Patent update: Neurokinin receptor antagonists

Expert Opinion on Therapeutic Patents

Volumn 3, Issue 8, 1993, Pages 1157-1172

  Mcelroy, Andrew B ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

17ALPHA ETHYNYL 17BETA HYDROXY 5ALPHA ANDROSTANO[3,2 B]PYRIMIDO[1,2 A]BENZIMIDAZOLE; 2 [1 IMINO 2 (2 METHOXYPHENYL)ETHYL] 7,7 DIPHENYLPERHYDROISOINDOL 4 ONE; 2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; 2 ETHYL 5,7 DIMETHYL 3 [4 [2 (2H TETRAZOL 5 YL)PHENYL]BENZYL]IMIDAZO[4,5 B]PYRIDINE; ACETYLLEUCYLASPARTYLGLUTAMINYLTRYPTOPHYLPHENYLALANYLGLYCINAMIDE; CYCLO(GLUTAMINYLTRYPTOPHYLPHENYLALANYLGLYCYLLEUCYLMETHIONYL); DACTINOMYCIN; DRUG ANALOG; FK 224; FR 113680; GR 71251; HEPTAPEPTIDE; HEXAPEPTIDE; L 668169; LOSARTAN POTASSIUM; NEUROKININ 1 RECEPTOR; NEUROKININ 2 RECEPTOR; NEUROKININ 3 RECEPTOR; NEUROKININ A; NEUROKININ A [4-10][5 TYROSINE 6,8,9 DEXTRO TRYPTOPHAN 10 ARGININE]; NEUROKININ B; NEUROKININ DERIVATIVE; NOLPITANTIUM; PHYSALAEMIN[9 DEXTRO PROLINE SPIRO GAMMA LACTAM 10 LEUCINE 11 TRYPTOPHAN]; RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE; SAREDUTANT; SPANTIDE; SUBSTANCE P; SUBSTANCE P ANTAGONIST; SUBSTANCE P DERIVATIVE; TACHYKININ RECEPTOR; UNCLASSIFIED DRUG;

BRONCHOSPASM; DOPAMINERGIC NERVE CELL; DRUG ANTAGONISM; DRUG STRUCTURE; EXTRAVASATION; GUINEA PIG; HAMSTER; HUMAN; INTRAPERITONEAL DRUG ADMINISTRATION; INTRATHECAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NEUROCHEMISTRY; NOCICEPTION; NONHUMAN; ORAL DRUG ADMINISTRATION; RABBIT; RAT; REVIEW;

EID: 0027296875     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.3.8.1157     Document Type: Article

References (60)

1. Nonpeptide antagonists her-ald new era in tachykinin research
2. Tachykinin receptors and tachykinin receptor antagonists
3. Tachykinin receptor an-tagonists and potential ciinicai appfications at the peripheral level
4. Neuro-kinin agonists and antagonists
5. Pharmacological properties of a potent and selective nonpeptide substance P antagonist
6. Inhibition of neurogenic plasma extravasation in guinea-pig airways by CP-96, 345, a non-peptide NKi receptor antagonist
7. Highly potent and selective heptapep-tide antagonists of the neurokinin NK-2 re-ceptor
8. Turning behaviour induced in mice by a neurokinin A receptor agonist: stereoselective blockade by SR 48968, a non-peptide receptor antag-onist
9. Chemical design of antagonists of sub-stance P. Acta Physiol. Scand
10. Design and synthesis of effective antagonists of substance PActa Chem. Scand. Ser B
11. Syn-thesis and structure activity studies on no-vel SP-antagonists, an exercise in medicinal chemistry
12. Biological evaluation of substance P antagonists
13. An analogue of substance P with broad receptor antagonist activity
14. WEISENFELD-HALLZIN, LEANDERS : Spantide I1 an effective tachykinin antagonist having high potency and negligible neurotoxicity
15. KISARA K: Selective antago-nistic effects of substance P (6-11) analogues on the spinally induced, neurokinin 1 recep-tor mediated behavioural response
16. A selective and extremely potent antagonist of the neurokinin-1 receptor Brain Res
17. Studies on neurokinin antagonists
18. F u ~ nT Effects of FR 113680 and FK 224, novel tachykinin receptor antagonists, on cigarette smoke-induced rat tracheal plasma extravasation
19. Neurokinin receptor antago-nists old and new
20. Pharmacological characteri-sation of new neurokinin (substance P) antagonists
21. Antagonists that demon-strate species differences in neurokinin-1 re-ceptors
22. Cyclic peptides as selective tachykinin an-tagonists
23. Potent and highly selective neurokinin antagonists
24. Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions
25. Effect of the spirolactam NK-1 receptor antag-onist, GR82334, on neurokinin- and electri-cal stimulation-induced oedema in the rat. Br. J. Pharmacol
26. WS9326A, A novel tachykinin antagonist isolated from Strep-tomyces violaceusnigers
27. FUJI' T: FK 224, A novel cyclopeptide substance P an-tagonist with NK-1 and NK-2 receptor se-lectivity
28. FK-224; Neurokinin Antagonist
29. Low molecular weight neurokinin NK2 antagonists
30. CA, WEISEN-FELD-HALLIN Z: NK-1, but not NK-2, tachy-kinin receptors mediate plasma extravasa-fion induced by antidromic C-fiber stimula-tion in rat hindpaw: demonstrated with the NK-1 antagonist CP-96,345 and the NK-2 antagonist Men 10207
31. Role of D-tryptophan for affinity of MEN 10207 tachykinin antagonist at NK-2 receptors
32. Structure-activity study of the C-terminal of MEN10207 tachykinin antagonist
33. Pharmacological and biochemical evidence for multiple types of tachykinin NK2 receptors
34. Structure-activity relationship of R396, an NK2 tachy-kinin antagonist selective for the NK2B re-ceptor subtype
35. Devel-opment of NK-2 selective antagonists
36. JM: Dactino-mycin is a competitive neurokinin-2 receptor antagonist
37. LE T-B, BUCK SH: A new class of high affinity figands for the neurokinin A NK2 receptor: yr(CH2NR) reduced peptide bond analogues of neuro-kinin A410
38. Recent advances in neuro-kinin receptor antagonists
39. A potent non-peptide antagonist of the substance P NKi receptor
40. Activity and distribution of binding sites in the brain of a nonpeptide substance P (MCI) receptor antagonist
41. Effect of CP-96,345, a non-peptide substance P receptor antagonist, on salivation in rats
42. Investigation into species vari-ants in tachykinin NK-1 receptors by use of the non-peptide antagonist, CP-96,345
43. Non-peptide antago-nists, CP-96,345 and RP 67580, distinguish species variants in tachykinin NK-1 recep-tors
44. Molec-ular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580
45. SR 140333, A novel characterisation on the U373MG cell line
46. Synthesis and substance P receptor activity of androstano[3,2-b]pyrimido[ 112-a]benzimidazoles
47. Imidazo[4,5-b]quinoxaline cyanines as neurokinin antagonists
48. A potent and selective non-peptide antago-nist of the neurokinin A (NK2) receptor. Life Sci
49. Effects on the isolated human bronchus of SR 48968, a potent and selective nonpeptide antagonist of the neurokinin A (NK2) receptors
50. Neurokinin A (NK2) receptor re-visited with SR 48968, a potent non-peptide antagonist
51. GUILLEMEI lb G,REGOLI D: Non-peptide angiotensin antago-nists bind to NK-3 neurokinin receptors of rat and guinea-pig brain