A New Series of Imidazolones: Highly Specific and Potent Nonpeptide AT1 Angiotensin II Receptor Antagonists

Journal of Medicinal Chemistry

Volumn 36, Issue 22, 1993, Pages 3371-3380

  Bernhart, Claude A ^a   Perreaut, Pierre M ^a   Ferrari, Bernard P ^a   Muneaux, Yvette A ^a   Assens, Jean Louis A ^a   Clément, Jacques ^a   Haudricourt, Frédérique ^a   Muneaux, Claude F ^a   Taillades, Joelle E ^a   Vignal, Marie Aimée ^a   Gougat, Jean ^a   Guiraudou, Pierre R ^a   Lacour, Colette A ^a   Roccon, Alain ^a   Cazaubon, Catherine F ^a   Brelière, Jean Claude ^a   Le Fur, Gérard ^a   Nisato, Dino ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN RECEPTOR; LOSARTAN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; COMPETITIVE INHIBITION; CONGESTIVE HEART FAILURE; DRUG STRUCTURE; DRUG SYNTHESIS; HYPERTENSION; KIDNEY FAILURE; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANGIOTENSIN II; ANIMAL; BIPHENYL COMPOUNDS; FEMALE; IMIDAZOLES; IN VITRO; MACACA FASCICULARIS; MALE; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANGIOTENSIN; SENSITIVITY AND SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES;

EID: 0027361358     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00074a018     Document Type: Article

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