Distinct patterns of expression of fibroblast growth factors and their receptors in human atheroma and nonatherosclerotic arteries association of acidic FGF with plaque microvessels and macrophages

Journal of Clinical Investigation

Volumn 92, Issue 5, 1993, Pages 2408-2418

  Brogi, Edi ^a   Winkles, Jeffrey A ^b   Underwood, Robert ^a   Clinton, Steven K ^c   Alberts, Gregory F ^b   Libby, Peter ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HOLLAND LABORATORY   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Angiogenesis; Atherosclerosis; Basic fibroblast growth factor; Macrophages; Neovascularization

Indexed keywords

ACIDIC FIBROBLAST GROWTH FACTOR; BASIC FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; MESSENGER RNA;

ANGIOGENESIS; ARTICLE; ATHEROGENESIS; ATHEROMA; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MACROPHAGE; NEOVASCULARIZATION (PATHOLOGY); NORTHERN BLOTTING; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

ARTERIES; ARTERIOSCLEROSIS; BASE SEQUENCE; CELLS, CULTURED; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTORS; GROWTH SUBSTANCES; HUMAN; IMMUNOHISTOCHEMISTRY; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; RECEPTORS, FIBROBLAST GROWTH FACTOR; RNA, MESSENGER; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027360010     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI116847     Document Type: Article

References (21)

1. Klagsbrun, M., and E. R. Edelman. 1989. Biological and biochemical properties of fibroblast growth factors. Arteriosclerosis. 9:269-278.
2. Burgess, W. H., and T. Maciag. 1989. The heparin-binding (fibroblast) growth factor family of proteins. Annu. Rev. Biochem. 58:575-606.
3. Goldfarb, M. 1990. The fibroblast growth factor family. Cell Growth & Differ. 1:439-445.
4. Gospodarowicz, D. 1991. Biological activities of fibroblast growth factors. Ann. NY Acad. Sci. 638:1-8.
5. Gospodarowicz, D. 1990. Fibroblast growth factor and its involvement in developmental processes. Curr. Top. Dev. Biol. 24:57-93.
6. Pierce, G. F., J. E. Tarpley, D. Yanagihara, T. A. Mustoe, G. M. Fox, and A. Thomason. 1992. Platelet-derived growth factor (BB homodimer), transforming growth factor-beta 1, and basic fibroblast growth factor in dermal wound healing. Am. J. Pathol. 140:1375-1388.
7. Nabel, E. G., Z. Y. Yang, G. Plautz, R. Forough, X. Zhan, C. C. Haudenschild, T. Maciag, and G. J. Nabel. 1993. Recombinant fibroblast growth factor-1 promotes intimal hyperplasia and angiogenesis in arteries in vivo. Nature (Lond.). 362:844-846.
8. Baird, A., and M. Klagsbrun. 1991. Nomenclature meeting. Report and recommendations. Ann. NY Acad. Sciences. 638:xiii-xvi.
9. Jaye, M., J. Schlessinger, and C. A. Dionne. 1992. Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction. Biochim. Biophys. Acta. 1135:185-199.
10. Givol, D., and Y. Avner. 1992. Complexity of FGF receptors: genetic basis for structural diversity and functional specificity. FASEB (Fed. Am. Soc. Exp. Biol.) J. 6:3362-3369.
11. Lindner, V., R. A. Majack, and M. A. Reidy. 1990. Basic fibroblast growth factor stimulated endothelial regrowth and proliferation in denuded arteries. J. Clin. Invest. 85:2004-2008.
12. Bjornsson, T. D., M. Dryjski, J. Tluczek, R. Mennie, J. Ronan, T. N. Mellin, and K. A. Thomas. Acidic fibroblast growth factor promotes vascular repair. Proc. Natl. Acad. Sci. USA. 88:8651-8655.
13. Lindner, V., D. A. Lappi, A. Baird, R. A. Majack, and M. A. Reidy. 1991. Role of basic fibroblast growth factor in vascular lesion formation. Circ. Res. 68:106-113.
14. Edelman, E. R., M. A. Nugent, L. T. Smith, and M. J. Karnovsky. 1992. Basic fibroblast growth factor enhances the coupling of intimal hyperplasia and proliferation of vasa vasorum in injured rat. J. Clin. Invest. 89:465-473.
15. Cordon-Cardo, C., I. Vlodavsky, A. Haimovitz-Friedman, D. Hiclin, and Z. Fuks. 1990. Expression of basic fibroblast growth factor in normal human tissues. Lab. Invest. 63:832-840.
16. Healy, A. M., and I. M. Herman. 1992. Density dependent accumulation of basic fibroblast growth factor in the subendothelial matrix. Eur. J. Cell. Biol. 59:56-67.
17. Winkles, J. A., and C. G. Gay. 1991. Serum, phorbol ester, and polypeptide mitogens increase class 1 and 2 heparin binding (acidic and basic fibroblast growth factor) gene expression in human vascular smooth muscle cells. Cell Growth & Differ. 2:531-540.
18. Winkles, J. A., K. A. Peifley, and R. E. Friesel. 1992. Tumor promoters induce basic fibroblast growth factor gene expression in human dermal fibroblasts. Cancer Res. 52:1040-1043.
19. Tsuchiya, S., Y. Kobayashi, Y. Goto, H. Okumura, S. Nakac, T. Konno, and K. Tada. 1982. Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester. Cancer Res. 42:1530-1536.
20. Libby, P., and K. V. O'Brien. 1983. Culture of quiescent vascular smooth muscle cells in a defined serum-free medium. J. Cell. Physiol. 115:217-223.
21. Chirgwin, J. M., A. E. Pryzbyla, R. J. Macdonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 18:5294-5299.