Conjugate of mitomycin C with N-succinyl-chitosan: In vitro drug release properties, toxicity and antitumor activity

International Journal of Pharmaceutics

Volumn 98, Issue 1-3, 1993, Pages 121-130

  Song, Youhua ^a   Onishi, Hiraku ^a   Nagai, Tsuneji ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Acute toxicity; Antitumor activity; Conjugate; Drug regeneration rate; Mitomycin C; N Succinyl chitosan; P388 leukemia; Treatment schedule

Indexed keywords

CHITOSAN; CHITOSAN DERIVATIVE; MITOMYCIN C; SUCCINIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKEMIA P 388 CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0027328969     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(93)90048-K     Document Type: Article

References (19)

1. In vitro evaluation of immunoconjugates prepared by linking mitomycin C to monoclonal antibodies via a polyglutamic acid carriers
2. Targeting of drugs
3. Antitumor activity of mitomycin C-dextran conjugate against various murine tumors
4. Regeneration characteristics of mitomycin C-dextran conjugate in relation to its activity
5. Preaparation and properties of a mitomycin C-albumin conjugtate
6. Physico-chemical and antitumor characteristics of high molecular weight prodrugs of mitomycin C
7. Enhanced antitumor activity of mitomycin C conjugated with anti-α-fetoprotein antibody by a novel method of conjugation
8. Mitomycin C-dextran conjugate: a novel high molecular weight pro-drug of mitomycin C
9. Plasma disposition and in vivo and in vitro antitumor activities of mitomycin C-dextran conjugate in relation to the mode of action
10. Cellular interaction and in vitro antitumor of mitomycin C-dextran conjugate
11. Physicochemical and antitumor characteristics of some polyamino acid prodrugs of mitomycin C
12. Synthesis and drug-release characteristics of the conjugates of mitomycin C with N-succinyl-chitosan and carboxymethyl-chitin
13. Enhanced lymphatic delivery of mitomycin C conjugated with dextran
14. Wirksamkeits- und Konzentrationsbestimmung durch Tierversuche
15. Magnetically resposive microspheres and other carriers for the biophysical targeting of antitumor agents
16. Binding of anticancer drugs to carrier molecules