Decreased E-Cadherin Immunoreactivity Correlates with Poor Survival in Patients with Bladder Thmors

Cancer Research

Volumn 53, Issue 14, 1993, Pages 3241-3245

  Paul Bringuier, Pierre ^a   Umbas, Rainy ^a   Ewout Schaafsma, H ^b   Karthaus, Herbert F M ^b   Debruyne, Frans M J ^a   Schalken, Jack A ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b CANISIUS WILHELMINA HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

UVOMORULIN;

ADULT; AGED; ARTICLE; BLADDER TUMOR; CANCER GRADING; CANCER INVASION; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; BLADDER NEOPLASMS; CADHERINS; CARCINOMA, SQUAMOUS CELL; CARCINOMA, TRANSITIONAL CELL; HUMAN; MIDDLE AGE; PROGNOSIS; SUPPORT, NON-U.S. GOV'T; SURVIVAL ANALYSIS; TUMOR CELLS, CULTURED;

EID: 0027301125     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Raghavan, D. Shipley, W. U. Garnick, M. C. Russell, P. J. and Richie J. P. Biology and management of bladder cancer. N. Engl. J. Med. 322: 1129-1138, 1990.
2. Takeichi, M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science (Washington DC), 251: 1451-1455, 1991.
3. Behrens, J. Birchmeier, W. Goodman, S. L. and Imhof, B. A. Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-arc-1: mechanistic aspects and identification of the antigen as a component related to uvomorulin. J. Cell Biol. 101: 1307-1315, 1985.
4. Gumbiner, B. Stevenson, B. and Grimaldi, A. The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex. J. Cell Biol. 107: 1575-1587, 1988.
5. Sommers, C. L. Thompson, E. W. Torri, J. A. Kemler, R. Gelmann, E. P. and Byers, S. W. Cell adhesion molecule uvomorulin expression in human breast cancer cell lines: relationship to morphology and invasive capacity. Cell Growth & Differ. 2: 365-372, 1991.
6. Hyafil, E. Morello, D. Babinet C, and Jacob, F. Cell-cell interactions in early embryogenesis: a molecular approach to the role of calcium. Cell, 26:447-454,1981.
7. Duband, J. L. Dufour, S. Hatta, K. Takeichi, M. Edelman, G. M. and Thiery, J. P. Adhesion molecules during somitogenesis in the avian embryo. J. Cell Biol. 104: 1361-1374, 1987.
8. Larjava, H. Peltonen, J. Akiyama, S. K. Yamada, S. S. Gralnick, H. R. Uitto, J. and Yamada, K. M. Novel function for 0i intcgrins in keratinocyte cell-cell interactions. J. Cell Biol. 770; 803-815, 1990.
9. Behrens, J. Marcel, M. M. Van Roy, F. M. and Birchmeier, W. Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J. CeU Biol. 708; 2435-2447, 1989.
10. Frixen, U. H., Behrens, J. Sachs, M. Eberle, G. Voss, B. Warda, A. Lochner, D. and Birchmeier, W. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J. Cell Biol. 113: 173-185. 1991.
11. Vleminckx, K. Vakaet, J. L. Marcel, M. Fiers. W. and Van Roy, F. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell, 66: 107-119, 1991.
12. Eidelman, S. Damsky, C. H. Wheelock, M. J. and Damjanof, I. Expression of the cell-cell adhesion glycoprotein cell-CAM 120/80 in normal human tissues and tumors. Am. J. Pathol. 135: 101-110, 1989.
13. Umbas, R. Isaacs, W. B. Aalders, T. W. Carter. B. S. Karthaus, H. F. M. Schaafsma, H. E. and Debruyne, F. M. J. Decreased expression of E-cadherin in high grade prostate cancer. Cancer Res. 52: 5104-5108, 1992.
14. Shiozaki, H. Tahara, H. Oka H. Miyata, M. Kobayashi, K. Tamura, S. Lihara. K. Doki, Y. Hirano, S. Takeichi, M. and Mori, T. Expression of immunoreactive E cadherin adhesion molecule in human cancers. Am. J. Pathol. 139: 17-23, 1991.
15. Nowell, P. C. Mechanisms of tumor progression. Cancer Res. 46: 2203-2207,1986.
16. Schipper, J. H. Frixen, U. H. Behrens, J. Unger, A. Jahnke. K. and Birchmeier, W. E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis. Cancer Res. 51: 6328-6337, 1991.
17. Hashimoto, M. Niwa, O. Nitta, Y. Takeichi, M. and Yokoro, K. A. F. Unstable expression of E-cadherin adhesion molecules in metastatic ovarian tumor cells. Jpn. J. Cancer Res. 80: 459-463. 1989.
18. Marcel, M. M. Behrens. J. Birchmeier. W. De Bruyne. G. K. Vleminckx, K. Hoogewijs, A. Fiers. W. and Van Roy, F. Down-regulation of E-cadherin expression in Madin Darby canine kidney (MDCK) cells inside tumors of nude mice, Int. J. Cancer. 47: 922-928. 1991.
19. Ozawa, M. Ringwald, M. and Kemler. R. Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule. Proc. Natl. Acad. Sci. USA. 87: 4246-4250. 1990.
20. Herrenknecht, K. Ozawa, M. Eckerskorn. C., Lottspeich, E. Lenter. M. and Kemler. R. The uvomorulin-anchorage protein Ά catenin is a vinculin homologue. Proc. Natl. Acad. Sci. USA. 88: 9156-9160. 1991.
21. Nagaruchi, A. and Takeichi, M. Cell binding function of E-cadherin is regulated by the cytoplasmic domain. EMBO J. 7: 3679-3684, 1988.
22. Shimoyama, Y. Nagafuchi, A. Fujita, S. Gotoh, M. Takeichi, M. Tsukita, S. and Hirohashi, S. Cadherin dysfunction in a human cancer cell line: possible involvement of loss of Ά;-catenin expression in reduced cell-cell adhesiveness. Cancer Res. 52: 5770-5774, 1992.
23. Shimoyama, Y. and Hirohashi, S. Expresssion of E and P cadherin in gastric carcinomas. Cancer Res. 57; 2185-2192, 1991.
24. Inoue, M. Ogawa, H. Miyata, M. Shiozaki, H. and Tanizawa, O. Expression of E-cadherin in normal, benign, and malignant tissues of female genital organs. Am. J. Clin. Pathol. 98: 76-80, 1992.
25. Giroldi, L. A. and Schalken, J. Decreased expression of the intercellular adhesion molecule E-cadherin in prostate cancer biological significance and clinical implication. Cancer Metastasis Rev. 72; 29-37, 1992.