EICAR (5-ethynyl-1-β-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis

Journal of Biological Chemistry

Volumn 268, Issue 33, 1993, Pages 24591-24598

  Balzarini, J ^a   Karlsson, A ^a   Wang, L ^a   Bohman, C ^a   Horska, K ^a   Votruba, I ^a   Fridland, A ^a   Van Aerschot, A ^a   Herdewijn, P ^a   De Clercq, E ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

5 ETHYNYL 4 IMIDAZOLECARBOXAMIDE 1 RIBOSIDE; ADENOSINE KINASE; DEOXYCYTIDINE KINASE; DEOXYGUANOSINE; GUANOSINE PHOSPHATE; INOSINATE DEHYDROGENASE; MYCOPHENOLIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASE; NUCLEOTIDASE; RIBAVIRIN; TIAZOFURIN; TUBERCIDIN;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CELL FREE SYSTEM; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSTASIS; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME LOCALIZATION; ENZYME PURIFICATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE; ANIMAL; ANTINEOPLASTIC AGENTS; CELL DIVISION; DEOXYGUANINE NUCLEOTIDES; GUANINE; GUANOSINE; GUANOSINE TRIPHOSPHATE; HUMAN; IMP DEHYDROGENASE; LEUKEMIA L1210; LYMPHOCYTES; MICE; MYCOPHENOLIC ACID; PURINE NUCLEOTIDES; RIBAVIRIN; RIBONUCLEOSIDES; RIBONUCLEOTIDES; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED;

MURINAE;

EID: 0027331494     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (0)