Role of endogenous substance P in stress-induced activation of mesocortical dopamine neutrons
P.J.
Bannon, M.J., P.J. Elliot, J.E. Alpert, M. Goedert, S.D. Iversen and L.L. Iversen, Role of endogenous substance P in stress-induced activation of mesocortical dopamine neutrons, Nature 306, 791.
Glycine reverses antagonism of N-methyl-D-aspartate (NMDA) by 1-hydroxy-3-aminopyrrolidone-2 (HA-966) but not by D-2-amino-5-phosphonovalerate (D-AP5) on rat cortical slices
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(+)-1-Hydroxyγ-3-aminopyrrolidone-2 (HA-966) inhibits activity of substantia nigra dopamine neurons through a non-methyl-D-aspartate receptor- mediated mechanism
Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D- aspartate receptor antagonist, but (−)-HA-966 is a potent gamma-butyrolactone-like sedative