3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically Active Anticonvulsants Acting by Antagonism at the Glycine Site of the N-Methyl-d-Aspartate Receptor Complex

Journal of Medicinal Chemistry

Volumn 36, Issue 22, 1993, Pages 3386-3396

  Rowley, Michael ^a   Leeson, Paul D ^a   Stevenson, Graeme I ^a   Moseley, Angela M ^a   Stansfield, Ian ^a   Sanderson, Ian ^a   Robinson, Lesley ^a   Baker, Raymond ^a   Kemp, John A ^a   Marshall, George R ^a   Foster, Alan C ^a   Grimwood, Sarah ^a   Tricklebank, Mark D ^a   Saywell, Kay L ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5,7 DICHLORO 1,2,3,4 TETRAHYDRO 4 (3 PHENYLUREIDO) 2 QUINOLINECARBOXYLIC ACID; 7 CHLORO 3 (CYCLOPROPYLCARBONYL) 4 HYDROXY 2(1H) QUINOLONE; 7 CHLORO 4 HYDROXY 2(1H) OXO 3 QUINOLINECARBOXYLIC ACID 3 (3 HYDROXYPHENYL) 2 PROPYNYL ESTER; DRUG CARRIER; EXCITATORY AMINO ACID RECEPTOR; GLYCINE; L 701252; L 701273; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTICONVULSANT ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; BRAIN ISCHEMIA; CELL INTERACTION; DRUG ANTAGONISM; DRUG SYNTHESIS; EPILEPSY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PRIORITY JOURNAL;

ACYLATION; ANIMAL; ANTICONVULSANTS; BINDING SITES; CEREBRAL CORTEX; GLYCINE; HYDROXYQUINOLINES; KETONES; KINETICS; LACTAMS; RATS; RATS, INBRED STRAINS; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0027331480     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00074a020     Document Type: Article

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