Insulin-like growth factor I stimulates lipid oxidation, reduces protein oxidation, and enhances insulin sensitivity in humans

Journal of Clinical Investigation

Volumn 92, Issue 5, 1993, Pages 2249-2256

  Hussain, Mehboob A ^a   Schmitz, Ole ^b   Mengel, Annette ^b   Keller, Annamarie ^a   Christiansen, Jens S ^b   Zapf, Jürgen ^a   Froesch, E Rudolf ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b Department of Medicine II ^*  (Denmark)

Author keywords

Anabolism; Euglycemic clamp; In direct calorimetry; Insulin like growth factor; Substrate oxidation

Indexed keywords

ARGININE; GLUCAGON; GLUCOSE; GROWTH HORMONE; INSULIN; RECOMBINANT SOMATOMEDIN C;

ARTICLE; CALORIMETRY; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; ENERGY EXPENDITURE; FEMALE; GLUCAGON RELEASE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; GROWTH HORMONE RELEASE; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SENSITIVITY; INTRAVENOUS DRUG ADMINISTRATION; LIPID OXIDATION; LIPOLYSIS; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

ADULT; ARGININE; CALORIMETRY; ENERGY METABOLISM; FATTY ACIDS, NONESTERIFIED; FEMALE; GLUCAGON; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; GROWTH HORMONE; HUMAN; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LIPIDS; MALE; OXIDATION-REDUCTION; PROTEINS; RANDOM ALLOCATION; SUPPORT, NON-U.S. GOV'T;

EID: 0027362462     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI116828     Document Type: Article

References (36)

1. Schwander, J. C. C. Hauri, J. Zapf, and E. R. Froesch. 1983. Synthesis and secretion of insulin-like growth factor and its binding protein by the perfused rat liver: dependence on growth hormone status. Endocrinology. 113:297-305.
2. Salmon, W. D., Jr., and W. H. Daughaday. 1957. A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vivo. J. Lab. Clin. Med. 49:825-836.
3. Van-Buul-Offers, S., I. Ueda, and J. L. Van den Brande. 1986. Biosynthetic somatomedin C (SM-C/IGF-1) increases the length and weight of Snell dwarf mice. Pediatr. Res. 20:825-827.
4. Schoenle, E., J. Zapf, R. E. Humbel, and E. R. Froesch. 1982. Insulin-like growth factor I stimulates growth in hypophysectomized rats. Nature (Lond.). 323:169-171.
5. Guler H. P., J. Zapf, E. Scheiwiller, and E. R. Freosch. 1988. Recombinant human insulin like growth factor I stimulates growth and has distinct effects on organ size. Proc. Natl. Acad. Sci. USA. 85:4889-4893.
6. Laron, Z., S. Anin, Y. Klipper-Aurbach, and B. Klinger. 1992. Effects of insulin-like growth factor on linear growth, head circumference, and body fat in patients with Laron-type dwarfism. Lancet. 339:1258-12.
7. Poggi, C., Y. Le Marchand-Brustel, J. Zapf, E. R. Froesch, and P. Freychet. 1979. Effects and binding of insulin-like growth factor in the isolated soleus muscle of lean and obese mice. Endocrinology. 195:732-730.
8. King, G. L., C. R. Kahn, M. M. Rechler, and S. P. Nissley. 1980. Direct demonstration of separate receptors for growth and metabolic activities of insulin and multiplication-stimulating activity (an insulin-like growth factor) using antibodies to the insulin receptor. J. Clin. Invest. 66:130-140.
9. Zapf, J., C. Hauri, M. Waldvogel, and E. R. Froesch. 1986. Acute metabolic effects and half-lives of intravenously administered insulin-like growth factors I and II in normal and hypophysectomized rats. J. Clin. Invest. 77:1768-1775.
10. Guler, H. P., J. Zapf, and E. R. Froesch. 1987. Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults. N. Engl. J. Med. 217:137-140.
11. Boulware, S. D., W. V. Tambourlane, L. S. Mathews, and R. S. Sherwin. 1992. Diverse effects of insulin-like growth factor I on glucose, lipid, and amino acids. Am. J. Physiol. 262:E130-E133.
12. Turkalj, I., U. Keller, R. Ninnis, S. Vosmeer, and W. Stauffacher. 1992. Effect of increasing doses of recombinant human insulin-like growth factor-I on glucose, lipid, and leucine metabolism in man. J. Clin. Endocrinol. Metab. 75:1186-1191.
13. Jacob, R. E., E. Barett, G. Plewe, K. D. Fagin, and R. S. Sherwin. 1989 Acute effects of insulin-like growth factor I on glucose and amino acid metabolism in the awake fasted rat. J. Clin. Invest. 83:1717-1723.
14. Giacca, A., R. Gupta, S. Efendic, K. Hall, A. Skottner, L. Lickely, and M. Vranic. 1990. Differential effects of IGF-I and insulin on glucoregulation and fat metabolism in depancreatized dogs. Diabetes. 39:340-347.
15. Berelowitz, M., M. Szabo, L. A. Frohman, S. Firestone, and L. Chu. 1981. Somatomedin-C mediates growth hormone negative feedback by effects on both hypothalamus and the pituitary. Science (Wash. DC). 212:1279-1281.
16. Guler, H. P., C. Schmid, J. Zapf, and E. R. Froesch. 1989. Effects of recombinant insulin-like growth factor on insulin secretion and renal function in normal human subjects. Proc. Natl. Acad. Sci. USA. 86:2868-2872.
17. Leahy, J. L., and K., M. Vandekerkhove. 1990. Insulin-like growth factor at physiological concentrations is a potent inhibitor of insulin secretion. Endocrinology. 126:1593-1598.
18. Zenobi, P. D., S. Graf, H. Ursprung, and E. R. Froesch. 1992. Effects of insulin-like growth factor-I on glucose tolerance, insulin levels, and insulin secretion. J. Clin. Invest. 89:1908-1913.
19. Zapf, J., E. Schoenle, M. Waldvogel, I. Sand, and E. R. Froesch. 1981. Effect of trypsin treatment of rat adipocytes on biological effects and binding of insulin and insulin-like growth factors: further evidence for the action of insulin-like growth factors through the insulin receptor. Eur. J. Biochem. 113:605-609.
20. Caro, J. F., J. Poulos, O. Ittoop, W. J. Pories, E. G. Flickinger, and M. K. Sinha. 1988. Insulin-like growth factor-I binding in hepatocytes from human liver, human hepatoma, and normal, regenerating, and fetal liver. J. Clin. Invest. 81:976-981.
21. McGuire, E. A. H., J. H. Helderman, J. D. Tobin, R. Andres, and M. Bergman. 1976. Effects of arterial versus venous sampling on analysis of glucose kinetics in man. J. Appl. Physiol. 55:628-634.
22. Segal, K. R., M. Van Loan, P. I. Fitzgerald, J. A. Hodgson, T. B. Van Italie. 1988. Lean body mass estimation by bioelectrical impedance analysis: a four-site cross validation study. Am. J. Clin Nutr. 47:7-14.
23. Christofides, N. D. 1982. Glucagon. In Radioimmunoassay of Gut Regulatory Peptides. S. R. Bloom, and R. G. Long, editors. W. B. Saunders Company. Philadelphia. 74-79.
24. Zapf, J., H. Walter, and E. R. Froesch. 1981. Radioimmunological determination of insulin-like growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia. J. Clin. Invest. 86:952-961.
25. Ciba-Geigy Limited. 1980. Geigy Scientific Charts. Volume 1, 8th edition. Basel. 62-78.
26. 14C glucose. Recent Prog. Horm. Res. 19:445-488.
27. Elia, M., and G. Livesey. 1988. Theory and validity of indirect calorimetry during net lipid synthesis. Am. J. Clin. Nutr. 47:591-607.
28. Cupelli, C., A. Mari, and E. Ferrannini. 1987. Non steady state: Error analysis of Steeles model and development for glucose kinetics. Am. J. Physiol. 252:E679-E89.
29. Wilcoxon, F. 1945. Individual comparisons by ranking methods. Biomed. Bull. 1:80-83.
30. Rennert, N. J., S. Caprio, and R. S. Sherwin. 1993. Insulin-like growth factor I inhibits glucose stimulated insulin secretion but does not impair glucose metabolism in normal humans. J. Clin. Endocrinol. Metab. 76:804-806.
31. Walker, J. L., M. Ginalska-Malinowska, T. E. Romer, J. B. Pucilowska, and L. E. Underwood. 1991. Effects of the infusion of insulin-like growth factor I in a child with growth hormone insensitivity syndrome (Laron dwarfism). N. Engl. J. Med. 324:1483-1488.
32. Bar, R. S., L. C. Harrison, M. Muggeo, P. Gorden, C. R. Kahn, and J. Roth. 1979. Regulation of insulin receptors in normal and abnormal physiology in humans. Adv. Intern. Med. 24:23-52.
33. Rosetti, L., D. Smith, G. I. Shulman., D. Papachristou, and R. A. DeFronzo. 1987. Correction of hyperglycemia with phlorizin nomalizes tissue sensitivity to insulin in diabetic rats. J. Clin. Invest. 79:1510-1515.
34. Moller, N., O. Schmitz, J. O. L. Jorgensen, J. Astrup, J. F. Bak, S. E. Christensen, K. G. M. M. Alberti, and J. Weeke. 1992. Basal- and insulin-stimulated substrate metabolism in patients with active acromegaly before and after adenomectomy. J. Clin. Endocrinol. Metab. 74:1012-1019.
35. Sönksen, P. H., F. C. Greenwood, J. P. Ellis, C. Lowy. A. Rutherford, and J. D. N. Nabarro. 1967. Changes in carbohydrate tolerance in acromegaly with progress of disease and in response to treatment. J. Clin. Endocrinol. 27:1418-1430.
36. Gerich, J. E., M. Lorenzi, D. M. Bier, E. Tsalikian, V. Schneider, J. H. Karam, and P. Forsham. 1976. Effects of physiologic levels of glucagon and growth hormone on human carbohydrate and lipid metabolism: studies involving administration of exogenous hormone during suppression of endogenous hormone secretion with somatostatin. J. Clin. Invest. 57:8745-884.