Herbimycin A, a pp60c-src tyrosine kinase inhibitor, inhibits osteoclastic bone resorption in vitro and hypercalcemia in vivo

Journal of Clinical Investigation

Volumn 91, Issue 6, 1993, Pages 2791-2795

  Yoneda, Toshiyuki ^a   Lowe, Carolyn ^a   Lee, Chang Ho ^a   Gutierrez, Gloria ^a   Niewolna, Maria ^a   Williams, Paul J ^a   Izbicka, Elzbieta ^a   Uehara, Yosimasa ^b   Mundy, Gregory R ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

Bone resorption; Hypercalcemia; Osteoclast; Ppo60c src; Tyrosine kinase inhibitors

Indexed keywords

HERBIMYCIN A; PROTEIN TYROSINE KINASE; RECOMBINANT INTERLEUKIN 1ALPHA; HERBIMYCIN; PROTEIN TYROSINE KINASE C SRC; PROTEIN-TYROSINE KINASE C-SRC; QUINONE DERIVATIVE;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CALCIUM BLOOD LEVEL; CYTOLYSIS; GENE EXPRESSION; HYPERCALCEMIA; MOUSE; NONHUMAN; ORGAN CULTURE; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTO ONCOGENE; SIGNAL TRANSDUCTION; ANIMAL; BLOOD; BONE; BONE MARROW; CELL CULTURE; DRUG EFFECT; METABOLISM; RAT;

ANIMAL; BONE AND BONES; BONE MARROW; BONE RESORPTION; CELLS, CULTURED; HYPERCALCEMIA; MICE; OSTEOCLASTS; PROTEIN-TYROSINE KINASE; QUINONES; RATS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027336839     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI116521     Document Type: Article

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