Insecticide action at the GABA‐gated chloride channel: Recognition, progress, and prospects

Archives of Insect Biochemistry and Physiology

Volumn 22, Issue 1-2, 1993, Pages 13-23

  Casida, John E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

chloride channel; cyclodienes; dithianes; GABA receptor; insecticides; lindane; toxaphene; trioxabicyclooctanes

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; CHLORIDE; INSECTICIDE; MEMBRANE PROTEIN;

ANIMAL; CHANNEL GATING; CHLORIDE CHANNEL; DRUG EFFECT; ION CHANNEL; METABOLISM; PHYSIOLOGY; REVIEW;

ANIMAL; CHLORIDE CHANNELS; CHLORIDES; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; INSECTICIDES; ION CHANNEL GATING; ION CHANNELS; MEMBRANE PROTEINS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027344016     PISSN: 07394462     EISSN: 15206327     Source Type: Journal    
DOI: 10.1002/arch.940220104     Document Type: Article

References (46)

1. Anamirta paniculata
2. A study of the action of picrotoxin on the inhibitory neuromuscular junction of the crayfish
3. A receptor shows a lignand‐gated receptor super‐family
4. A receptors
5. A receptorchloride ion channel complex
6. Picrotoxinin binding as a probe of the GABA postsynaptic membrane receptor‐ionophore complex
7. Toxaphene components and related compounds: Preparation and toxicity of some hepta‐, octa‐, and nonachlorobornanes, and a hexachlorobornadiene
8. Evidence for similarities between cyclodiene‐type insecticides and picrotoxinin in their action mechanisms
9. Interactions of lindane, toxaphene and cyclodienes with brain‐specifict‐butylbicyclophosphorothionate receptor
10. Noncompetitive inhibition of GABA receptors in insect and vertebrate CNS by endrin and lindane
11. The subacute inhalation toxicity of 109 industrial chemicals
12. Bicyclic phosphorus esters: High toxicity without cholinesterase inhibition
13. Structure‐toxicity relationships of 2,6,7‐trioxabicyclo[2.2.2]octanes and related compounds
14. Bicyclic phosphorus esters that are potent convulsants and GABA antagonists
15. Hazardous caged phosphorus compounds
16. Extreme toxicity from combustion products of a fire‐retarded polyurethane foam
17. Production of a bicyclophosphate neurotoxic agent during pyrolysis of synthetic lubricant oil
18. 35S] t‐Butylbicyclophosphorothionate binds with high affinity to brain‐specific sites coupled to γ‐aminobutyric acid‐A and ion recognition sites
19. Neurotoxic insecticides inhibit GABA‐dependent chloride uptake by mouse brain vesicles
20. Modulation of γ‐aminobutyric acid‐stimulated chloride influx by bicycloorthocarboxylates, bicyclophosphorus esters, polychlorocycloalkanes and other cage convulsants
21. A receptor antagonists
22. Trioxabicyclooctanes as probes for the convulsant site of the GABA‐gated chloride channel in mammals and arthropods
23. Structure‐toxicity relationships of 1‐substituted‐4‐alkyl‐2,6,7‐trioxabicyclo[2.2.2]octanes
24. 1,4‐Disubstituted 2,6,7‐trioxabicyclo[2.2.2]octanes: A new class of insecticides
25. 3H]Butylbicycloorthobenzoate: New radioligand probe for the γ‐aminobutyric acid‐regulated chloride ionophore
26. 3H]Butyl‐1‐(4‐cyanophenyl)‐2,6,7‐trioxabicyclo[2.2.2]octane: Specific binding in the cockroach central nervous system
27. 2]propyl‐2,6,7‐trioxabicyclo[2.2.2]octane
28. House fly brain GABA‐gated chloride channel: Target for multiple classes of insecticides
29. 1‐(4‐Ethynylphenyl)‐2,6,7‐trioxabicyclo[2.2.2]‐octanes: A new order of potency for insecticides acting at the GABA‐gated chloride channel
30. A receptor antagonist
31. 1‐[4‐[(Trimethylsilyl)ethynyl]phenyl]‐2,6,7‐trioxabicyclo[2.2.2]octanes: A novel type of selective proinsecticide
32. Silylated 1‐(4‐ethynylphenyl)‐2,6,7‐trioxabicyclo[2.2.2]octanes: Structural features and mechanisms of proinsecticidal action and selective toxicity
33. Structure‐biodegradability relationships of insecticidal 1,4‐disubstituted‐2,6,7‐trioxabicyclo[2.2.2]octanes
34. Insecticidal 1,3‐dithianes
35. 2‐Aryl‐5‐tert‐butyl‐1,3‐dithianes and their S‐oxidation products: Structure‐activity relationships of potent insecticides acting at the GABA‐gated chloride channel
36. Biological activity of silatranes
37. 4‐Alkynylphenylsilatranes: Insecticidal activity, mammalian toxicity, and mode of action
38. Spirosultam LY219048, a new chemical class of neurotoxin acting upon the GABA receptor/chloride ionophore complex
39. 23‐Oxo(keto) and 23‐imino derivatives of LL‐F28249 compounds with pesticide activity. European Patent Application EP 259,779 16 March
40. Avermectin binding in Caenorhabditis elegans. A two‐state model for the avermectin binding site
41. 35S] t‐butylbicyclophosphorothionate receptor and coupled components of the GABA receptor‐ionophore complex in brains of human, cow, rat, chicken and fish
42. Ivermectin‐stimulated release of neurotransmitter in the insect central nervous system: Modulation by external chloride and inhibition by a novel trioxabicyclooctane and two polychlorocycloalkane insecticides
43. Two types of cage convulsant action at the GABA‐gated chloride channel