A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice

Genes and Development

Volumn 7, Issue 4, 1993, Pages 671-682

  Davis, Ann C ^a   Wims, Marie ^a   Spotts, Gerald D ^b   Hann, Stephen R ^b   Bradley, Allan ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

c myc; Embryonic lethal; Gene targeting; Null mutation

Indexed keywords

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CELL PROLIFERATION; CHIMERA; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; EMBRYO DEVELOPMENT; EMBRYO RESORPTION; FEMALE; GENE FUNCTION; GENE MUTATION; GESTATIONAL AGE; HEART; HETEROZYGOTE; HOMOZYGOTE; LETHAL MUTANT; MOUSE; NEURAL TUBE; NEURAL TUBE DEFECT; NIDATION; NONHUMAN; ONCOGENE C MYC; PERICARDIUM; PRIORITY JOURNAL; SUBFERTILITY; SURVIVAL;

ALLELES; ANIMAL; BASE SEQUENCE; BLOTTING, SOUTHERN; CELL DIFFERENTIATION; CHROMOSOME ABERRATIONS; CHROMOSOME DISORDERS; DNA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EMBRYO; EMBRYO AND FETAL DEVELOPMENT; FEMALE; FETAL DEATH; GENES, LETHAL; GENES, MYC; HETEROZYGOTE; HOMOZYGOTE; INFERTILITY; LITTER SIZE; MALE; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; MUTAGENESIS, SITE-DIRECTED; MUTATION; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-MYC; RECOMBINATION, GENETIC; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027315650     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.7.4.671     Document Type: Article

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