메뉴 건너뛰기




Volumn 5, Issue 6, 1993, Pages 647-656

Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus

Author keywords

B cell deficient mice; B cell development; Ig gene rearrangement; JH locus; Targeted mutation

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; LEUKOSIALIN;

EID: 0027305425     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/5.6.647     Document Type: Article
Times cited : (354)

References (57)
  • 1
    • 0023513107 scopus 로고
    • Development of the primary antibody repertoire
    • Alt, F. W., Blackwell, T. K., and Yancopoulos, G. D. 1987 Development of the primary antibody repertoire. Science 238:1079.
    • (1987) Science , vol.238 , pp. 1079
    • Alt, F.W.1    Blackwell, T.K.2    Yancopoulos, G.D.3
  • 2
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • Tonegawa, S. 1983. Somatic generation of antibody diversity Nature 302:575.
    • (1983) Nature , vol.302 , pp. 575
    • Tonegawa, S.1
  • 4
    • 0021047154 scopus 로고
    • Immunoglobulin gene rearrangement during pre-B cell differentiation
    • Coffman, R L. and Weissman, I. L. 1983. Immunoglobulin gene rearrangement during pre-B cell differentiation. J. Md. Cell. Immund. 1:31.
    • (1983) J. Md. Cell. Immund , vol.1 , pp. 31
    • Coffman, R.L.1    Weissman, I.L.2
  • 5
    • 0025868702 scopus 로고
    • Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
    • Flardy, R. R., Carmack, C. E, Shinton, S. A., Kemp, J. D, and Flayakawa, K. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173:1213.
    • (1991) J. Exp. Med , vol.173 , pp. 1213
    • Flardy, R.R.1    Carmack, C.E.2    Shinton, S.A.3    Kemp, J.D.4    Flayakawa, K.5
  • 6
    • 0018929067 scopus 로고
    • Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain
    • Alt, F. W., Enea, V., Bothwell, A. L., and Baltimore, D 1980. Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain. Cell 21.1.
    • (1980) Cell , vol.21 , pp. 1
    • Alt, F.W.1    Enea, V.2    Bothwell, A.L.3    Baltimore, D.4
  • 7
    • 0025766890 scopus 로고
    • Molecular and cellular origins of B lymphocyte diversity
    • Rolink, A and Melchers, F. 1991. Molecular and cellular origins of B lymphocyte diversity. Cell 68:1081.
    • (1991) Cell , vol.68 , pp. 1081
    • Rolink, A.1    Melchers, F.2
  • 8
    • 0019455850 scopus 로고
    • Fluman immunoglobulin * light-chain genes are deleted or rearranged in X-producing B cells
    • Hieter, P. A., Korsmeyer, S. J, Waldmann, T. A., and Leder, P. 1981. Fluman immunoglobulin * light-chain genes are deleted or rearranged in X-producing B cells. Nature 290:368.
    • (1981) Nature , vol.290 , pp. 368
    • Hieter, P.A.1    Korsmeyer, S.J.2    Waldmann, T.A.3    Leder, P.4
  • 9
    • 0019494043 scopus 로고
    • Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression
    • Coledough, C., Perry, R P., Karjalainen, K., and Weigert, M. 1981 Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression. Nature 290:372.
    • (1981) Nature , vol.290 , pp. 372
    • Coledough, C.1    Perry, R.P.2    Karjalainen, K.3    Weigert, M.4
  • 11
    • 0027447365 scopus 로고
    • Gene targeting in the Igx locus: Efficient generation of X chain expressing B cells independent of gene rearrangements in Igx
    • Zou, Y.-R., Takeda, S., and Ftajewsky, K. 1993. Gene targeting in the Igx locus: efficient generation of X chain expressing B cells independent of gene rearrangements in Igx. EMBO J. 12:811.
    • (1993) EMBO J , vol.12 , pp. 811
    • Zou, Y.-R.1    Takeda, S.2    Ftajewsky, K.3
  • 13
    • 0026750092 scopus 로고
    • Antigen receptors on B lymphocytes. Annu
    • Reth, M. 1992. Antigen receptors on B lymphocytes. Annu. Rev. Immund. 10:97.
    • (1992) Rev. Immund , vol.10 , pp. 97
    • Reth, M.1
  • 14
    • 0025968657 scopus 로고
    • The «/X5 surrogate immunoglobulin light chain is expressed on the surface of transitional B lymphocytes in murine bone marrow
    • Cherayil, B. J. and Pillai, S. 1991. The «/X5 surrogate immunoglobulin light chain is expressed on the surface of transitional B lymphocytes in murine bone marrow. J. Exp. Med. 173:111.
    • (1991) J. Exp. Med , vol.173 , pp. 111
    • Cherayil, B.J.1    Pillai, S.2
  • 15
    • 0021933994 scopus 로고
    • Regulated progression of a cultured pre-B-cell line to the B-cell stage
    • Reth, M. G., Ammiirati, P., Jackson, S., and Alt, F. W. 1985. Regulated progression of a cultured pre-B-cell line to the B-cell stage. Nature 317, 353.
    • (1985) Nature , vol.317 , pp. 353
    • Reth, M.G.1    Ammiirati, P.2    Jackson, S.3    Alt, F.W.4
  • 17
    • 0025895046 scopus 로고
    • Molecular requirements for the ji-induced light chain gene rearrangement in pre-B cells
    • Iglesias, A., Kopf, M., Williams, G. S., Buhler, B, and Kohler, G. 1991. Molecular requirements for the ji-induced light chain gene rearrangement in pre-B cells. EMBO J. 10.2147.
    • (1991) EMBO J , vol.10 , pp. 2147
    • Iglesias, A.1    Kopf, M.2    Williams, G.S.3    Buhler, B.4    Kohler, G.5
  • 18
    • 0026096955 scopus 로고
    • Signal transmission through the Bcell specific MB-1 molecule at the pre-B cell stage
    • Nomura, J., Matsuo, T., Kubota, E., Kimoto, M., and Sakaguchi, N. 1991. Signal transmission through the Bcell specific MB-1 molecule at the pre-B cell stage. Int. Immund. 3117.
    • (1991) Int. Immund , pp. 3117
    • Nomura, J.1    Matsuo, T.2    Kubota, E.3    Kimoto, M.4    Sakaguchi, N.5
  • 19
    • 0026583842 scopus 로고
    • Targeted disruption of p chain membrane exon causes loss of heavy-chain allelic exclusion
    • KHamura, D. and Rajewsky, K. 1992. Targeted disruption of p chain membrane exon causes loss of heavy-chain allelic exclusion. Nature 356:154.
    • (1992) Nature , vol.356 , pp. 154
    • Khamura, D.1    Rajewsky, K.2
  • 21
    • 0024435908 scopus 로고
    • Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription
    • Schlissel, M S. and Baltimore, D. 1989. Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription. Cdl 58.1001.
    • (1989) Cdl , vol.58 , pp. 1001
    • Schlissel, M.S.1    Baltimore, D.2
  • 22
    • 0024553137 scopus 로고
    • Light-chain gene expression before heavy-chain gene rearrangement in pre-B cells transformed by Epstein Barr virus
    • Kubagawa, FI., Cooper, M., Carroll, A. J., and Burrows, P. D. 1989. Light-chain gene expression before heavy-chain gene rearrangement in pre-B cells transformed by Epstein Barr virus. Proc. Natl Acad. Sd. USA 86:2350.
    • (1989) Proc. Natl Acad. Sd. USA , vol.86 , pp. 2350
    • Kubagawa, F.I.1    Cooper, M.2    Carroll, A.J.3    Burrows, P.D.4
  • 23
    • 0021891053 scopus 로고
    • The in vitro development of blastocyst-derived embryonic stem cell lines: Formation of visceral yolk sac, blood islands and myocardium
    • Doetschman, T. C, Eistetter, FI., Katz, M., Schmidt, W., and Kemler, R. 1985. The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium. J Embryo!. Exp Morphoi 87:27.
    • (1985) J Embryo!. Exp Morphoi , vol.87 , pp. 27
    • Doetschman, T.C.1    Eistetter, F.I.2    Katz, M.3    Schmidt, W.4    Kemler, R.5
  • 25
    • 0025780879 scopus 로고
    • Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
    • Tybulewicz, V. L. J., Crawford, C. E, Jackson, P. J., Bronson, R. T., and Mulligan, R. C. 1991. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65:1153.
    • (1991) Cell , vol.65 , pp. 1153
    • Tybulewicz, V.L.J.1    Crawford, C.E.2    Jackson, P.J.3    Bronson, R.T.4    Mulligan, R.C.5
  • 26
    • 0025188130 scopus 로고
    • The Wnt-1 (/nf-1) protooncogene is required for development of a large region of the mouse brain
    • McMahon, A. P. and Bradley, A. 1990. The Wnt-1 (/nf-1) protooncogene is required for development of a large region of the mouse brain. Cell 62:1073.
    • (1990) Cell , vol.62 , pp. 1073
    • McMahon, A.P.1    Bradley, A.2
  • 28
    • 0025907129 scopus 로고
    • Migration and proliferation of cultured neural crest cells in W mutant neural crest chimeras
    • Huszar, D., Sharpe, A., and Jaenisch, R. 1991. Migration and proliferation of cultured neural crest cells in W mutant neural crest chimeras. Development 112:131.
    • (1991) Development , vol.112 , pp. 131
    • Huszar, D.1    Sharpe, A.2    Jaenisch, R.3
  • 30
    • 0003301134 scopus 로고
    • Weir, D M, Herzenberg, L. A., Blackwell, C. C., and Herzenberg, L. A., eds, Blackwell Scientific, London
    • Parks, D. R., Lanier, L. L, and Herzenberg, L. A 1986. In Weir, D M, Herzenberg, L. A., Blackwell, C. C., and Herzenberg, L. A., eds., Handbook of Experimental Immunology, p. 29.1. Blackwell Scientific, London
    • (1986) Handbook of Experimental Immunology , vol.1 , pp. 29
    • Parks, D.R.1    Lanier, L.L.2    Herzenberg, L.A.3
  • 31
    • 0017111732 scopus 로고
    • A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus
    • Rosenberg, N. and Baltimore, D. 1976. A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus. J. Exp. Med. 143.1453.
    • (1976) J. Exp. Med , vol.143 , pp. 1453
    • Rosenberg, N.1    Baltimore, D.2
  • 32
    • 0023646810 scopus 로고
    • Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
    • Thomas, K. R. and Capecchi, M R. 1987. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51:503.
    • (1987) Cell , vol.51 , pp. 503
    • Thomas, K.R.1    Capecchi, M.R.2
  • 33
    • 0024296027 scopus 로고
    • Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes
    • Mansour, S. L., Thomas, K. R., and Capecchi, M. R. 1988. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes. Nature 336:348.
    • (1988) Nature , vol.336 , pp. 348
    • Mansour, S.L.1    Thomas, K.R.2    Capecchi, M.R.3
  • 36
    • 0019846013 scopus 로고
    • Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: Rearrangement of heavy but not Bght chain genes
    • Alt, F. W., Rosenberg, N., Lewis, S., Thomas, E., and Baltimore, D. 1981 Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: rearrangement of heavy but not Bght chain genes. Cdl 27:381.
    • (1981) Cdl , vol.27 , pp. 381
    • Alt, F.W.1    Rosenberg, N.2    Lewis, S.3    Thomas, E.4    Baltimore, D.5
  • 37
    • 0020464847 scopus 로고
    • Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus
    • Lewis, S., Rosenberg, N., Aft, F. W., and Baltimore, D. 1982. Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus. Cdl 30:807.
    • (1982) Cdl , vol.30 , pp. 807
    • Lewis, S.1    Rosenberg, N.2    Aft, F.W.3    Baltimore, D.4
  • 40
    • 0023228897 scopus 로고
    • Active lambda and kappa antibody gene rearrangement in Abelson murine leukemia virus-transformed pre-B cell lines
    • Persiani, D. M., Durdik, J., and Seising, E. 1987. Active lambda and kappa antibody gene rearrangement in Abelson murine leukemia virus-transformed pre-B cell lines. J. Exp. Med. 165:1655.
    • (1987) J. Exp. Med , vol.165 , pp. 1655
    • Persiani, D.M.1    Durdik, J.2    Seising, E.3
  • 41
    • 84968453069 scopus 로고
    • Immunoglobubn genes
    • Hames, B D. and Glover, D. M., eds., IRL Press, Oxford
    • Blackwell, T. K. and Alt, F. W. 1988. Immunoglobubn genes. In Hames, B D. and Glover, D. M., eds., Frontiers in Molecular Biology. IRL Press, Oxford.
    • (1988) Frontiers in Molecular Biology
    • Blackwell, T.K.1    Alt, F.W.2
  • 42
    • 0021983551 scopus 로고
    • Developmental controlled and tissue-specific expression of unrearranged VH gene segments
    • Yancopoulos, G. D and Alt, F. W. 1985. Developmental controlled and tissue-specific expression of unrearranged VH gene segments. Cell 40:271.
    • (1985) Cell , vol.40 , pp. 271
    • Yancopoulos, G.D.1    Alt, F.W.2
  • 43
    • 0025924685 scopus 로고
    • Coordination of immunoglobulin DJH transcription and D-to-JH rearrangement by promoter-enhancer approximation. Mol. Cell
    • Alessandrini, A. and Desiderio, S. V. 1991. Coordination of immunoglobulin DJH transcription and D-to-JH rearrangement by promoter-enhancer approximation. Mol. Cell. Biol. 11:2096.
    • (1991) Biol , vol.11 , pp. 2096
    • Alessandrini, A.1    Desiderio, S.V.2
  • 46
    • 0025772885 scopus 로고
    • Independent rearrangement of Igl genes in tissue culture-derived murine B cell lines
    • Felsher, D. W., Ando, D. T, and Braun, J. 1991. Independent rearrangement of Igl genes in tissue culture-derived murine B cell lines. Int. Immunol. 3:711.
    • (1991) Int. Immunol , vol.3 , pp. 711
    • Felsher, D.W.1    O, D.T.2    Braun, J.3
  • 47
  • 49
    • 0019163250 scopus 로고
    • Immunoglobulin gene rearrangement in immature B cells
    • Maki, R., Kearney, J. F, Paige, C., and Tonegawa, S. 1980. Immunoglobulin gene rearrangement in immature B cells. Science 209:1366.
    • (1980) Science , vol.209 , pp. 1366
    • Maki, R.1    Kearney, J.F.2    Paige, C.3    Tonegawa, S.4
  • 50
  • 53
    • 0023261758 scopus 로고
    • Epstein -Barr virus-transformed human precursor B cell lines: Altered growth phenotype of lines with germ-line or rearranged but nonexpressed heavy chain gene
    • Gregory, C. D., Kirchgen, C., Edwards, C. F., Young, L. S., Rowe, M., Forster, M., Rabbits, T. H., and Rickinson, A. B. 1987. Epstein -Barr virus-transformed human precursor B cell lines: Altered growth phenotype of lines with germ-line or rearranged but nonexpressed heavy chain gene. Eur. J. Immunol. 17:1199.
    • (1987) Eur. J. Immunol , vol.17 , pp. 1199
    • Gregory, C.D.1    Kirchgen, C.2    Edwards, C.F.3    Young, L.S.4    Rowe, M.5    Forster, M.6    Rabbits, T.H.7    Rickinson, A.B.8
  • 54
    • 0025852445 scopus 로고
    • A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin p chain gene
    • Kitamura, D., Roes, J, Kuhn, R., and Rajewsky, K. 1991. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin p chain gene. Nature 350:423.
    • (1991) Nature , vol.350 , pp. 423
    • Kitamura, D.1    Roes, J.2    Kuhn, R.3    Rajewsky, K.4
  • 55
    • 0026019627 scopus 로고
    • Differentiation of growth signal requirement of B lymphocyte precursor is directed by expression of immunoglobulin
    • Era, T., Ogawa, M., Nishikawa, S.-l., Okamoto, M., Honjo, T, Akagi, K., Miyazaki, J.-l., and Yamamura, K.-l. 1991. Differentiation of growth signal requirement of B lymphocyte precursor is directed by expression of immunoglobulin. EMBO J. 10:337.
    • (1991) EMBO J , vol.10 , pp. 337
    • Era, T.1    Ogawa, M.2    Nishikawa, S.-L.3    Okamoto, M.4    Honjo, T.5    Akagi, K.6    Miyazaki, J.-L.7    Yamamura, K.-L.8
  • 56
    • 0027406812 scopus 로고
    • Restoration of T cell development in RAG-2 deficient mice by functionally rearranged TCR transgenes
    • Shinkai, Y., Koyasu, S., Nakayama, K., Murphy, K. M., Loh, D. Y., Reinherz, E. L, and Art, F W. 1993. Restoration of T cell development in RAG-2 deficient mice by functionally rearranged TCR transgenes. Science 259, 984.
    • (1993) Science , vol.259 , pp. 984
    • Shinkai, Y.1    Koyasu, S.2    Nakayama, K.3    Murphy, K.M.4    Loh, D.Y.5    Reinherz, E.L.6    Art, F.W.7
  • 57
    • 0026553004 scopus 로고
    • Early and late B-cell development in the mouse
    • Rajewsky, K. 1992. Early and late B-cell development in the mouse Curr. Opin Immunol. 4.171.
    • (1992) Curr. Opin Immunol , vol.4 , pp. 171
    • Rajewsky, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.