메뉴 건너뛰기




Volumn 36, Issue 17, 1993, Pages 2578-2579

Nitrobenzyl Mustard Quaternary Salts: A New Class of Hypoxia-Selective Cytotoxins Showing Very High in Vitro Selectivity

Author keywords

[No Author keywords available]

Indexed keywords

CHLORMETHINE; CYTOTOXIN; N,N BIS(2 CHLOROETHYL) 2 NITROBENZYLAMINE DERIVATIVE; QUATERNARY AMMONIUM DERIVATIVE; UNCLASSIFIED DRUG;

EID: 0027304445     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00069a019     Document Type: Editorial
Times cited : (34)

References (20)
  • 1
    • 0010313514 scopus 로고
    • Tumour hypoxia: challenges for cancer chemotherapy
    • Waring, M. J., Ponder, B. A. J., Eds.; Kluwer: Lancaster
    • Wilson, W. R. Tumour hypoxia: challenges for cancer chemotherapy. In, Cancer Biology and Medicine. Vol. 3. The Search for Anticancer Drugs; Waring, M. J., Ponder, B. A. J., Eds.; Kluwer: Lancaster, 1992; pp 87–132.
    • (1992) Cancer Biology and Medicine. The Search for Anticancer Drugs , vol.3 , pp. 87-132
    • Wilson, W.R.1
  • 2
    • 0026698228 scopus 로고
    • Use of hypoxia-selective drugs in therapy of solid tumors
    • Rockwell, S. Use of hypoxia-selective drugs in therapy of solid tumors. Semin. Oncol. 1992, 19, 29–40.
    • (1992) Semin. Oncol. , vol.19 , pp. 29-40
    • Rockwell, S.1
  • 4
    • 0001524664 scopus 로고
    • Electron transfer processes. VIII. Coupling reactions of radicals with carbanions
    • Russell, G. A.; Danen, W. C. Electron transfer processes. VIII. Coupling reactions of radicals with carbanions. J. Am. Chem. Soc. 1968, 90, 347–353.
    • (1968) J. Am. Chem. Soc. , vol.90 , pp. 347-353
    • Russell, G.A.1    Danen, W.C.2
  • 5
    • 13344271794 scopus 로고
    • The electron paramagnetic resonance of spectra of α-substituted nitrotoluene anion radicals. The influence of electron-withdrawing substituents on the coupling constants for β-hydrogen atoms
    • Stock, L. M.; Wasielewski, M. R. The electron paramagnetic resonance of spectra of α-substituted nitrotoluene anion radicals. The influence of electron-withdrawing substituents on the coupling constants for β-hydrogen atoms. J. Am. Chem. Soc. 1975, 97, 5620–5622.
    • (1975) J. Am. Chem. Soc. , vol.97 , pp. 5620-5622
    • Stock, L.M.1    Wasielewski, M.R.2
  • 6
    • 0023038416 scopus 로고
    • Nitrobenzyl radical metabolites from microsomal reduction of nitrobenzyl chlorides
    • Moreno, S. N. J.; Schreiber, J.; Mason, R. P. Nitrobenzyl radical metabolites from microsomal reduction of nitrobenzyl chlorides. J. Biol. Chem. 1986, 261, 7811–7815.
    • (1986) J. Biol. Chem. , vol.261 , pp. 7811-7815
    • Moreno, S.N.J.1    Schreiber, J.2    Mason, R.P.3
  • 7
    • 0005410044 scopus 로고
    • Substituent effects. 6. Charged groups: a simple extension of the Hammett equation
    • Hoefnagel, A. J.; Hoefnagl, M. A.; Wepster, B. M. Substituent effects. 6. Charged groups: a simple extension of the Hammett equation. J. Org. Chem. 1978, 43, 4720–4745.
    • (1978) J. Org. Chem. , vol.43 , pp. 4720-4745
    • Hoefnagel, A.J.1    Hoefnagl, M.A.2    Wepster, B.M.3
  • 8
    • 0022535929 scopus 로고
    • Considerations for the design of nitrophenyl mustards as agents with selective toxicity for hypoxic tumor cells
    • Denny, W. A.; Wilson, W. R. Considerations for the design of nitrophenyl mustards as agents with selective toxicity for hypoxic tumor cells. J. Med. Chem. 1986, 29, 879–887.
    • (1986) J. Med. Chem. , vol.29 , pp. 879-887
    • Denny, W.A.1    Wilson, W.R.2
  • 9
    • 0018168723 scopus 로고
    • Cell kinetics and chemotherapy; a critical review
    • Tannock, I. Cell kinetics and chemotherapy; a critical review. Cancer Treatment Rep. 1978, 62, 1117–1133.
    • (1978) Cancer Treatment Rep. , vol.62 , pp. 1117-1133
    • Tannock, I.1
  • 11
    • 85022723587 scopus 로고    scopus 로고
    • Bioreducible mustards; a paradigm for hypoxia-selective prodrugs of diffusible cytotoxins (HPDCs)
    • In press
    • Denny, W. A.; Wilson, W. R. Bioreducible mustards; a paradigm for hypoxia-selective prodrugs of diffusible cytotoxins (HPDCs). Cancer Met. Rev. In press.
    • Cancer Met. Rev.
    • Denny, W.A.1    Wilson, W.R.2
  • 12
    • 33847087742 scopus 로고
    • Intramolecular electron transfer in the anion radicals of nitrobenzyl halides
    • Neta, P.; Behar, D. Intramolecular electron transfer in the anion radicals of nitrobenzyl halides. J. Am. Chem. Soc. 1980, 102, 4798–4802.
    • (1980) J. Am. Chem. Soc. , vol.102 , pp. 4798-4802
    • Neta, P.1    Behar, D.2
  • 13
    • 0021098229 scopus 로고
    • Intramolecular electron transfer and dehalogenation of nitroaromatic anion radicals
    • Bays, J. P.; Blumer, S. T.; Baral-Tosh, S.; Behar, D.; Neta, P. Intramolecular electron transfer and dehalogenation of nitroaromatic anion radicals. J. Am. Chem. Soc. 1983, 105, 320–324.
    • (1983) J. Am. Chem. Soc. , vol.105 , pp. 320-324
    • Bays, J.P.1    Blumer, S.T.2    Baral-Tosh, S.3    Behar, D.4    Neta, P.5
  • 14
    • 0001474585 scopus 로고
    • Steric effects on dehalogenation of anion radicals derived from substituted nitrobenzyl halides
    • Norris, R. K.; Barker, S. D.; Neta, P. Steric effects on dehalogenation of anion radicals derived from substituted nitrobenzyl halides. J. Am. Chem. Soc. 1984, 106, 3140–3144.
    • (1984) J. Am. Chem. Soc. , vol.106 , pp. 3140-3144
    • Norris, R.K.1    Barker, S.D.2    Neta, P.3
  • 15
    • 0014415892 scopus 로고
    • Potential carcinolytic Agents. VI. New deactivated biological alkylating agents
    • Papanastassiou, Z. B.; Bruni, R. J.; White, E. V. Potential carcinolytic Agents. VI. New deactivated biological alkylating agents. Experienta 1968, 24, 325.
    • (1968) Experienta , vol.24 , pp. 325
    • Papanastassiou, Z.B.1    Bruni, R.J.2    White, E.V.3
  • 17
    • 0024491246 scopus 로고
    • Hypoxia-selective antitumor agents. 1. Relationship between structure, redox properties and hypoxia-selective cytotoxicity for 4-substituted derivatives of nitracrine
    • Wilson, W. R.; Anderson, R. F.; Denny, W. A. Hypoxia-selective antitumor agents. 1. Relationship between structure, redox properties and hypoxia-selective cytotoxicity for 4-substituted derivatives of nitracrine. J. Med. Chem. 1989, 32, 23–30.
    • (1989) J. Med. Chem. , vol.32 , pp. 23-30
    • Wilson, W.R.1    Anderson, R.F.2    Denny, W.A.3
  • 18
    • 0021824209 scopus 로고
    • Defective DNA crosslink removal in Chinese hamster cell mutants hypersensitive to bifunctional alkylating agents
    • Hoy, C. A.; Thompson, L. H.; Mooney, C. L.; Salazar, E. P. Defective DNA crosslink removal in Chinese hamster cell mutants hypersensitive to bifunctional alkylating agents. Cancer Res. 1985, 1737–1743.
    • (1985) Cancer Res. , pp. 1737-1743
    • Hoy, C.A.1    Thompson, L.H.2    Mooney, C.L.3    Salazar, E.P.4
  • 19
    • 0025043947 scopus 로고
    • Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples
    • Baker, M. A.; Cemiglia, G. J.; Zaman, A. Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples. Anal. Biochem. 1990, 190, 360–365.
    • (1990) Anal. Biochem. , vol.190 , pp. 360-365
    • Baker, M.A.1    Cemiglia, G.J.2    Zaman, A.3
  • 20
    • 0022272179 scopus 로고
    • Some reactions and properties of nitro radical anions important in biology and medicine
    • Wardman, P. Some reactions and properties of nitro radical anions important in biology and medicine. Environ. Health Perspect. 1985, 63, 309–320.
    • (1985) Environ. Health Perspect. , vol.63 , pp. 309-320
    • Wardman, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.