-
1
-
-
0026642637
-
Physiological and Molecular Mechanisms of Lymphocyte Homing
-
of outstanding interest, This review provides an overview of the mechanisms that control the homing of lymphocyte populations in vivo, particularly the adhesive interactions involved in lymphocyte-endothetial cell recognition. Also discussed is the selective extravasation of lymphocyte populations into secondary and tertiary lymphoid tissues.
-
(1992)
Annu Rev/mmunol
, vol.10
, pp. 561-581
-
-
Picker1
Butcher2
-
2
-
-
0026815051
-
Migration Pathways and Immunologic Memory among T Lymphocytes
-
of outstanding interest, This review brings together the molecular mechanisms and physiology of lymphocyte homing, and discusses these in relation to T-cell memory.
-
(1992)
Semin Immunol
, vol.4
, pp. 51-58
-
-
Mackay1
-
3
-
-
0026342111
-
Leukocyte-Endothelial Cell Recognition: Three (or More) Steps to Specificity and Diversity
-
of outstanding interest, A conceptual development for leukocyte homing. Here, E Butcher proposes the multi-step model of leukocyte binding to endothelium. An important implication from this model is that the whole process relies on combinatorial steps, such that the type of leukocyte that binds to endothelium in a particular tissue depends not only on the initial specificity of the selectin interaction, but also on the action of the various chemokines or other stimulating agents, and the types of integrins and their receptors that are expressed. Thus, small differences in the expression of certain adhesion molecules by two cell types (for instance naive and memory T cells) may be amplified through three different steps, resulting in markedly different efficiencies in endothelial binding and transmigration.
-
(1991)
Cell
, vol.67
, pp. 1033-1036
-
-
Butcher1
-
4
-
-
0025854524
-
Leukocytes Roll on a Selectin at Physiologic Flow Rates: Distinction from and Prerequisite for Adhesion Through Integrins
-
of outstanding interest, Similar to [3••], this paper proposes a multi-step model for leukocyte binding to endothelium. The authors used artificial lipid bilayers containing P-selectin. Addition of a chemoattractant to activate LFA-1 and Mac-1 on neutrophils resulted in the arrest of neutrophil rolling on bilayers, and firm adhesion.
-
(1991)
Cell
, vol.65
, pp. 859-873
-
-
Lawrence1
Springer2
-
5
-
-
0026513705
-
Lymphocyte Interactions with Endothelial Cells
-
of outstanding interest, A comprehensive review of lymphocyte interactions with endothelial cells, encompassing molecular and physiological aspects.
-
(1992)
Immunol Today
, vol.13
, pp. 106-112
-
-
Shimizu1
Newman2
Tanaka3
Shaw4
-
6
-
-
0026100981
-
ELAM-1 is an Adhesion Molecule for Skin-homing T Cells
-
of outstanding interest, COS cells transfected with E-selectin bound to a skin-associated subset of circulating memory T cells defined by the expression of CLA. Immunohistology revealed that E-selectin expression occurred at cutaneous sites in preference to non-cutaneous sites. The authors concluded that E-selectin may function as a skin vascular addressin, a tissue-selective endothelial cell adhesion molecule for skin-homing memory T lymphocytes.
-
(1991)
Nature
, vol.349
, pp. 779-796
-
-
Picker1
Kishimoto2
Smith3
Warnock4
Butcher5
-
9
-
-
0027302705
-
Immunological Memory
-
+), suggesting that [[Truncated]]
-
(1993)
Adv Immunol
, vol.53
, pp. 217-265
-
-
Mackay1
-
10
-
-
0026810631
-
The Dynamics of Immunological Memory
-
of special interest, D Gray is one of the main proponents of the heretical model for immunological memory, which holds that antigen persistence is critically important for the longeivity of memory. He supports his views with a review of the population kinetics of peripheral lymphocytes, and the evidence implicating a role for antigen in memory cell survival.
-
(1992)
Semin Immunol
, vol.4
, pp. 29-34
-
-
Gray1
-
11
-
-
0026445567
-
Lifespan of Human Lymphocyte Subsets Defined by CD45 Isoforms
-
+ phenotype. Both of these notions have been around for some time, however this study was an elegant demonstration of their validity.
-
(1992)
Nature
, vol.360
, pp. 264-265
-
-
Michie1
McLean2
Alcock3
Beverley4
-
12
-
-
0026816125
-
Function of CD4 T Cell Subsets in Vivo. Expression of CD45R Isoforms
-
of special interest, E Bell argues doggedly that CD45 isoforms on T cells in the rat are markers of activation state rather than naive and memory T cells, as certain isoforms are interchangeable. He is probably right.
-
(1992)
Semin Immunol
, vol.4
, pp. 43-50
-
-
Bell1
-
15
-
-
0025821091
-
The Human Peripheral Lymph Node Vascular Addressin is a Ligand for LECAM-1, the Peripheral Lymph Node Homing Receptor
-
of special interest, L-selectin mediates lymphocyte binding to the peripheral node vascular addressin (MECA-79), an interaction that involves the lectin of L-selectin and carbohydrate determinants on the addressin.
-
(1991)
J Cell Biol
, vol.114
, pp. 343-349
-
-
Berg1
Robinson2
Warnock3
Butcher4
-
16
-
-
0026603238
-
Lymphocyte Adhesion to High Endothelium is Mediated by Two β1 Integrin Receptors for Fibronectin, α4β1 and α5β1
-
of special interest, Implicates the integrins α4β1 and α5β1 in adhesion to HEVs in lymph nodes. α4β1 and α5β1 are expressed by lymphocytes but not neutrophils, and so L-selectin mediated rolling followed by β1 integrin adhesion may determine the exclusive entry of lymphocytes into lymph nodes (under normal circumstances). It is likely that α4β1 and α5β1 recognize fibronectin on HEVs, rather than VCAM-1, which is normally absent from lymph node and Peyer's patch HEVs.
-
(1992)
J Cell Sci
, vol.101
, pp. 885-894
-
-
Szekanecz1
Humphries2
Ager3
-
17
-
-
0015722745
-
Maturation of B Lymphocytes in the Rat. I. Migration Pattern, Tissue Distribution, and Turnover Rate of Unprimed and Primed B Lymphocytes Involved in the Adoptive Antidinitrophenyl Response
-
(1973)
J Exp Med
, vol.138
, pp. 1331-1344
-
-
Strober1
Dilley2
-
18
-
-
0026705574
-
Homing of Blood, Splenic, and Lung Emigrant Lymphoblasts: Comparison with the Behaviour of Lymphocytes from these Sources
-
of special interest, The homing patterns of various blast cells and lymphocytes in vivo was determined using radioactive labels. Lymphoblasts did not predominantly home to the mucosa, but distributed throughout several non-lymphoid tissues, and showed differences in migration preferences depending on their source.
-
(1992)
Int Immunol
, vol.4
, pp. 1011-1019
-
-
Binns1
Licence2
Pabst3
-
19
-
-
0026446109
-
Selective Endothelial Binding of Interleukin-2-dependent Human T-cell Lines Derived from Different Tissues
-
of special interest, Using T-cell lines, this study showed that the tissue origin of T cells has a bearing on their selectivity for endothelial cell recognition. These findings add weight to the notion that the T cells that display tissue-selective homing are recently or previously activated. In addition, firm evidence for a synovial specificity by T-cell fines is presented.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 11436-11440
-
-
Salmi1
Granfors2
Leirisaw-Repo3
Hamalainen4
MacDermott5
Leino6
Havla7
Jalkanen8
-
20
-
-
0026593810
-
Tissue-specific Migration Pathways by Phenotypically Distinct Subpopulations of Memory T Cells
-
of special interest, Lymphocytes migrating through the gut and the skin of sheep were collected by cannulating the lymphatic ducts draining these tissues. Both naive and memory T cells migrated through the gut. However, when T cells from the gut were labeled with FIT, and assessed for their migration back to the gut, it was the memory population that showed a tropism for the gut. Gut memory T cells expressed very low levels of the α6 and β1 integrins, in contrast with skin memory T cells that expressed high levels. Unfortunately no reagents were available to examine β7 expression.
-
(1992)
Eur J Immunol
, vol.22
, pp. 887-895
-
-
Mackay1
Marston2
Dudler3
Spertini4
Tedder5
Hein6
-
21
-
-
0027207679
-
MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1.
-
+ memory T-cell migration through these lymphoid tissues.
-
(1993)
Nature
-
-
Briskin1
McEvoy2
Butcher3
-
26
-
-
0026743048
-
Altered Patterns of T Cell Migration Through Lymph Nodes and Skin Following Antigen Challenge
-
+ memory-type T cells. The HEVs of challenged lymph nodes expressed VCAMA, demonstrating similarities between challenge lymph nodes and inflamed tissues. Within chronically inflamed skin, the MECA-79 determinant appeared on vascular endothelium after about 3 days, and a small proportion of T cells draining from chronically inflamed skin were of naive-type. The expression of MECA-79 may be a prelude to the development of more organized lymphoid tissue in chronically inflamed tissue.
-
(1992)
Eur J Immunol
, vol.22
, pp. 2205-2210
-
-
Mackay1
Marston2
Dudler3
-
27
-
-
0026090496
-
Activation-independent Binding of Human Memory T Cells to Adhesion Molecule ELAM-1
-
+) preferentially bind to the endothelial adhesion molecule E-selectin (formerly termed ELAM-1). This binding was not dependent on activiating stimuli, such as those that induce integrin binding. This study provided one of the clues as to why memory T cells home differentially compared with naive-type T cells.
-
(1991)
Nature
, vol.349
, pp. 799-802
-
-
Shimizu1
Shaw2
Graber3
Gopal4
Horgan5
Van6
Newman7
-
28
-
-
0025038599
-
Selective Attraction of Monocytes and T Lymphocytes of the Memory Phenotype by Cytokine RANTES
-
(1990)
Nature
, vol.347
, pp. 669-07129
-
-
Schall1
Bacon2
Toy3
Goeddel4
-
29
-
-
0027509103
-
T-cell Adhesion Induced by Proteoglycan-immobilized Cytokine MIP-1β
-
+ cell adhesion to VCAM-1. This paper describes a mechanism whereby MIP-1β is immobilized on endothelium through binding to proteoglycans, such as CD44. This would prevent the cytokine from being washed away from an inflammatory site. The question is, how many more such cytokines exist that may regulate the differential recruitment of lymphocyte subsets to various tissues?
-
(1993)
Nature
, vol.361
, pp. 79-82
-
-
Tanaka1
Adams2
Hubscher3
Hirano4
Siebenlist5
Shaw6
-
30
-
-
0026541710
-
Evidence for Recent as Well as Long Term Activation of T Cells Migrating Through Endothelial Cell Monolayers in Vitro
-
of special interest, This paper examined the activation state of human peripheral blood T cells that adhered to and migrated through endothelial cell monolayers. The small component of activated T cells in human blood were the cell type that preferentially bound and migrated through the endothelial monolayer.
-
(1992)
J Immunol
, vol.148
, pp. 1367-1374
-
-
Masuyama1
Berman2
Cruikshank3
Morimoto4
Center5
|