Development and preliminary application of a simple assay of S-mephenytoin 4-hydroxylase activity in human liver microsomes

European Journal of Clinical Pharmacology

Volumn 44, Issue 6, 1993, Pages 559-562

  Chiba, K ^a   Manabe, K ^a,b   Kobayashi, K ^a,b   Takayama, Y ^a,b   Tani, M ^a   Ishizaki, T ^a  

^a NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

HPLC assay; Human liver microsomes; oxidation polymorphism; pharmacogenetics; S mephenytoin 4 hydroxylase

Indexed keywords

MEPHENYTOIN; OXYGENASE;

ARTICLE; DRUG HYDROXYLATION; ENZYME KINETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LIVER MICROSOME; PRIORITY JOURNAL;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPARATIVE STUDY; CYTOCHROME P-450 ENZYME SYSTEM; HUMAN; MEPHENYTOIN; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; OXIDATION-REDUCTION; POLYMORPHISM (GENETICS); SUPPORT, NON-U.S. GOV'T;

EID: 0027316226     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/BF02440859     Document Type: Article

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