Response of radiation-sensitive human cells to defined DNA breaks

International Journal of Radiation Biology

Volumn 64, Issue 5, 1993, Pages 523-529

  Costa, N D ^a   Thacker, J ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

RESTRICTION ENDONUCLEASE;

ARTICLE; ATAXIA TELANGIECTASIA; BLOOM SYNDROME; CONTROLLED STUDY; DNA STRAND BREAKAGE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RADIOSENSITIVITY; X RAY;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ATAXIA TELANGIECTASIA; BLOOM SYNDROME; CELL LINE; DNA DAMAGE; DNA RESTRICTION ENZYMES; HUMAN; IN VITRO; RADIATION TOLERANCE; SUPPORT, NON-U.S. GOV'T;

EID: 0027333292     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/09553009314551731     Document Type: Letter

References (39)

1. Comparative human cellular radiosensitivity: I. The effect of SV40 transformation and immortalisation on the gamma-irradiation survival of skin derived fibroblasts from normal individuals and from ataxia-telangiectasia patients and heterozygotes
2. Survey of radiosensitivity in a variety of human cell strains
3. Different substrates specificities of the two DNA ligases of mammalian cells
4. Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents
5. A model for restriction fragment length distributions
6. Enzymatic restriction of mammalian cell DNA: evidence for double-strand breaks as potentially lethal lesions
7. High chromosomal sensitivity of Chinese hamster xrs5 cells to restriction endonuclease induced double-strand breaks
8. Differences in accumulation of blunt- and cohesive-ended double-strand breaks generated by restriction endonucleases in electroporated CHO cells
9. Elevated levels of DNA double-strand breaks (dsb) in restriction endonuclease-treated xrs5 cells correlate with reduced capacity to repair dsb
10. The effectiveness of restriction endonucleases in cell killing and mutation
11. Ataxia-telangiectasia: a human mutation giving high frequency of misrepair of DNA double-stranded scissions
12. Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains
13. Properties of a deoxyribonucleic acid ligase mutant of Escherichia coli: X-ray sensitivity
14. Restriction endonuclease/nick translation of fixed mouse chromosomes: a study of factors affecting digestion of chromosomal DNA in situ
15. Inherent cellular radiosensitivity as a basic concept for human tumor therapy
16. Interpretation of the shape of survival curves in terms of induction and repair/misrepair of DNA double-strand breaks
17. Repair and misrepair of site-specific DNA double-strand breaks by human cell extracts
18. Increased sensitivity to killing by restriction enzymes in the XR-1 DNA double-strand break repair-deficient mutant
19. Cell cycle-dependent repair of double-strand DNA breaks in a γ-ray-sensitive Chinese hamster cell
20. Repair of the Escherichia coli chromosome after in vivo scission by Eco RI endonuclease
21. The combination of DNA methylation and H1 histone binding inhibits the action of a restriction endonuclease on plasmid DNA
22. Limited and unlimited growth of SV40-transformed cells from human diploid MRC-5 fibroblasts
23. The DNA repair capability of cdc9, the Saccharomyces cerevisiae mutant defective in DNA ligase
24. X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining
25. 2 on Bloom's syndrome and normal chromosomes
26. Relation between the human fibroblast strain 46BR and cell lines representative of Bloom's syndrome
27. Ataxia-telangiectasia: an inherited disorder of ionizing-radiation sensitivity in man
28. Ligase-deficient yeast cells exhibit defective DNA rejoining and enhanced gamma-ray sensitivity
29. Chromosomal aberration induction in CHO cells by combined exposure to restriction enzymes and X-rays
30. Molecular and biochemical aspects of Bloom's syndrome
31. The rejoining of double-strand breaks in DNA by human cell extracts
32. 2 phase X-irradiation of cells from cancer-prone individuals implicates deficiency in DNA repair
33. A wild-type DNA ligase I gene is expressed in Bloom's syndrome cells
34. Camptothecin cytotoxicity in mammalian cells is associated with the induction of persistent double-strand breaks in replicating DNA
35. Normal DNA ligase activity in a γ-ray-sensitive Chinese hamster mutant
36. Three distinct DNA ligases in mammalian cells
37. A new syndrome of immunodeficiency and increased cellular sensitivity to DNA damaging agents
38. X-ray sensitivity of fifty-three human diploid fibroblast cell strains from patients with characterized genetic disorder
39. DNA ligase I deficiency in Bloom's syndrome