Cortical-striatal-thalamic circuits and brain glucose metabolic activity in 70 unmedicated male schizophrenic patients

American Journal of Psychiatry

Volumn 150, Issue 9, 1993, Pages 1325-1336

  Siegel Jr , Benjamin V ^a   Buchsbaum, Monte S ^b   Bunney Jr , William E ^b   Gottschalk, Louis A ^b   Haier, Richard J ^b   Lohr, James B ^b   Lottenberg, Stephen ^b   Najafi, Ahmad ^b   Nuechterlein, Keith H ^b   Potkin, Steven G ^b   Wu, Joseph C ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GLUCOSE;

ADOLESCENT; ADULT; BRAIN METABOLISM; CAUDATE NUCLEUS; CINGULATE GYRUS; CONFERENCE PAPER; CONTROLLED STUDY; CORPUS CALLOSUM; FRONTAL CORTEX; GLUCOSE BRAIN LEVEL; GLUCOSE METABOLISM; HUMAN; MAJOR CLINICAL STUDY; MALE; OCCIPITAL CORTEX; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SCHIZOPHRENIA; STRIATE CORTEX; TEMPORAL CORTEX; TEMPORAL LOBE; THALAMOCORTICAL TRACT;

ADOLESCENT; ADULT; BASAL GANGLIA; BRAIN; CORPUS STRIATUM; DEOXYGLUCOSE; FLUDEOXYGLUCOSE F 18; FRONTAL LOBE; GLUCOSE; HUMAN; LATERALITY; MALE; MIDDLE AGE; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; THALAMUS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0027305582     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.150.9.1325     Document Type: Article

References (61)

1. Buchsbaum MS: The frontal lobes, basal ganglia, and temporal lobes as sites for schizophrenia. Schizophr Bull 1990; 16:379-389
2. Bunney WE Jr: Schizophrenia - new hypotheses and treatments, in Psychiatry: A World Perspective, vol 2. Edited by Stefanis CN, Soldatos CR, Rabavilas AO. Amsterdam, Elsevier, 1990
3. Carlsson M, Carlsson A: Interactions between glutamatergic and monoaminergic systems within the basal ganglia - implications for schizophrenia and Parkinson's disease. Trends Neurosci 1990; 13:272-276
4. Swerdlow NR, Koob GF: Dopamine, schizophrenia, mania, and depression: toward a unified hypothesis of cortico-striato-pallido-thalamic function. Behav Brain Sci 1987; 10:197-245
5. Buchsbaum MS, Nuechterlein KH, Haier RJ, Wu J, Sicotte N, Hazlett E, Asarnow R, Potkin S, Guich S: Glucose metabolic rate in normals and schizophrenics during the Continuous Performance Test assessed by positron emission tomography. Br J Psychiatry 1990; 156:216-227
6. DeLisi LE, Buchsbaum MS, Holcomb HH, Langston KC, King AC, Kessler R, Pickar D, Carpenter WT, Morihisa JM, Margolin R, Weinberger DR: Increased temporal lobe glucose use in chronic schizophrenic patients. Biol Psychiatry 1989; 25:835-851
7. 15OPositron emission tomographic scanning in predominantly never-treated acute schizophrenic patients. Lancet 1983; 2:1448-1452
8. Wiesel FA, Wik G, Sjogren I, Blomqvist G, Greitz T, Stone-Elander S: Regional brain glucose metabolism in drug free schizophrenic patients and clinical correlates. Acta Psychiatr Scand 1987; 76:628-641
9. Buchsbaum MS, Haier RJ, Potkin SG, Nuechterlein K, Bracha HS, Katz M, Lohr J, Wu J, Lottenberg S, Jerabek PA, Trenary M, Tafalla R, Reynolds C, Bunney WE: Frontostriatal disorder of cerebral metabolism in never-medicated schizophrenics. Arch Gen Psychiatry 1992; 49:935-942
10. DeLisi LE, Holcomb HH, Cohen RM, Pickar D, Carpenter W, Morihisa JM, King AC, Kessler R, Buchsbaum MS: Positron emission tomography in schizophrenic patients with and without neuroleptic medication. J Cereb Blood Flow Metab 1985; 5: 201-206
11. Early TS, Reiman EM, Raichle ME, Spitznagel EL: Left globus pallidus abnormality in never-medicated patients with schizophrenia. Proc Natl Acad Sci USA 1987; 84:561-563
12. Resnick SM, Gur RE, Alavi A, Gur RC, Reivich M: Positron emission tomography and subcortical glucose metabolism in schizophrenia. Psychiatry Res 1988; 24:1-11
13. Wolkin A, Jaeger J, Brodie JD, Wolf AP, Fowler J, Rotrosen J, Gomez-Mont F, Cancro R: Persistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by positron emission tomography. Am J Psychiatry 1985; 142:564-571
14. Buchsbaum MS, Potkin SG, Siegel BV Jr, Lohr J, Katz M, Gottschalk LA, Gulasekaram B, Marshall JF, Lottenberg S, Teng CY, Bunney WE, Abel L, Plon L: Striatal metabolic rate and clinical response to neuroleptics in schizophrenia. Arch Gen Psychiatry 1992; 49:966-974
15. Gur RE, Resnick SM, Alavi A, Gur R, Caroff S, Dann R, Silver FL, Saykin AJ, Chawluk JB, Kushner M, Reivich M: Regional brain function in schizophrenia, I: a positron emission tomography study. Arch Gen Psychiatry 1987; 44:119-125
16. Buchanan RW, Kirkpatrick B, Tamminga CA: Differential patterns of glucose metabolism in deficit and non-deficit schizophrenia. Biol Psychiatry 1989; 25(Suppl 7A):99A-100A
17. Volkow ND, Wolf AP, Van Gelder P, Brodie JD, Overall JE, Cancro R, Gomez-Mont F: Phenomenological correlates of metabolic activity in 18 patients with chronic schizophrenia. Am J Psychiatry 1987; 144:151-158
18. Wik G, Wiesel FA, Sjogren I, Blomqvist G, Greitz T, Stone-Elander S: Effects of sulpiride and chlorpromazine on regional cerebral glucose metabolism in schizophrenic patients as determined by positron emission tomography. Psychopharmacology (Berl) 1989; 97:309-318
19. Buchsbaum MS, Wu JC, DeLisi LE, Holcomb HH, Hazlett E, Cooper-Langston K, Kessler R: Positron emission tomography studies of basal ganglia and somatosensory cortex neuroleptic drug effects: differences between normal controls and schizophrenic patients. Biol Psychiatry 1987; 22:479-494
20. Baxter LR Jr, Mazziotta JC, Phelps ME, Selin CE, Guze BH, Fairbanks L: Cerebral glucose metabolic rates in normal human females versus normal males. Psychiatry Res 1987; 21:237-245
21. Buchsbaum MS, Ingvar DH, Kessler R, Waters RN, Cappelletti J, van Kammen DP, King AC, Johnson JL, Manning RF, Flynn RW, Mann LS, Bunney WE Jr, Sokoloff L: Cerebral glucography with positron tomography. Arch Gen Psychiatry 1982; 39:251-259
22. Buchsbaum MS, DeLisi LE, Holcomb HH, Cappelletti J, King AC, Johnson J, Hazlett E, Dowling-Zimmerman S, Post RM, Morihisa J, Carpenter W, Cohen R, Pickar D, Weinberger DR, Margolin R, Kessler RM: Anteroposterior gradients in cerebral glucose use in schizophrenia and affective disorders. Arch Gen Psychiatry 1984; 41:1159-1166
23. Flor-Henry P: Lateralized temporal-limbic dysfunction and psychopathology. Ann NY Acad Sci 1976; 280:777-797
24. Barta PE, Pearlson GD, Powers RE, Richards SS, Tune LE: Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia. Am J Psychiatry 1990; 147:1457-1462
25. McCarley RW, Faux SF, Shenton M, LeMay M, Cane M, Ballinger R, Duffy FH: CT abnormalities in schizophrenia: a preliminary study of their correlates with P300/P200 electrophysiological features and positive/negative symptoms. Arch Gen Psychiatry 1989; 46:698-708
26. Stuss DT, Benson DF: The Frontal Lobes. New York, Raven Press, 1986
27. Williamson P, Pelz D, Merskey H, Morrison S, Conlon P: Correlation of negative symptoms in schizophrenia with frontal lobe parameters on magnetic resonance imaging. Br J Psychiatry 1991; 159:130-134
28. Uematsu M, Kaiya H: Midsaggital cortical pathomorphology of schizophrenia: a magnetic resonance imaging study. Psychiatry Res 1989; 30:11-20
29. Wing JK, Cooper JE, Sartorius N: The Measurement and Classification of Psychiatric Symptoms: An Instructional Manual for the PSE and CATEGO Programs. New York, Cambridge University Press, 1974
30. Overall JE, Gorham DR: The Brief Psychiatric Rating Scale. Psychol Rep 1962; 10:799-812
31. Nuechterlein KH, Parasuraman R, Jiang Q: Visual sustained attention: image degradation produces rapid decrement over time. Science 1983; 220:327-329
32. Buchsbaum MS, Gillin JC, Wu J, Hazlett E, Sicotte N, DuPont RM: Regional cerebral glucose metabolic rate in human sleep assessed by positron emission tomography. Life Sci 1989; 45: 1349-1356
33. Matsui T, Hirano A: An Atlas of the Human Brain for Computerized Tomography. Tokyo, Igaku-Shoin, 1978
34. Buchsbaum MS, Potkin SG, Marshall JF, Lottenberg S, Teng C, Heh CW, Tafalla R, Reynolds C, Abel L, Plon L, Bunney WE Jr: Effects of clozapine and thiothixene on glucose metabolic rate in schizophrenia. Neuropsychopharmacology 1992; 6:155-163
35. Dixon WJ: BMDP Statistical Software. Berkeley, University of California Press, 1981, pp 388-412
36. Thiemann S, Csernansky JG, Berger PA: Rating scales in research: the case of negative symptoms. Psychiatry Res 1987; 20: 47-55
37. Opler LA, Kay SR, Rosado V, Lindenmayer J-P: Positive and negative syndromes in chronic schizophrenic inpatients. J Nerv Ment Dis 1984; 172:317-325
38. Ingvar DH, Franzen G: Abnormalities in cerebral blood flow distribution in patients with chronic schizophrenia. Acta Psychiatr Scand 1974; 50:425-462
39. Weinberger DR, Berman KF, Zee RF: Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia, I: regional cerebral blood flow evidence. Arch Gen Psychiatry 1986; 43:114-124
40. Adler LE, Pachtman E, Franks RD, Pecevich M, Waldo MC, Freedman R: Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia. Biol Psychiatry 1982; 17:639-654
41. Braff DL, Grillon C, Geyer MA: Gating and habituation of the startle reflex in schizophrenic patients. Arch Gen Psychiatry 1992; 49:206-215
42. Geyer MA, Swerdlow NR, Mansbach RS, Braff DL: Startle response models of sensorimotor gating and habituation deficits in schizophrenia. Behav Res Bull 1990; 25:1-14
43. Pakkenberg B: Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics. Arch Gen Psychiatry 1990; 47:1023-1028
44. Andreasen NC, Ehrhardt JC, Swayze VW, Alliger RJ, Yuh WTC, Cohen G, Ziebell S: Magnetic resonance imaging of the brain in schizophrenia: the pathophysiologic significance of structural abnormalities. Arch Gen Psychiatry 1990; 47:35-44
45. Kelsoe JR Jr, Cadet JL, Pickar D, Weinberger DR: Quantitative neuroanatomy in schizophrenia: a controlled magnetic resonance imaging study. Arch Gen Psychiatry 1988; 45:533-541
46. Szechtman HJ, Nahmias C, Garnett ES, Firnau G, Brown GM, Kaplan RD, Cleghorn JM: Effect of neuroleptics on altered cerebral glucose metabolism in schizophrenia. Arch Gen Psychiatry 1988; 45:523-532
47. Volkow VD, Wolf AP, Brodie JD, Cancro R, Overall JE, Rhoades H, Van Gelder P: Brain interactions in chronic schizophrenics under resting and activation conditions. Schizophr Res 1988; 1:47-53
48. Piercey MF, Ray CA: Dramatic limbic and cortical effects mediated by high affinity PCP receptors. Life Sci 1988; 43:379-385
49. Gur RE, Gur RC, Skolnick BE, Caroff S, Obrist WD, Resnick S, Reivich M: Brain function in psychiatric disorders, III: regional cerebral blood flow in unmedicated schizophrenics. Arch Gen Psychiatry 1985; 42:329-334
50. Crow TJ, Ball J, Bloom SR, Brown R, Bruton CJ, Colter N, Frith CD, Johnstone EC, Owens DGC, Roberts GW: Schizophrenia as an anomaly of development of cerebral asymmetry: a postmortem study and a proposal concerning the genetic basis of the disease. Arch Gen Psychiatry 1989; 46:1145-1150
51. Falkai P, Bogerts B, Rozumek M: Limbic pathology in schizophrenia: the entorhinal region - a morphometric study. Biol Psychiatry 1988; 24:515-521
52. Jakob H, Beckmann H: Prenatal developmental disturbances in the limbic allocortex of schizophrenics. J Neural Transm 1986; 65:303-326
53. Gruzelier JH, Manchanda R: The syndrome of schizophrenia: relation between electrodermal responses, lateral asymmetries and clinical ratings. Br J Psychiatry 1982; 141:488-495
54. Tomarken AJ, Davidson RJ, Henriques JB: Resting frontal brain asymmetry predicts affective responses to films. J Pers Soc Psychol 1990; 59:791-801
55. Tucker DM, Stenslie CE, Roth RS, Shearer SL: Right frontal lobe activation and right hemisphere performance decrement during a depressed mood. Arch Gen Psychiatry 1981; 38:169-174
56. Bigelow LB, Nasrallah HA, Rauscher FP: Corpus callosum thickness in chronic schizophrenia. Br J Psychiatry 1983; 142:284-287
57. Nasrallah HA, McCalley-Whitters M, Bigelow LB, Rauscher FP: A histological study of the corpus callosum in chronic schizophrenia. Psychiatry Res 1983; 8:251-260
58. Raine A, Harrison GN, Reynolds GP, Sheard C, Cooper JE, Medley I: Structural and functional characteristics of the corpus callosum in schizophrenics, psychiatric controls, and normal controls: a magnetic resonance imaging and neuropsychological evaluation. Arch Gen Psychiatry 1990; 47:1060-1064
59. Gulmann NC, Wildschiodtz G, Orbaek K: Alteration of interhemisphere conduction through corpus callosum in schizophrenia. Biol Psychiatry 1982; 17:585-594
60. Jones GH, Miller JJ: Functional tests of the corpus callosum in schizophrenia. Br J Psychiatry 1981; 139:553-557
61. Nasrallah HA: The unintegrated right cerebral hemispheric consciousness as alien intruder: a possible mechanism for Schneiderian delusions in schizophrenia. Compr Psychiatry 1985; 26-273-282