Factors useful in predicting the response to interferon therapy in chronic hepatitis C

Journal of Gastroenterology and Hepatology

Volumn 8, Issue 6, 1993, Pages 535-539

  TSUBOTA, AKIHITO ^a   CHAYAMA, KAZUAKI ^a   ARASE, YASUJI ^a   KOIDA, ISAO ^a   SAITOH, SATOSHI ^a   IKEDA, KENJI ^a   IWASAKI, SATOMI ^a   MATSUMOTO, TOYOMI ^a   KOBAYASHI, MARIKO ^a   KUMADA, HIROMITSU ^a  

^a TORANOMON HOSPITAL   (Japan)

Author keywords

chronic hepatitis C; hepatitis C virus genotype; interferon therapy; Key words; multivariate analysis.

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA INTERFERON; BETA INTERFERON;

ADULT; AGED; ALOPECIA; ARTICLE; CHRONIC HEPATITIS; CONTROLLED STUDY; DEPRESSION; EYE TOXICITY; FEMALE; HEPATITIS C VIRUS; HUMAN; HYPERTHYROIDISM; INFLUENZA; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; NEPHROTOXICITY; POLYMERASE CHAIN REACTION; PSYCHOSIS; RASH; THROMBOCYTOPENIA;

ADULT; AGED; ALANINE TRANSAMINASE; BASE SEQUENCE; CHRONIC DISEASE; FEMALE; GENOTYPE; HEPACIVIRUS; HEPATITIS C; HUMAN; INTERFERONS; MALE; MIDDLE AGE; MOLECULAR SEQUENCE DATA; MULTIVARIATE ANALYSIS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 0027362398     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.1993.tb01648.x     Document Type: Article

References (24)

1. Treatment of chronic hepatitis C with recombinant interferon alfa. A multicenter, randomized, controlled trial
2. Recombinant interferon alfa therapy for chronic hepatitis C. A randomized, double‐blind, placebo‐controlled trial
3. Randomized, double‐blind, placebo‐controlled, trial of eight week course of recombinant α‐interferon for chronic non‐A, non‐B hepatitis
4. Comparison of 1 of 3 MU of interferon alfa 2b and placebo in patients with chronic non‐A, non‐B hepatitis
5. Interferon therapy for chronic hepatitis C
6. There are two major types of hepatitis C virus in Japan
7. Molecular biology of the hepatitis C viruses: Implication for diagnosis, development and control of viral disease
8. Typing hepatitis C virus by polymerase chain reaction with type‐specific primers: application to clinical surveys and tracing infection sources
9. Acute and chronic hepatitis revisited
10. Effect of interferon administration on serum hepatitis C virus RNA in patients with chronic hepatitis C
11. Detection of hepatitis C virus RNA by a two stage polymerase chain reaction with two pairs of primers deduced from the 5′ noncoding region
12. Genotypic subtyping of hepatitis C virus
13. Simplified method for confirmation of PRC products
14. Avoiding false positives with PCR
15. Quantal response curves for experimentally uncontrolled variables
16. Quantitative analysis of hepatitis C virus RNA by competitive nested polymerase chain reaction
17. Isolation of a cDNA clone derived from a blood‐borne non‐A, non‐B viral hepatitis genome
18. Molecular cloning of the human hepatitis C virus genome from Japanese patients with non‐A, non‐B hepatitis
19. Genetic organization and diversity of the hepatitis C virus
20. Structure and organization of the hepatitis C virus genome isolated from human carriers
21. Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human carrier: comparison with reported isolates for conserved and divergent regions
22. Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: Potential role in chronic HCV infections
23. The degree of variability in the amino terminal region of the E2/NS1 protein of hepatitis C virus correlates with responsiveness to interferon therapy in viremic patients