. G., and De Clercq, E. (1991). Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyf)adenine, a potent anti-hu-man immunodeficiency virus compound. Proc. Natl. Acad. Set. USA 88, 1499-1503.
    • (1991) Proc. Natl. Acad. Set. USA , vol.88 , pp. 1499-1503
    • Balzarini, J.1    Hao, Z.2    Herdewijn, P.3    Johns, D.G.4    De Clercq, E.5
  • 4
    • 0026606044 scopus 로고
    • 2’, 5’-Bis-O-(Tert-butyldimethylsilyl)-3’-spiro-5”-(4”-amino-r, 2*-oxathiole-2”, 2”-dioxide)pyrimidine (TSAO) nucleoside analogues: Highly selective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcriptase
    • Balzarini, J., Pérez-Pérez, M.-J., San-Félix, A., Schols, D., Perno, C.-F., Vandamme, A.-M., Camarasa, M.-j., and De Clercq, E. (1992a). 2’, 5’-Bis-O-(tert-butyldimethylsilyl)-3’-spiro-5”-(4”-amino-r, 2*-oxathiole-2”, 2”-dioxide)pyrimidine (TSAO) nucleoside analogues: Highly selective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcriptase. Proc. Natl. Acad, Sei. USA 89, 4392-4396.
    • (1992) Proc. Natl. Acad, Sei. USA , vol.89 , pp. 4392-4396
    • Balzarini, J.1    Pérez-Pérez, M.-J.2    San-Félix, A.3    Schols, D.4    Perno, C.-F.5    Vandamme, A.-M.6    Camarasa, M.-J.7    De Clercq, E.8
  • 5
    • 0026694001 scopus 로고
    • [2’, 5’-Bis-O-(Tert-butyldi-methylsilyl)]-3’-spiro-5”-(4”-amino-1”, 2”-oxathiole-2”, 2”-dioxide) (TSAO) derivatives of purine and pyrimidine nucleosides as potent and selective inhibitors of human immunodeficiency virus type
    • Balzarini, J., Pérez-Pérez, M.-J., San-Félix, A., Velazquez, S., Camarasa, M.-J., and De Clercq, E. (1992b). [2’, 5’-Bis-O-(tert-butyldi-methylsilyl)]-3’-spiro-5”-(4”-amino-1”, 2”-oxathiole-2”, 2”-dioxide) (TSAO) derivatives of purine and pyrimidine nucleosides as potent and selective inhibitors of human immunodeficiency virus type 1. Antimicrob. Agents Chemother. 36, 1073-1080.
    • (1992) Antimicrob. Agents Chemother , vol.36 , pp. 1073-1080
    • Balzarini, J.1    Pérez-Pérez, M.-J.2    San-Félix, A.3    Velazquez, S.4    Camarasa, M.-J.5    De Clercq, E.6
  • 6
    • 85027643672 scopus 로고
    • Emergence of drug-resistant human immunodeficiency virus type 1 (HIV-1) mutants following combination of different HIV-1-specific reverse transcriptase inhibitors
    • Balzarini, J., Karlsson, A., Pérez-Pérez, M.-J., Camarasa, M.-J., and De Clercq, E. (1992c). Emergence of drug-resistant human immunodeficiency virus type 1 (HIV-1) mutants following combination of different HIV-1-specific reverse transcriptase inhibitors. Arch. Int. Biochem. Biophys. 101, B2.
    • (1992) Arch. Int. Biochem. Biophys , vol.101 , pp. B2
    • Balzarini, J.1    Karlsson, A.2    Pérez-Pérez, M.-J.3    Camarasa, M.-J.4    De Clercq, E.5
  • 7
    • 0027328082 scopus 로고
    • HIV-1-specific reverse transcriptase inhibitors show differential activity against HIV-1 mutant strains containing different amino acid substitutions in the reverse transcriptase
    • Balzarini, J., Karlsson, A., Pérez-Pérez, M.-J., Vrang, L, Walbers, J., Zhang, H., Öberg, B., Vandamme, A.-M., Camarasa, M.-J., and De Clercq, E. (1993a). HIV-1-specific reverse transcriptase inhibitors show differential activity against HIV-1 mutant strains containing different amino acid substitutions in the reverse transcriptase. Virology 192, 246-253.
    • (1993) Virology , vol.192 , pp. 246-253
    • Balzarini, J.1    Karlsson, A.2    Pérez-Pérez, M.-J.3    Vrang, L.4    Walbers, J.5    Zhang, H.6    Öberg, B.7    Vandamme, A.-M.8    Camarasa, M.-J.9    De Clercq, E.10
  • 8
    • 0027524005 scopus 로고
    • Human immunodeficiency virus type 1-specific (2’, 5’-bis-O-(terf-butyldimethylsilyl)-O-D-ribofuranosyl]-3’-spiro-5”-(4”-amino-r, 2”-oxathiole-2”, 2”-dioxide)-purine analogues show a resistance spectrum that is different from that of the human immunodeficiency virus type 1-specific non-nucleoside analogues
    • Balzarini, J., Velazquez, S., Karlsson, A., Pérez-Pérez, M.-J., San-Félix, A., Camarasa, M.-J., and De Clercq, E. (1993b). Human immunodeficiency virus type 1-specific (2’, 5’-bis-O-(terf-butyldimethylsilyl)-O-D-ribofuranosyl]-3’-spiro-5”-(4”-amino-r, 2”-oxathiole-2”, 2”-dioxide)-purine analogues show a resistance spectrum that is different from that of the human immunodeficiency virus type 1-specific non-nucleoside analogues. Mol. Pharmacol. 43, 109-114.
    • (1993) Mol. Pharmacol , vol.43 , pp. 109-114
    • Balzarini, J.1    Velazquez, S.2    Karlsson, A.3    Pérez-Pérez, M.-J.4    San-Félix, A.5    Camarasa, M.-J.6    De Clercq, E.7
  • 10
    • 0026771409 scopus 로고
    • 3’-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: Synthesis and antiviral activity of [2., 5’-bis-0-(ferf-butyldimethylsilyl)-l8-D-xyiO’ and-ribofuranose]-3’-spiro-5”-[4”-amino-r, 2”-oxathiole-2”, 2”-dioxide] (TSAO) pyrimidine nucleosides
    • Camarasa, M.-J., Pérez-Pérez, M.-J., San-Félix, A., Balzarini, J., and De Clercq, E. (1992). 3’-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2., 5’-bis-0-(ferf-butyldimethylsilyl)-l8-D-xyiO’ and-ribofuranose]-3’-spiro-5”-[4”-amino-r, 2”-oxathiole-2”, 2”-dioxide] (TSAO) pyrimidine nucleosides. J Med. Chem. 35, 2721-2727.
    • (1992) J Med. Chem , vol.35 , pp. 2721-2727
    • Camarasa, M.-J.1    San-Félix, A.2    Balzarini, J.3    De Clercq, E.M.-J.4
  • 13
    • 0026592957 scopus 로고
    • The binding of a novel bis(Heteroaryl)piper-azine mediates inhibition of human immunodeficiency virus type 1 reverse transcriptase
    • Dueweke, T. J., Kezdy, F. J, Waszak, G. A., Deibel, M. R., Jr., and Tarpley, W. G. (1992). The binding of a novel bis(heteroaryl)piper-azine mediates inhibition of human immunodeficiency virus type 1 reverse transcriptase, J. Biol. Chem. 267, 27-30.
    • (1992) J. Biol. Chem , vol.267 , pp. 27-30
    • Dueweke, T.J.1    Kezdy, F.J.2    Waszak, G.A.3    Deibel, M.R.4    Tarpley, W.G.5
  • 17
    • 0026542755 scopus 로고
    • In vitro selection of variants of human immunodeficiency virus type 1 resistant to 3’-azido-3’-deoxythymidine and 2’, 3’-dideoxyinosine
    • Gao, Q., Gu, Z., Parniak, M. A., Li, X., and Wainberg, M. A. (1992). In vitro selection of variants of human immunodeficiency virus type 1 resistant to 3’-azido-3’-deoxythymidine and 2’, 3’-dideoxyinosine. J. Virol 66, 12-19.
    • (1992) J. Virol , vol.66 , pp. 12-19
    • Gao, Q.1    Gu, Z.2    Parniak, M.A.3    Li, X.4    Wainberg, M.A.5
  • 19
    • 0026565278 scopus 로고
    • Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine
    • Kellam, P, Boucher, C. A. B., and Larder, B. A. (1992). Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine. Proc. Natl Acad. Scl USA 89, 1934-1938.
    • (1992) Proc. Natl Acad. Scl USA , vol.89 , pp. 1934-1938
    • Kellam, P.1    Boucher, C.A.B.2    Larder, B.A.3
  • 20
    • 0025788876 scopus 로고
    • Inhibition of human immunodeficiency virus type 1 (HIV-1) replication by the dipyrido-diazepinone BI-RG-587
    • Koup, R. A., Merluzzi, V. J., Hargrave, K. D, Adams, J., Grozinger, K., Eckner, R. J., and Sullivan, J. L. (1991). Inhibition of human immunodeficiency virus type 1 (HIV-1) replication by the dipyrido-diazepinone BI-RG-587. J. Infect. Dis. 163, 966-970.
    • (1991) J. Infect. Dis , vol.163 , pp. 966-970
    • Koup, R.A.1    Merluzzi, V.J.2    Hargrave, K.D.3    Adams, J.4    Grozinger, K.5    Eckner, R.J.6    Sullivan, J.L.7
  • 22
    • 0024310253 scopus 로고
    • Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)
    • Larder, B. A., and Kemp, S. D. (1989). Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT). Science 246, 1155-1158.
    • (1989) Science , vol.246 , pp. 1155-1158
    • Larder, B.A.1    Kemp, S.D.2
  • 23
    • 0024508058 scopus 로고
    • HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy
    • Larder, B. A., Darby, G., and Richman, D. (1989). HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy. Science 243, 1731-1734.
    • (1989) Science , vol.243 , pp. 1731-1734
    • Larder, B.A.1    Darby, G.2    Richman, D.3
  • 25
    • 0026579394 scopus 로고
    • Vitro selection and molecular characterization of human immunodeficiency virus-1 resistant to non-nucleoside inhibitors of reverse transcriptase
    • Mellors, J. W., Dutschman, G. E, Im, G.-J., Tramontano, E, Winkler, S. R, and Cheng, Y.-C. (1992). in vitro selection and molecular characterization of human immunodeficiency virus-1 resistant to non-nucleoside inhibitors of reverse transcriptase. Mol. Pharmacol. 41, 446-451.
    • (1992) Mol. Pharmacol , vol.41 , pp. 446-451
    • Mellors, J.W.1    Dutschman, G.E.2    Im, G.-J.3    Tramontano, E.4    Winkler, S.R.5    Cheng, Y.-C.6
  • 26
    • 0027472841 scopus 로고
    • A single conservative amino acid substitution in the reverse transcriptase of human immunodeficiency virus-1 confers resistance to (+) (5S)-4, 5, 6, 7-tetrahydro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4, 5, 1-jk]-[1, 4]benzodiazepin-2(1H)-thione (TIBO 82150)
    • Mellors, J. W., Im, G.-J., Tramontano, E., Winkler, S. R., Medina, D. J., Dutschman, G. E., Bazmi, H. Z., Piras, G., Gonzalez, C. J., and Cheng, Y.-C. (1993). A single conservative amino acid substitution in the reverse transcriptase of human immunodeficiency virus-1 confers resistance to (+) (5S)-4, 5, 6, 7-tetrahydro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4, 5, 1-jk]-[1, 4]benzodiazepin-2(1H)-thione (TIBO 82150). Mol. Pharmacol. 43, 11-16.
    • (1993) Mol. Pharmacol. , vol.43 , pp. 11-16
    • Mellors, J.W.1    Im, G.-J.2    Tramontano, E.3    Winkler, S.R.4    Medina, D.J.5    Dutschman, G.E.6    Bazmi, H.Z.7    Piras, G.8    Gonzalez, C.J.9    Cheng, Y.-C.10
  • 28
    • 0024408374 scopus 로고
    • A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thy-mine
    • Miyasaka, T., Tanaka, H., Baba, M, Hayakawa, H., Walker, R. T., Balzarini, J, and De Clercq, E. (1989). A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thy-mine. J. Med. Chem. 32, 2507-2509.
    • (1989) J. Med. Chem , vol.32 , pp. 2507-2509
    • Miyasaka, T.1    Tanaka, H.2    Baba, M.3    Hayakawa, H.4    Walker, R.T.5    Balzarini, J.6    De Clercq, E.7
  • 32
    • 0026737678 scopus 로고
    • TSAO Analogues. Stereospecific synthesis and anti-HIV-1 activity of 1-[2’, 5’-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3’-spiro-5’-(4”-amino-1”, 2”-oxathiole-2”, 2”-diox-ide) pyrimidine and pyrimidine-modified nucleosides
    • Pérez-Pérez, M. J., San-Félix, A., Balzarini, J., De Clercq, E., and Camarasa, M. J. (1992). TSAO Analogues. Stereospecific synthesis and anti-HIV-1 activity of 1-[2’, 5’-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3’-spiro-5’-(4”-amino-1”, 2”-oxathiole-2”, 2”-diox-ide) pyrimidine and pyrimidine-modified nucleosides. J. Med. Chem. 35, 2988-2995.
    • (1992) J. Med. Chem , vol.35 , pp. 2988-2995
    • Pérez-Pérez, M.J.1    San-Félix, A.2    Balzarini, J.3    De Clercq, E.4    Camarasa, M.J.5
  • 35
    • 0026318387 scopus 로고
    • Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture
    • Richman, D., Shih, C.-K., Lowy, I., Rose, J., Prodanovich, P, Goff, S., and Griffin, J. (1991). Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture. Proc. Natl. Acad. Sei. USA 88, 11241-11245.
    • (1991) Proc. Natl. Acad. Sei. USA , vol.88 , pp. 11241-11245
    • Richman, D.1    Shih, C.-K.2    Lowy, I.3    Rose, J.4    Prodanovich, P.5    Goff, S.6    Griffin, J.7
  • 36
    • 85027636257 scopus 로고
    • the ACTG 164/168 Study Team, Abstracts of the HIV Drug-Resistance Workshop, Noordwijk, The Netherlands, 16-18 July 1992
    • Richman, D., and the ACTG 164/168 Study Team (1992). The emergence of nevirapine resistance in clinical trials. Abstracts of the HIV Drug-Resistance Workshop, Noordwijk, The Netherlands, 16-18 July 1992, p. 13.
    • (1992) The Emergence of Nevirapine Resistance in Clinical Trials. , pp. 13
    • Richman, D.1
  • 40
    • 0023475103 scopus 로고
    • 3’-Azido-3’-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase. An-timicrob
    • St Clair, M. H., Richards, C. A, Spector, T., Weinhold, K. J., Miller, W. H., Langlais, A. J., and Furman, P. A. (1987). 3’-Azido-3’-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase. An-timicrob. Agents Chemother. 31, 1972-1977.
    • (1987) Agents Chemother , vol.31 , pp. 1972-1977
    • St Clair, M.H.1    Richards, C.A.2    Spector, T.3    Weinhold, K.J.4    Miller, W.H.5    Langlais, A.J.6    Furman, P.A.7


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