Interferon-α (IFNα) induces a cytolytic mechanism in ovarian carcinoma cells through a protein kinase C-dependent pathway

Gynecologic Oncology

Volumn 50, Issue 2, 1993, Pages 208-214

  Powell, C Bethan ^a   Manning, Kathleen ^a   Collins, John Leslie ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0027320943     PISSN: 00908258     EISSN: None     Source Type: Journal    
DOI: 10.1006/gyno.1993.1194     Document Type: Article

References (25)

1. Balkwill, F. R. The regulatory role of interferons in the human immune response, in Interferons: Their impact in biology and medicine (J. Taylor-Papadimitriou, Ed.), Oxford Univ. Press, Oxford, pp. 61-80 (1985).
2. Taylor-Papadimitriou, J., and Rozengurt, E. Interferons as regulators of cell growth and differentiation, in Interferons: Their impact in biology and medicine (J. Taylor-Papadimitriou, Ed.), Oxford Univ. Press, Oxford, pp. 81-98 (1985).
3. Clemens, M. J., and Mc Nurlan, M. A. Regulation of cell proliferation and differentiation by interferons, Biochem. J. 226, 345-360 (1985).
4. Powell, C. B., Horuchi, T., Kao, M-S., and Collins, J. L. Inter-feron-a (IFNa) activates a lytic mechanism in ovarian and cervical carcinoma cells, Am. J. Obstet. Gynecol, in press (1993).
5. Pestka, S., Langer, J. A., Zoon, K. C., and Samuel, C. E. Interferons and their actions, Annu. Rev. Biochem. 56, 727-777 (1987).
6. Yonehara, S., Ishii, A., and Yonehara-Takahashi, M. Cell surface receptor-mediated internalization of interferon: Its relation to the antiviral activity of interferon, J. Gen. Virol. 64, 2409-2418 (1983).
7. Smith, M. R., Young, H. A., Kung, H-F., and Duran, S. K. Intracellular activities of microinjected cytokines and lymphokines, in The cellular basis of immune modulation (J. G. Kaplan, D. R. Green, and R. C. Bleackley, Eds.), A. R. Liss, New York, pp. 261-264 (1989).
8. Sanceau, J., Sondermeyer, P., Beranger, F., Falcoff, R., and Vaquero, C. Intracellular human gamma-interferon triggers an antiviral state in transformed murine L cells, Proc. Natl. Acad. Sci. U.S.A. 84, 2906-2910 (1987).
9. Yap, W. H., Teo, T. S., and Tan, Y. H. An early event in the interferon induced transmembrane signaling process, Science 234, 355-358 (1986).
10. Cernescu, C., Constantinescu, S. N., Balta, F., Popescu, L. M., and Cajal, N. Interferon-induced antiviral state is inhibited by neomycin and mimicked by diacylglycerols, Biochem. Biophys. Res. Commun. 151, 402-407 (1988).
11. Reich, N. C., and Pfeffer, L. M. Evidence for involvement of protein kinase C in the cellular response to interferon-a, Proc. Natl. Acad. Sci'1 U.S.A. 87, 8761-8765 (1990).
12. Exley, R., Gordon, J., and Clemens, M. J. Induction of B-cell differentiation antigens in interferon or phorbol ester-treated Daudi cells is impaired by inhibitors of ADP-ribosyltransferase, Proc. Natl. Acad. Sci. U.S.A. 84, 6467-6470 (1987).
13. Massad, li S., Mutch, D. G., Powell, C. B., Kao, M-S., and Collins, J. L. Expression of a resistance mechanism in ovarian and cervical carcinoma cells prevents their lysis by interferon-", Cancer Res. 50, 4923-4928 (1990).
14. Bishop, Y. M. M., Fienberg, S. E., and Holland, P. W. Discrete multivariant analysis, MIT Press, Boston (1975).
15. Csermely, P., Balint, E., Grimley, P. M., and Aszalos, A. Protein kinase C is involved in the early signals of interferon-" but not of interferon-y in U937 cells, J. Interferon Res. 10, 605-611 (1990).
16. Constantinescu, S. N., Cemescu, C., Balta, F., Maniu, H., and Popescu, L. M. The priming effect of human interferon is mediated by protein kinase C, J. Interferon Res. 10, 589-597 (1990).
17. Politis, A. D., and Vogel, S. N. Pharmacologic evidence for the requirement of protein kinase C in IFN-induced macrophage Fc gamma receptor and la antigen expression, J. Immunol. 145, 3788-3795 (1990).
18. Cernescu, C., Constantinescu, S. N., Balta, F., Popescu, L, M., and Cajal, N. Protein kinase C and the antiviral effect of human interferon, Virologie 40, 163-170 (1989).
19. Castagna, M., Takai, Y., Kaibuchi, K., Sano, K., Kikkawa, U., and Nishizuka, Y. Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-producing phorbol esters, J. Biol. Chem. 257, 7847-7851 (1982).
20. Hovis, J. G., Stumpo, D. J., Halsey, D. L., and Blackshear, P. J. Effect of mitogens on ornithine decarboxylase activity and messenger RNA levels in normal and protein kinase C-deficient NIH-3T3 fibroblasts, J. Biol. Chem. 261, 10380-10386 (1986).
21. Mond, J. J., Feuerstein, N., June, C. H., Balapure, A. K., Glazer, R. I., Witherspoon, K., and Brunswick, M. Bimodal effect of phorbol ester on B cell activation, J. Biol. Chem. 266, 4458-4463 (1991).
22. Hidaka, H., Inagaki, M., Kawamoto, S., and Sasaki, Y, Isoquin-olinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C, Biochemistry 23, 5036-5041 (1984).
23. Spacey, G. D., Bonser, R. W., Randall, R. W., and Garland, L. G. Selectivity of protein kinase inhibitors in human intact platelets. Cell. Signaling 2, 329-338 (1990).
24. Butler, A. P., Mar, P. K., Mc Donald, F. F., and Ramsay, R. L. Involvement of protein kinase C in the regulation of ornithine decarboxylase m RNA by phorbol esters in rat hepatoma cells. Exp. Cell Res. 194, 56-61 (1991).
25. Davis, B. D., Dulbecco, R., Eisen, H. N., Ginsberg, H. S., and Wood, W. B. Microbiology, Harper and Row, New York (1970).